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Klk6
Gene Detail
Symbol

Name
ID
Klk6
kallikrein related-peptidase 6
MGI:1343166
Synonyms
Bssp, Klk29, neurosin, protease M, Prss18, Prss9
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.28 cM, cytoband B4-B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:43824499-43832027 bp, + strand
From VEGA annotation of GRCm38

  7529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68279  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: KLK6
Protein SuperFamily: trypsin
Gene Tree: Klk6

Human
homologs
KLK6, kallikrein-related peptidase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5653
neXtProt AC: NX_Q92876

Human Synonyms: Bssp, hK6, Klk7, PRSS18, PRSS9, SP59

Human Chr (Location): 19q13.3; chr19:50958631-50969673 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased mature oligodendrocytes in the developing spinal cord.
 
Interactions
Klk6 interacts with 59 markers (Mir185, Mir207, Mir210, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
RT-PCR 2
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(10) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022524 (Evidence)
Ensembl Gene Model ENSMUSG00000050063 (Evidence)
Entrez Gene 19144 (Evidence)
UniGene 3944
DFCI TC1585094
DoTS DT.101359856, DT.484978
NIA Mouse Gene Index U068192
Consensus CDS Project CCDS21184.2
International Mouse Phenotyping Consortium Status Klk6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022524 VEGA Gene Model | MGI Sequence Detail 7529 C57BL/6J ±  kb
transcript OTTMUST00000053949 VEGA | MGI Sequence Detail 1117 Not Applicable 
polypeptide OTTMUSP00000025689 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(206 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000009416 kallikrein-6
References
(Earliest) J:54930 Meier N, et al., A novel serine protease overexpressed in the hair follicles of nude mice. Biochem Biophys Res Commun. 1999 May 10;258(2):374-8
(Latest) J:202184 Yoon H, et al., Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. J Neurochem. 2013 Oct;127(2):283-98
All references(42)
Other
accession IDs
MGI:1347349, MGI:2142052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory