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Ikzf4 Gene Detail
Summary
  • Symbol
    Ikzf4
  • Name
    IKAROS family zinc finger 4
  • Synonyms
    A630026H08Rik, Eos, Zfpn1a4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343139
    NCBI Gene: 22781
  • Gene Overview
    MyGene.info: IKZF4
Location & Maps
more
  • Sequence Map
    Chr10:128630843-128645991 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15149 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.11 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IKZF4, IKAROS family zinc finger 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IKZF4, IKAROS family zinc finger 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EOS, ZNFN1A4
  • Links
    NCBI Gene ID: 64375
    neXtProt AC: NX_Q9H2S9

  • Chr Location
    12q13; chr12:56007647-56038435 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    7
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025110 VEGA Gene Model | MGI Sequence Detail 15149 C57BL/6J ±  kb
transcript OTTMUST00000074372 VEGA | MGI Sequence Detail 2213 Not Applicable  
polypeptide OTTMUSP00000038692 VEGA | MGI Sequence Detail 686 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    316 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002984 zinc finger protein Eos
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2441811
References
more
  • Summaries
    All 40
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:53896 Honma Y, et al., Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system. FEBS Lett. 1999 Mar 19;447(1):76-80
  • Latest
    J:204570 Bottardi S, et al., Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells. Mol Cell Biol. 2013 Aug;33(16):3064-76

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory