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Cstf2 Gene Detail
Summary
  • Symbol
    Cstf2
  • Name
    cleavage stimulation factor, 3' pre-RNA subunit 2
  • Synonyms
    C630034J23Rik, Cstf64
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343054
    NCBI Gene: 108062
  • Gene Overview
    MyGene.info: CSTF2
Location & Maps
more
  • Sequence Map
    ChrX:134059187-134086819 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27633 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 55.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CSTF2, cleavage stimulation factor subunit 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CSTF2, cleavage stimulation factor subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CstF-64
  • Links
    NCBI Gene ID: 1478
    neXtProt AC: NX_P33240

  • Chr Location
    Xq22.1; chrX:100820359-100841520 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 80171
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CSTF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    6
  • Targeted
    2
  • Incidental Mutations
    APF , CvDC
Embryonic stem cells (ESCs) hemizygous for a gene trap allele show a specific loss of differentiation potential toward the endodermal lineage and a severe defect in cardiomyocyte differentiation. Mutant ESCs differentiated into embryoid bodies fail to cavitate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019011 VEGA Gene Model | MGI Sequence Detail 27633 C57BL/6J ±  kb
transcript OTTMUST00000045619 VEGA | MGI Sequence Detail 4502 Not Applicable  
polypeptide OTTMUSP00000020509 VEGA | MGI Sequence Detail 580 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    89 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005976 cleavage stimulation factor subunit 2
  • InterPro Domains
    IPR033105 Cleavage stimulation factor subunit 2
    IPR025742 Cleavage stimulation factor subunit 2, hinge domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
    IPR026896 Transcription termination and cleavage factor, C-terminal domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 6
Other
Accession IDs
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MGI:2442983
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:36814 Takagaki Y, et al., The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell. 1996 Nov 29;87(5):941-52
  • Latest
    J:223072 Youngblood BA, et al., CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects. Stem Cell Res. 2014 Nov;13(3 Pt A):413-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory