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Cstf2 Gene Detail
Summary
  • Symbol
    Cstf2
  • Name
    cleavage stimulation factor, 3' pre-RNA subunit 2
  • Synonyms
    C630034J23Rik, Cstf64
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343054
    NCBI Gene: 108062
  • Gene Overview
    MyGene.info: CSTF2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134059187-134086819 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 55.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343054
protein coding gene ChrX:134059176-134086822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036060
protein coding gene ChrX:131207454-131236055 (+)
A/J MGP_AJ_G0036042
protein coding gene ChrX:130631589-130659199 (+)
AKR/J MGP_AKRJ_G0035961
protein coding gene ChrX:134801872-134831553 (+)
BALB/cJ MGP_BALBcJ_G0036033
protein coding gene ChrX:129078206-129105800 (+)
C3H/HeJ MGP_C3HHeJ_G0035737
protein coding gene ChrX:131284311-131312929 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036555
protein coding gene ChrX:135071401-135099055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033383
protein coding gene ChrX:122836823-122864467 (+)
CAST/EiJ MGP_CASTEiJ_G0035024
protein coding gene ChrX:112164643-112192899 (+)
CBA/J MGP_CBAJ_G0035714
protein coding gene ChrX:139113504-139141994 (+)
DBA/2J MGP_DBA2J_G0035867
protein coding gene ChrX:129970062-129997670 (+)
FVB/NJ MGP_FVBNJ_G0035809
protein coding gene ChrX:129279920-129308050 (+)
LP/J MGP_LPJ_G0035960
protein coding gene ChrX:132086192-132113803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035837
protein coding gene ChrX:146515453-146547164 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036584
protein coding gene ChrX:130640476-130668711 (+)
PWK/PhJ MGP_PWKPhJ_G0034716
protein coding gene ChrX:109121462-109149202 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034548
protein coding gene ChrX:112797112-112825088 (+)
WSB/EiJ MGP_WSBEiJ_G0035161
protein coding gene ChrX:129020584-129048787 (+)



Homology
more
  • Human Ortholog
    CSTF2, cleavage stimulation factor subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSTF2, cleavage stimulation factor subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CstF-64
  • Links
    NCBI Gene ID: 1478
    neXtProt AC: NX_P33240
    UniProt: P33240

  • Chr Location
    Xq22.1; chrX:100820359-100841520 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 80171
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CSTF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryonic stem cells (ESCs) hemizygous for a gene trap allele show a specific loss of differentiation potential toward the endodermal lineage and a severe defect in cardiomyocyte differentiation. Mutant ESCs differentiated into embryoid bodies fail to cavitate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031256 Ensembl Gene Model | MGI Sequence Detail 27633 C57BL/6J ±  kb
    transcript ENSMUST00000033609 Ensembl | MGI Sequence Detail 4502 Not Applicable  
    polypeptide ENSMUSP00000033609 Ensembl | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005976 cleavage stimulation factor subunit 2
    • InterPro Domains
      IPR033105 Cleavage stimulation factor subunit 2
      IPR025742 Cleavage stimulation factor subunit 2, hinge domain
      IPR038192 CSTF2, C-terminal domain superfamily
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR026896 Transcription termination and cleavage factor, C-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442983
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:36814 Takagaki Y, et al., The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell. 1996 Nov 29;87(5):941-52
    • Latest
      J:282329 Hildebrandt MR, et al., Cytoplasmic aggregation of DDX1 in developing embryos: Early embryonic lethality associated with Ddx1 knockout. Dev Biol. 2019 Nov 15;455(2):420-433

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory