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Kat2a Gene Detail
Summary
  • Symbol
    Kat2a
  • Name
    K(lysine) acetyltransferase 2A
  • Synonyms
    1110051E14Rik, Gcn5, Gcn5l2, PCAF-B/GCN5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343101
    NCBI Gene: 14534
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100595572-100603291 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    209 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343101
 protein coding gene Chr11:100595572-100603293 (-)
129S1/SvImJ ENSMUSG00200049028
 protein coding gene Chr11:97866044-97874410 (-)
A/J ENSMUSG00195051066
 protein coding gene Chr11:97559608-97567977 (-)
AKR/J ENSMUSG00220048027
 protein coding gene Chr11:97795860-97804227 (-)
BALB/cJ ENSMUSG00180043587
 protein coding gene Chr11:97927905-97936272 (-)
C3H/HeJ ENSMUSG00175039222
 protein coding gene Chr11:97839605-97847971 (-)
C57BL/6NJ ENSMUSG00215051184
 protein coding gene Chr11:97415130-97423496 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017182
 protein coding gene Chr11:96572264-96580070 (-)
CAST/EiJ ENSTCUG00005049379
 protein coding gene Chr11:97338070-97346455 (-)
CBA/J ENSMUSG00210052739
 protein coding gene Chr11:97561203-97569569 (-)
DBA/2J ENSMUSG00185042019
 protein coding gene Chr11:97889482-97897848 (-)
FVB/NJ ENSMUSG00205042026
 protein coding gene Chr11:97746082-97754448 (-)
JF1/MsJ ENSUMUG00000044026
 protein coding gene Chr11:98141424-98149586 (-)
LP/J ENSMUSG00230046171
 protein coding gene Chr11:98942181-98950547 (-)
NOD/ShiLtJ ENSMUSG00190048115
 protein coding gene Chr11:97925601-97933967 (-)
NZO/HlLtJ ENSMUSG00225051089
 protein coding gene Chr11:100978013-100986379 (-)
PWK/PhJ ENSLUMG00010049300
 protein coding gene Chr11:97690585-97698839 (-)
SPRET/EiJ ENSMSPG00010049601
 protein coding gene Chr11:98182703-98191140 (-)
WSB/EiJ ENSIUOG00005050730
 protein coding gene Chr11:97690559-97698925 (-)



Homology
more
  • Human Ortholog
    KAT2A, lysine acetyltransferase 2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAT2A, lysine acetyltransferase 2A
  • Synonyms
    GCN5, GCN5L2, hGCN5, PCAF-b
  • Links
    NCBI Gene ID: 2648
    UniProt: Q92830

  • Chr Location
    17q21.2; chr17:42113111-42121382 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 6 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    145
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    96
  • cDNA Data
    96
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020918 Ensembl Gene Model | MGI Sequence Detail 7720 C57BL/6J ±  kb
    transcript ENSMUST00000103118 Ensembl | MGI Sequence Detail 3046 Not Applicable  
    polypeptide ENSMUSP00000099407 Ensembl | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 1
      cDNA 96
      Primer pair 2
      Other 2
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924162, MGI:2144513
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 20
      Diseases 1
      Gene Ontology 31
      Phenotypes 42
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory