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Klk6
Gene Detail
 Symbol
Name
ID
Klk6
kallikrein related-peptidase 6
MGI:1343166
Synonyms Bssp, Klk29, neurosin, protease M, Prss18, Prss9
Feature Type protein coding gene
Genetic Map
Chromosome 7
28.28 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:43824499-43832027 bp, + strand
From VEGA annotation of GRCm38

  7529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Klk6

Human
homologs
Human Homolog KLK6, kallikrein-related peptidase 6
NCBI Gene ID 5653
neXtProt AC  NX_Q92876
Human Synonyms  Bssp, hK6, Klk7, PRSS18, PRSS9, SP59
Human Chr (Location)  19q13.3; chr19:50958631-50969673 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased mature oligodendrocytes in the developing spinal cord.
 
Interactions
Klk6 interacts with 59 markers (Mir185, Mir207, Mir210, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process neuron death, positive regulation of G-protein coupled receptor protein signaling pathway, ...
Component cytoplasm, extracellular region, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (3)
Theiler Stages: 28
Assay TypeResults
RNA in situ 4
RT-PCR 2
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022524 (Evidence)
Ensembl Gene ModelENSMUSG00000050063 (Evidence)
Entrez Gene19144 (Evidence)
UniGene3944
DFCITC1585094
DoTSDT.484978, DT.101359856
NIA Mouse Gene IndexU068192
Consensus CDS ProjectCCDS21184.2
International Mouse Knockout Project StatusKlk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022524 VEGA Gene Model | MGI Sequence Detail 7529 C57BL/6J ±  kb
transcript OTTMUST00000053947 VEGA | MGI Sequence Detail 1391 Not Applicable 
polypeptide OTTMUSP00000025687 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009416 kallikrein-6
References (Earliest) J:54930 Meier N, et al., A novel serine protease overexpressed in the hair follicles of nude mice. Biochem Biophys Res Commun. 1999 May 10;258(2):374-8
(Latest) J:202184 Yoon H, et al., Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. J Neurochem. 2013 Oct;127(2):283-98
All references(44)
Other
accession IDs
MGI:1347349, MGI:2142052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory