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Ikzf3 Gene Detail
Summary
  • Symbol
    Ikzf3
  • Name
    IKAROS family zinc finger 3
  • Synonyms
    5830411O07Rik, Aiolos, Zfpn1a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342542
    NCBI Gene: 22780
  • Gene Overview
    MyGene.info: IKZF3
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98464902-98546031 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342542
protein coding gene Chr11:98464610-98546374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019062
protein coding gene Chr11:101015207-101105886 (-)
A/J MGP_AJ_G0019030
protein coding gene Chr11:96811468-96894057 (-)
AKR/J MGP_AKRJ_G0019000
protein coding gene Chr11:99811862-99896781 (-)
BALB/cJ MGP_BALBcJ_G0019003
protein coding gene Chr11:97305414-97388290 (-)
C3H/HeJ MGP_C3HHeJ_G0018817
protein coding gene Chr11:99944736-100033363 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019456
protein coding gene Chr11:104099537-104191651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017087
protein coding gene Chr11:94251672-94333783 (-)
CAST/EiJ MGP_CASTEiJ_G0018371
protein coding gene Chr11:100832408-100918838 (-)
CBA/J MGP_CBAJ_G0018788
protein coding gene Chr11:108419255-108508351 (-)
DBA/2J MGP_DBA2J_G0018896
protein coding gene Chr11:96353944-96437236 (-)
FVB/NJ MGP_FVBNJ_G0018885
protein coding gene Chr11:95863653-95948470 (-)
LP/J MGP_LPJ_G0018966
protein coding gene Chr11:101489245-101577931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018912
protein coding gene Chr11:108201952-108287972 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019496
protein coding gene Chr11:100142661-100228245 (-)
PWK/PhJ MGP_PWKPhJ_G0018143
protein coding gene Chr11:97362375-97448148 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017933
protein coding gene Chr11:99843417-99925421 (-)
WSB/EiJ MGP_WSBEiJ_G0018421
protein coding gene Chr11:100058310-100155977 (-)



Homology
more
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AIO, AIOLOS, ZNFN1A3
  • Links
    NCBI Gene ID: 22806
    neXtProt AC: NX_Q9UKT9
    UniProt: Q9UKT9

  • Chr Location
    17q12-q21.1; chr17:39757715-39864188 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ikzf3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018168 Ensembl Gene Model | MGI Sequence Detail 81130 C57BL/6J ±  kb
    transcript ENSMUST00000103141 Ensembl | MGI Sequence Detail 3658 Not Applicable  
    polypeptide ENSMUSP00000099430 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926180, MGI:891998
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:40023 Morgan B, et al., Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15;16(8):2004-13
    • Latest
      J:260850 Kanagaratham C, et al., Loss of the zona pellucida-binding protein 2 (Zpbp2) gene in mice impacts airway hypersensitivity and lung lipid metabolism in a sex-dependent fashion. Mamm Genome. 2018 Apr;29(3-4):281-298

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory