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Kat2a
Gene Detail
 Symbol
Name
ID
Kat2a
K(lysine) acetyltransferase 2A
MGI:1343101
Synonyms 1110051E14Rik, Gcn5, Gcn5l2, PCAF-B/GCN5
Feature Type protein coding gene
Genetic Map
Chromosome 11
63.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:100704746-100712465 bp, - strand
From VEGA annotation of GRCm38

  7720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41343  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone acetylase PCAF
Gene Tree: Kat2a

Human
homologs
Human Homolog KAT2A, K(lysine) acetyltransferase 2A
NCBI Gene ID 2648
neXtProt AC  NX_Q92830
Human Synonyms  GCN5, GCN5L2, hGCN5, PCAF-b
Human Chr (Location)  17q21; chr17:42113111-42121393 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(5) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Kat2a interacts with 91 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process cell proliferation, histone acetylation, ...
Component Ada2/Gcn5/Ada3 transcription activator complex, extracellular space, ...
Function chromatin binding, H3 histone acetyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (178)    Tissues (90)    Images (31)
Theiler Stages: 2, 3, 4, 5, 17, 20, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 152
Northern blot 13
Western blot 2
RT-PCR 11
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(99) Genomic(1) cDNA(94) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002053 (Evidence)
Ensembl Gene ModelENSMUSG00000020918 (Evidence)
Entrez Gene14534 (Evidence)
UniGene218837
DFCITC1574360, TC1615434
DoTSDT.101196402, DT.101305204, DT.101380894, DT.110524519, DT.110524531, DT.491156
NIA Mouse Gene IndexU033432
EC2.3.1.48
Consensus CDS ProjectCCDS25432.1, CCDS25433.1
International Mouse Knockout Project StatusKat2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002053 VEGA Gene Model | MGI Sequence Detail 7720 C57BL/6J ±  kb
transcript OTTMUST00000004166 VEGA | MGI Sequence Detail 3046 Not Applicable 
polypeptide OTTMUSP00000001993 VEGA | MGI Sequence Detail 830 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016181 Acyl-CoA N-acyltransferase
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR000182 GNAT domain
InterPro IPR016376 Histone acetylase PCAF
InterPro IPR009464 PCAF, N-terminal
Protein Ontology PR:000007902 histone acetyltransferase KAT2A
References (Earliest) J:57302 Xu W, et al., Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998 Oct;18(10):5659-69
(Latest) J:210620 Tao Y, et al., MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice. Br J Haematol. 2014 Jul;166(2):279-91
All references(65)
Other
accession IDs
MGI:1924162, MGI:2144513

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory