Klk6
Gene Detail

Symbol Name ID

Klk6 kallikrein related-peptidase 6 MGI:1343166

Synonyms

Bssp, Klk29, neurosin, protease M, Prss18, Prss9

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.28 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:43824499-43832027 bp, + strand From VEGA annotation of GRCm38   7529 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Klk6

Human homologs

Human Homolog		KLK6, kallikrein-related peptidase 6
NCBI Gene ID		5653
neXtProt AC		NX_Q92876
Human Synonyms		Bssp, hK6, Klk7, PRSS18, PRSS9, SP59
Human Chr (Location)		19q13.3; chr19:51461887-51472929 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(1) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	positive regulation of G-protein coupled receptor protein signaling pathway, proteolysis, ...
Component	cytoplasm, extracellular region
Function	hydrolase activity, peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (3)
Theiler Stages: 28

Assay Type	Results
RNA in situ	4
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(2) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022524 (Evidence)
Ensembl Gene Model	ENSMUSG00000050063 (Evidence)
Entrez Gene	19144 (Evidence)
UniGene	3944
DFCI	TC1585094
DoTS	DT.101359856, DT.484978
NIA Mouse Gene Index	U068192
Consensus CDS Project	CCDS21184.2
International Mouse Knockout Project Status	Klk6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022524	VEGA Gene Model | MGI Sequence Detail	7529	C57BL/6J
transcript	OTTMUST00000053947	VEGA | MGI Sequence Detail	1391	Not Applicable
polypeptide	OTTMUSP00000025687	VEGA | MGI Sequence Detail	253	Not Applicable

All sequences(43) RefSeq(8) UniProt(3)

Polymorphisms

SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000009416	kallikrein-6

References

(Earliest) J:54930 Meier N, et al., A novel serine protease overexpressed in the hair follicles of nude mice. Biochem Biophys Res Commun. 1999 May 10;258(2):374-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)

Other accession IDs

MGI:1347349, MGI:2142052