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Klk6 Gene Detail
Summary
  • Symbol
    Klk6
  • Name
    kallikrein related-peptidase 6
  • Synonyms
    Bssp, Klk29, neurosin, protease M, Prss18, Prss9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343166
    NCBI Gene: 19144
  • Gene Overview
    MyGene.info: KLK6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43824544-43832027 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.28 cM, cytoband B4-B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    197 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343166
protein coding gene Chr7:43824499-43832030 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032145
protein coding gene Chr7:43874312-43883973 (+)
A/J MGP_AJ_G0032130
protein coding gene Chr7:42954405-42963274 (+)
AKR/J MGP_AKRJ_G0032060
protein coding gene Chr7:44340426-44349613 (+)
BALB/cJ MGP_BALBcJ_G0032135
protein coding gene Chr7:43071672-43079421 (+)
C3H/HeJ MGP_C3HHeJ_G0031851
protein coding gene Chr7:44848622-44857240 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032619
protein coding gene Chr7:46081112-46091034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029642
protein coding gene Chr7:45088560-45095746 (+)
CAST/EiJ MGP_CASTEiJ_G0031181
protein coding gene Chr7:36040136-36047608 (+)
CBA/J MGP_CBAJ_G0031820
protein coding gene Chr7:47545478-47552999 (+)
DBA/2J MGP_DBA2J_G0031969
protein coding gene Chr7:42761599-42768918 (+)
FVB/NJ MGP_FVBNJ_G0031930
protein coding gene Chr7:42472865-42480246 (+)
LP/J MGP_LPJ_G0032048
protein coding gene Chr7:44596022-44603537 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031966
protein coding gene Chr7:46465187-46474777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032639
protein coding gene Chr7:43468819-43477206 (+)
PWK/PhJ MGP_PWKPhJ_G0030902
protein coding gene Chr7:36212784-36220264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030741
protein coding gene Chr7:31497165-31507295 (+)
WSB/EiJ MGP_WSBEiJ_G0031295
protein coding gene Chr7:44017111-44024636 (+)



Homology
more
  • Human Ortholog
    KLK6, kallikrein related peptidase 6
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLK6, kallikrein related peptidase 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Bssp, hK6, Klk7, PRSS18, PRSS9, SP59
  • Links
    NCBI Gene ID: 5653
    neXtProt AC: NX_Q92876
    UniProt: Q92876

  • Chr Location
    19q13.41; chr19:50958631-50969673 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased mature oligodendrocytes in the developing spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19144 NCBI Gene Model | MGI Sequence Detail 7484 C57BL/6J ±  kb
transcript NM_011177 RefSeq | MGI Sequence Detail 1358 C57BL/6  
polypeptide NP_001158168 RefSeq | MGI Sequence Detail 253 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
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  • All nucleic 15
    Genomic 2
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1347349, MGI:2142052
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:54930 Meier N, et al., A novel serine protease overexpressed in the hair follicles of nude mice. Biochem Biophys Res Commun. 1999 May 10;258(2):374-8
  • Latest
    J:254362 Bando Y, et al., Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis. Glia. 2018 Feb;66(2):359-378

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory