Cstf2 MGI Mouse Gene Detail - MGI:1343054 - cleavage stimulation factor, 3' pre-RNA subunit 2

Symbol

Cstf2
Name

cleavage stimulation factor, 3' pre-RNA subunit 2
Synonyms

C630034J23Rik, Cstf64

Feature Type

protein coding gene
IDs

MGI:1343054
NCBI Gene: 108062
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:132959936-132987568 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 55.63 cM
Mapping Data

3 experiments

SNPs within 2kb

89 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1343054	protein coding gene	ChrX:132959925-132987571 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036060	protein coding gene	ChrX:131207454-131236055 (+)
A/J	MGP_AJ_G0036042	protein coding gene	ChrX:130631589-130659199 (+)
AKR/J	MGP_AKRJ_G0035961	protein coding gene	ChrX:134801872-134831553 (+)
BALB/cJ	MGP_BALBcJ_G0036033	protein coding gene	ChrX:129078206-129105800 (+)
C3H/HeJ	MGP_C3HHeJ_G0035737	protein coding gene	ChrX:131284311-131312929 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036555	protein coding gene	ChrX:135071401-135099055 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033383	protein coding gene	ChrX:122836823-122864467 (+)
CAST/EiJ	MGP_CASTEiJ_G0035024	protein coding gene	ChrX:112164643-112192899 (+)
CBA/J	MGP_CBAJ_G0035714	protein coding gene	ChrX:139113504-139141994 (+)
DBA/2J	MGP_DBA2J_G0035867	protein coding gene	ChrX:129970062-129997670 (+)
FVB/NJ	MGP_FVBNJ_G0035809	protein coding gene	ChrX:129279920-129308050 (+)
LP/J	MGP_LPJ_G0035960	protein coding gene	ChrX:132086192-132113803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035837	protein coding gene	ChrX:146515453-146547164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036584	protein coding gene	ChrX:130640476-130668711 (+)
PWK/PhJ	MGP_PWKPhJ_G0034716	protein coding gene	ChrX:109121462-109149202 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034548	protein coding gene	ChrX:112797112-112825088 (+)
WSB/EiJ	MGP_WSBEiJ_G0035161	protein coding gene	ChrX:129020584-129048787 (+)

Human Ortholog

CSTF2, cleavage stimulation factor subunit 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTF2, cleavage stimulation factor subunit 2
Synonyms

CstF-64, CSTF64, XLID113
Links

HGNC:2484

NCBI Gene ID: 1478

neXtProt AC: NX_P33240

UniProt: P33240
Chr Location

Xq22.1; chrX:100820391-100841520 (+) GRCh38

MGI Vertebrate Homology

Cstf2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CSTF2
Gene Tree

Cstf2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

6
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryonic stem cells (ESCs) hemizygous for a gene trap allele show a specific loss of differentiation potential toward the endodermal lineage and a severe defect in cardiomyocyte differentiation. Mutant ESCs differentiated into embryoid bodies fail to cavitate.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cstf2

ZFIN cenpi, cstf2

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All Sequences

70
RefSeq

10
UniProt

7
CCDS

CCDS30389.1, CCDS72430.1, CCDS81170.1

Ensembl

ENSMUSG00000031256 (Evidence)
NCBI Gene

108062

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031256	Ensembl Gene Model \| MGI Sequence Detail	27633	C57BL/6J	± kb
transcript	ENSMUST00000033609	Ensembl \| MGI Sequence Detail	4502	Not Applicable
polypeptide	ENSMUSP00000033609	Ensembl \| MGI Sequence Detail	580	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005976 cleavage stimulation factor subunit 2

(term hierarchy)
InterPro Domains

IPR025742 Cleavage stimulation factor subunit 2, hinge domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR026896 Transcription termination and cleavage factor, C-terminal domain

IPR038192 Transcription termination and cleavage factor, C-terminal domain superfamily

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All nucleic 14

cDNA 12

Primer pair 1

Other 1

Microarray probesets 6

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MGI:2442983

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:36814 Takagaki Y, et al., The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell. 1996 Nov 29;87(5):941-52
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Cstf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161985	ChrX:132959857-132959861 (+)	-77 bp
Tssr161986	ChrX:132959886-132959962 (+)	-12 bp
Tssr161987	ChrX:132960010-132960021 (+)	80 bp
Tssr161988	ChrX:132960064-132960115 (+)	154 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23