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Robo3
Gene Detail
Symbol

Name
ID
Robo3
roundabout homolog 3 (Drosophila)
MGI:1343102
Synonyms
Rbig1, Rig1, Rig-1, Robo3a, Robo3b
Feature Type
protein coding gene
Genetic Map
Chromosome 9
20.76 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:37415669-37433163 bp, - strand
From VEGA annotation of GRCm38

  17495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ROBO3
Gene Tree: Robo3

Human
homologs
ROBO3, roundabout guidance receptor 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64221
neXtProt AC: NX_Q96MS0

Human Synonyms: HGPPS, HGPS, RBIG1, RIG1

Human Chr (Location): 11q24.2; chr11:124865006-124881474 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ROBO3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants display perinatal lethality, abnormal commissural axon growth, and fragile floor plates.
 
Human Diseases Modeled in Mice Using Robo3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Robo3 interacts with 52 markers (Mir23a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process axon guidance, axon midline choice point recognition, ...
Component axon, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (278)    Tissues (126)    Images (97)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 223
Northern blot 8
Western blot 29
RT-PCR 14
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase robo3 ; ZFIN robo3    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016764 (Evidence)
Ensembl Gene Model ENSMUSG00000032128 (Evidence)
Entrez Gene 19649 (Evidence)
UniGene 212826
DFCI TC1589197, TC1602303
DoTS DT.97391931, DT.101724807
NIA Mouse Gene Index U030688
Consensus CDS Project CCDS52770.1
International Mouse Phenotyping Consortium Status Robo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016764 VEGA Gene Model | MGI Sequence Detail 17495 C57BL/6J ±  kb
transcript OTTMUST00000040687 VEGA | MGI Sequence Detail 4714 Not Applicable 
polypeptide OTTMUSP00000018189 VEGA | MGI Sequence Detail 1402 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000014153 roundabout homolog 3
References
(Earliest) J:53337 Yuan SS, et al., Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(83)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory