Kat2a
Gene Detail

Symbol Name ID

Kat2a K(lysine) acetyltransferase 2A MGI:1343101

Synonyms

1110051E14Rik, Gcn5, Gcn5l2, PCAF-B/GCN5

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:100704746-100712465 bp, - strand From VEGA annotation of GRCm38   7720 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41343  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: histone acetylase PCAF
Gene Tree: Kat2a

Human homologs

Human Homolog		KAT2A, K(lysine) acetyltransferase 2A
NCBI Gene ID		2648
neXtProt AC		NX_Q92830
Human Synonyms		GCN5, GCN5L2, hGCN5, PCAF-b
Human Chr (Location)		17q21; chr17:40265129-40273382 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(7) Gene trapped(5)
 

Homozygotes for targeted null mutations exhibit poorly developed yolk sac blood vessels, retarded growth, absence of dorsal mesoderm lineages, failure to form somites, and lethality between embryonic days 9.5-11.5.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	cell proliferation, histone acetylation, ...
Component	Ada2/Gcn5/Ada3 transcription activator complex, histone acetyltransferase complex, ...
Function	chromatin binding, H3 histone acetyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (185)    Tissues (94)    Images (31)
Theiler Stages: 2, 3, 4, 5, 17, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	152
Northern blot	13
Western blot	2
RT-PCR	18

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(99) Genomic(1) cDNA(94) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000002053 (Evidence)
Ensembl Gene Model	ENSMUSG00000020918 (Evidence)
Entrez Gene	14534 (Evidence)
UniGene	218837
DFCI	TC1574360, TC1615434
DoTS	DT.101196402, DT.101305204, DT.101380894, DT.110524519, DT.110524531, DT.491156
NIA Mouse Gene Index	U033432
EC	2.3.1.48
Consensus CDS Project	CCDS25432.1, CCDS25433.1
International Mouse Knockout Project Status	Kat2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002053	VEGA Gene Model | MGI Sequence Detail	7720	C57BL/6J
transcript	OTTMUST00000004166	VEGA | MGI Sequence Detail	3046	Not Applicable
polypeptide	OTTMUSP00000001993	VEGA | MGI Sequence Detail	830	Not Applicable

All sequences(66) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(17 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016181	Acyl-CoA N-acyltransferase
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR000182	GNAT domain
InterPro	IPR016376	Histone acetylase PCAF
InterPro	IPR009464	PCAF, N-terminal
Protein Ontology	PR:000007902	histone acetyltransferase KAT2A

References

(Earliest) J:57302 Xu W, et al., Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol. 1998 Oct;18(10):5659-69
(Latest) J:192958 Zelin E, et al., The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. Mol Cell. 2012 Nov 9;48(3):459-70
All references(60)

Other accession IDs

MGI:1924162, MGI:2144513