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Lrrfip1 Gene Detail
Summary
  • Symbol
    Lrrfip1
  • Name
    leucine rich repeat (in FLII) interacting protein 1
  • Synonyms
    FLAP (FLI LRR associated protein), Fliiap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342770
    NCBI Gene: 16978
  • Gene Overview
    MyGene.info: LRRFIP1
Location & Maps
more
  • Sequence Map
    Chr1:90998737-91128940 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      130204 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRRFIP1, leucine rich repeat (in FLII) interacting protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LRRFIP1, leucine rich repeat (in FLII) interacting protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FLAP1, FLAP-1, FLIIAP1, GCF2, GCF-2, HUFI-1, TRIP
  • Links
    NCBI Gene ID: 9208
    neXtProt AC: NX_Q32MZ4

  • Chr Location
    2q37.3; chr2:237627581-237781647 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Lrrfip1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048410 VEGA Gene Model | MGI Sequence Detail 130204 C57BL/6J ±  kb
transcript OTTMUST00000124110 VEGA | MGI Sequence Detail 3645 Not Applicable  
polypeptide OTTMUSP00000067590 VEGA | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1645 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000009942 leucine-rich repeat flightless-interacting protein 1
  • InterPro Domains
    IPR019139 Leucine-rich repeat flightless-interacting protein 1/2
Molecular
Reagents
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  • All nucleic 151
    cDNA 151

    Microarray probesets 7
Other
Accession IDs
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MGI:1277983, MGI:2138480
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:46846 Liu YT, et al., Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies. J Biol Chem. 1998 Apr 3;273(14):7920-7
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory