Ikzf3
Gene Detail

Symbol Name ID

Ikzf3 IKAROS family zinc finger 3 MGI:1342542

Synonyms

5830411O07Rik, Aiolos, Zfpn1a3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:98464902-98546031 bp, - strand From VEGA annotation of GRCm38   81130 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: ikaros-related zinc finger transcription factor
Gene Tree: Ikzf3

Human homologs

Human Homolog		IKZF3, IKAROS family zinc finger 3 (Aiolos)
NCBI Gene ID		22806
neXtProt AC		NX_Q9UKT9
Human Synonyms		AIO, AIOLOS, ZNFN1A3
Human Chr (Location)		17q21; chr17:37913968-38020441 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE.

 
Human Diseases Modeled Using Mouse Ikzf3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	B cell activation, regulation of apoptotic process, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (157)    Tissues (156)    Images (7)
Theiler Stages: 17, 18, 21, 22, 23, 28

Assay Type	Results
RNA in situ	157

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000006450 (Evidence)
Ensembl Gene Model	ENSMUSG00000018168 (Evidence)
Entrez Gene	22780 (Evidence)
DFCI	TC1597521, TC1601287, TC1655681, TC1677163, TC1695062
DoTS	DT.101128087, DT.101352707, DT.40134980, DT.484300, DT.485540, DT.55115738
NIA Mouse Gene Index	U033366
Consensus CDS Project	CCDS25352.1
International Mouse Knockout Project Status	Ikzf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006450	VEGA Gene Model | MGI Sequence Detail	81130	C57BL/6J
transcript	OTTMUST00000014738	VEGA | MGI Sequence Detail	3658	Not Applicable
polypeptide	OTTMUSP00000006848	VEGA | MGI Sequence Detail	507	Not Applicable

All sequences(48) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(206 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000001976	zinc finger protein aiolos

References

(Earliest) J:40023 Morgan B, et al., Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15;16(8):2004-13
(Latest) J:187634 Quintana FJ, et al., Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012;13(8):770-7
All references(52)

Other accession IDs

MGI:1926180, MGI:891998