Robo3
Gene Detail

Symbol Name ID

Robo3 roundabout homolog 3 (Drosophila) MGI:1343102

Synonyms

Rbig1, Rig1, Rig-1, Robo3a, Robo3b

Feature Type

protein coding gene

Genetic Map

Chromosome 9

20.76 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:37415669-37433163 bp, - strand From VEGA annotation of GRCm38   17495 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Robo3

Human homologs

Human Homolog		ROBO3, roundabout, axon guidance receptor, homolog 3 (Drosophila)
NCBI Gene ID		64221
neXtProt AC		NX_Q96MS0
Human Synonyms		HGPPS, HGPS, RBIG1, RIG1
Human Chr (Location)		11q24.2; chr11:124735305-124751370 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ROBO3

Alleles and phenotypes

All alleles(3) : Targeted(2) Spontaneous(1)
 

Homozygous mutants display perinatal lethality, abnormal commissural axon growth, and fragile floor plates.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	axon guidance, axon midline choice point recognition, ...
Component	axon, integral to membrane, ...
Function	protein binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (44 records)
Data Summary: Results (264)    Tissues (115)    Images (91)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	214
Northern blot	8
Western blot	28
RT-PCR	14

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016764 (Evidence)
Ensembl Gene Model	ENSMUSG00000032128 (Evidence)
Entrez Gene	19649 (Evidence)
UniGene	212826
DFCI	TC1589197, TC1602303
DoTS	DT.101724807, DT.97391931
NIA Mouse Gene Index	U030688
Consensus CDS Project	CCDS52770.1
International Mouse Knockout Project Status	Robo3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016764	VEGA Gene Model | MGI Sequence Detail	17495	C57BL/6J
transcript	OTTMUST00000040687	VEGA | MGI Sequence Detail	4714	Not Applicable
polypeptide	OTTMUSP00000018189	VEGA | MGI Sequence Detail	1402	Not Applicable

All sequences(32) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000014153	roundabout 3

References

(Earliest) J:53337 Yuan SS, et al., Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. Dev Biol. 1999 Mar 1;207(1):62-75
(Latest) J:191773 Mirza R, et al., Cooperative slit and netrin signaling in contralateralization of the mouse trigeminothalamic pathway. J Comp Neurol. 2013 Feb 1;521(2):312-25
All references(68)