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Snf8
Gene Detail
Symbol

Name
ID
Snf8
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
MGI:1343161
Synonyms
D11Moh34, MGC:7335
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:96034885-96047430 bp, + strand
From VEGA annotation of GRCm38

  12546 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5239  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ESCRT-2 complex, Vps22 subunit
Gene Tree: Snf8

Human
homologs
Human Homolog SNF8, SNF8, ESCRT-II complex subunit
NCBI Gene ID 11267
neXtProt AC  NX_Q96H20
Human Synonyms  Dot3, EAP30, VPS22
Human Chr (Location)  17q21.32; chr17:48930096-48944792 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(11) Targeted(7)
Genomic Mutations involving Snf8 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Snf8 interacts with 24 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process positive regulation of exosomal secretion, protein transport, ...
Component cytoplasm, endosome, ...
Function protein homodimerization activity, transcription factor binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (23)    Tissues (22)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
cDNA source data(91)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) Genomic(12) cDNA(91)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001957 (Evidence)
Ensembl Gene ModelENSMUSG00000006058 (Evidence)
Entrez Gene27681 (Evidence)
UniGene372235
DFCITC1607442, TC1577622, TC1655050, TC1683870
DoTSDT.102541273, DT.55100221, DT.101316956, DT.94378645, DT.60104688
NIA Mouse Gene IndexU013236, U167110
Consensus CDS ProjectCCDS25288.1
International Mouse Knockout Project StatusSnf8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001957 VEGA Gene Model | MGI Sequence Detail 12546 C57BL/6J ±  kb
transcript OTTMUST00000003921 VEGA | MGI Sequence Detail 1004 Not Applicable 
polypeptide OTTMUSP00000001898 VEGA | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)    SNPs within 2kb including multiple locations(132)
Protein-related
information
ResourceIDDescription
InterPro IPR007286 EAP30
InterPro IPR016689 ESCRT-2 complex, Snf8
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015327 vacuolar-sorting protein SNF8
References
(Earliest) J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory