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Ikzf3 Gene Detail
Summary
  • Symbol
    Ikzf3
  • Name
    IKAROS family zinc finger 3
  • Synonyms
    5830411O07Rik, Aiolos, Zfpn1a3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342542
    NCBI Gene: 22780
  • Gene Overview
    MyGene.info: IKZF3
Location & Maps
more
  • Sequence Map
    Chr11:98464902-98546031 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81130 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IKZF3, IKAROS family zinc finger 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIO, AIOLOS, ZNFN1A3
  • Links
    NCBI Gene ID: 22806
    neXtProt AC: NX_Q9UKT9

  • Chr Location
    17q21; chr17:39757715-39864188 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ikzf3 mouse models

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ikzf3
  • Incidental Mutations
Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006450 VEGA Gene Model | MGI Sequence Detail 81130 C57BL/6J ±  kb
transcript OTTMUST00000014738 VEGA | MGI Sequence Detail 3658 Not Applicable  
polypeptide OTTMUSP00000006848 VEGA | MGI Sequence Detail 507 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    232 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001976 zinc finger protein Aiolos
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 18
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1926180, MGI:891998
References
more
  • Summaries
    All 53
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 8
    Phenotypes 21
  • Earliest
    J:40023 Morgan B, et al., Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15;16(8):2004-13
  • Latest
    J:216674 Holmes ML, et al., Peripheral natural killer cell maturation depends on the transcription factor Aiolos. EMBO J. 2014 Nov 18;33(22):2721-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory