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Robo3
Gene Detail
 Symbol
Name
ID
Robo3
roundabout homolog 3 (Drosophila)
MGI:1343102
Synonyms Rbig1, Rig1, Rig-1, Robo3a, Robo3b
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.76 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:37415669-37433163 bp, - strand
From VEGA annotation of GRCm38

  17495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Robo3

Human
homologs
Human Homolog ROBO3, roundabout, axon guidance receptor, homolog 3 (Drosophila)
NCBI Gene ID 64221
neXtProt AC  NX_Q96MS0
Human Synonyms  HGPPS, HGPS, RBIG1, RIG1
Human Chr (Location)  11q24.2; chr11:124865409-124881474 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ROBO3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display perinatal lethality, abnormal commissural axon growth, and fragile floor plates.
 
Interactions
Robo3 interacts with 52 markers (Mir23a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process axon guidance, axon midline choice point recognition, ...
Component axon, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (276)    Tissues (124)    Images (97)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 221
Northern blot 8
Western blot 29
RT-PCR 14
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016764 (Evidence)
Ensembl Gene ModelENSMUSG00000032128 (Evidence)
Entrez Gene19649 (Evidence)
UniGene212826
DFCITC1589197, TC1602303
DoTSDT.101724807, DT.97391931
NIA Mouse Gene IndexU030688
Consensus CDS ProjectCCDS52770.1
International Mouse Knockout Project StatusRobo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016764 VEGA Gene Model | MGI Sequence Detail 17495 C57BL/6J ±  kb
transcript OTTMUST00000040687 VEGA | MGI Sequence Detail 4714 Not Applicable 
polypeptide OTTMUSP00000018189 VEGA | MGI Sequence Detail 1402 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(11) UniProt(3)
Polymorphisms SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000014153 roundabout homolog 3
References (Earliest) J:53337 Yuan SS, et al., Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(73)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory