About   Help   FAQ
Dctn6 Gene Detail
Summary
  • Symbol
    Dctn6
  • Name
    dynactin 6
  • Synonyms
    p27, WS-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343154
    NCBI Gene: 22428
Location & Maps
more
  • Sequence Map
    Chr8:34090420-34108796 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18377 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 20.90 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DCTN6, dynactin subunit 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCTN6, dynactin subunit 6
    Orthology source: HomoloGene
  • Synonyms
    p27, WS3, WS-3
  • Links
    NCBI Gene ID: 10671
    neXtProt AC: NX_O00399

  • Chr Location
    8p12; chr8:30156297-30183639 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    15
  • Endonuclease-mediated
    1
  • Gene trapped
    12
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031286 VEGA Gene Model | MGI Sequence Detail 18377 C57BL/6J ±  kb
transcript OTTMUST00000077521 VEGA | MGI Sequence Detail 962 Not Applicable  
polypeptide OTTMUSP00000041019 VEGA | MGI Sequence Detail 195 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    242 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 90
    cDNA 90

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142720
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:54917 Murdock DG, et al., Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator. J Biol Chem. 1999 May 14;274(20):14429-33
  • Latest
    J:195306 Yeh TY, et al., Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. EMBO J. 2013 Apr 3;32(7):1023-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory