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Lrrfip1 Gene Detail
Summary
  • Symbol
    Lrrfip1
  • Name
    leucine rich repeat (in FLII) interacting protein 1
  • Synonyms
    FLAP (FLI LRR associated protein), Fliiap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342770
    NCBI Gene: 16978
  • Gene Overview
    MyGene.info: LRRFIP1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:90998737-91128944 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1645 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342770
protein coding gene Chr1:90998428-91128944 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016300
protein coding gene Chr1:92524047-92660821 (+)
A/J MGP_AJ_G0016281
protein coding gene Chr1:89189676-89324488 (+)
AKR/J MGP_AKRJ_G0016242
protein coding gene Chr1:91847977-91984933 (+)
BALB/cJ MGP_BALBcJ_G0016237
protein coding gene Chr1:89374442-89511555 (+)
C3H/HeJ MGP_C3HHeJ_G0016066
protein coding gene Chr1:92058452-92194424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016696
protein coding gene Chr1:96083684-96220775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014414
protein coding gene Chr1:83459373-83588537 (+)
CAST/EiJ MGP_CASTEiJ_G0015651
protein coding gene Chr1:91384884-91527224 (+)
CBA/J MGP_CBAJ_G0016042
protein coding gene Chr1:99150799-99293393 (+)
DBA/2J MGP_DBA2J_G0016145
protein coding gene Chr1:88423091-88553053 (+)
FVB/NJ MGP_FVBNJ_G0016144
protein coding gene Chr1:87446602-87583084 (+)
LP/J MGP_LPJ_G0016216
protein coding gene Chr1:93687801-93826112 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016169
protein coding gene Chr1:102408245-102548758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016736
protein coding gene Chr1:91869349-92006609 (+)
PWK/PhJ MGP_PWKPhJ_G0015435
protein coding gene Chr1:87832137-87965716 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015218
protein coding gene Chr1:90789983-90925382 (+)
WSB/EiJ MGP_WSBEiJ_G0015709
protein coding gene Chr1:91657082-91795268 (+)



Homology
more
  • Human Ortholog
    LRRFIP1, LRR binding FLII interacting protein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LRRFIP1, LRR binding FLII interacting protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FLAP1, FLAP-1, FLIIAP1, GCF2, GCF-2, HUFI-1, TRIP
  • Links
    NCBI Gene ID: 9208
    neXtProt AC: NX_Q32MZ4
    UniProt: Q32MZ4

  • Chr Location
    2q37.3; chr2:237627570-237781647 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026305 Ensembl Gene Model | MGI Sequence Detail 130208 C57BL/6J ±  kb
transcript ENSMUST00000097649 Ensembl | MGI Sequence Detail 3645 Not Applicable  
polypeptide ENSMUSP00000095254 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000009942 leucine-rich repeat flightless-interacting protein 1
  • InterPro Domains
    IPR019139 Leucine-rich repeat flightless-interacting protein 1/2
Molecular
Reagents
less
  • All nucleic 153
    Genomic 1
    cDNA 152

    Microarray probesets 7
Other
Accession IDs
less
MGI:1277983, MGI:2138480
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:238260 Liu TY, et al., Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017 Jan;7(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory