About   Help   FAQ
Kat2a Gene Detail
Summary
  • Symbol
    Kat2a
  • Name
    K(lysine) acetyltransferase 2A
  • Synonyms
    1110051E14Rik, Gcn5, Gcn5l2, PCAF-B/GCN5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343101
    NCBI Gene: 14534
  • Gene Overview
    MyGene.info: KAT2A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100704746-100712465 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343101
protein coding gene Chr11:100704746-100712478 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019165
protein coding gene Chr11:103470240-103477959 (-)
A/J MGP_AJ_G0019133
protein coding gene Chr11:99155401-99163121 (-)
AKR/J MGP_AKRJ_G0019102
protein coding gene Chr11:102226404-102234124 (-)
BALB/cJ MGP_BALBcJ_G0019107
protein coding gene Chr11:99642624-99650343 (-)
C3H/HeJ MGP_C3HHeJ_G0018916
protein coding gene Chr11:102399794-102407513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019556
protein coding gene Chr11:106684700-106692419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017182
protein coding gene Chr11:96572264-96580070 (-)
CAST/EiJ MGP_CASTEiJ_G0018470
protein coding gene Chr11:103376116-103383860 (-)
CBA/J MGP_CBAJ_G0018885
protein coding gene Chr11:111137889-111145608 (-)
DBA/2J MGP_DBA2J_G0018997
protein coding gene Chr11:98692177-98699896 (-)
FVB/NJ MGP_FVBNJ_G0018987
protein coding gene Chr11:98230690-98238409 (-)
LP/J MGP_LPJ_G0019066
protein coding gene Chr11:104031892-104039611 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019018
protein coding gene Chr11:110724552-110732271 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019594
protein coding gene Chr11:102552075-102559794 (-)
PWK/PhJ MGP_PWKPhJ_G0018233
protein coding gene Chr11:99729984-99737720 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018025
protein coding gene Chr11:102294472-102302220 (-)
WSB/EiJ MGP_WSBEiJ_G0018519
protein coding gene Chr11:102540313-102548032 (-)



Homology
more
  • Human Ortholog
    KAT2A, lysine acetyltransferase 2A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KAT2A, lysine acetyltransferase 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCN5, GCN5L2, hGCN5, PCAF-b
  • Links
    NCBI Gene ID: 2648
    neXtProt AC: NX_Q92830
    UniProt: Q92830

  • Chr Location
    17q21.2; chr17:42113111-42121393 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 6 alleles in 9 genetic backgrounds
    26 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020918 Ensembl Gene Model | MGI Sequence Detail 7720 C57BL/6J ±  kb
    transcript ENSMUST00000103118 Ensembl | MGI Sequence Detail 3046 Not Applicable  
    polypeptide ENSMUSP00000099407 Ensembl | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 1
      cDNA 96
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924162, MGI:2144513
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 19
      Phenotypes 27
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:255254 Wang Y, et al., The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation. Cell Rep. 2017 Jul 18;20(3):600-612

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory