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Ikzf3
Gene Detail
Symbol

Name
ID
Ikzf3
IKAROS family zinc finger 3
MGI:1342542
Synonyms
5830411O07Rik, Aiolos, Zfpn1a3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:98464902-98546031 bp, - strand
From VEGA annotation of GRCm38

  81130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: IKZF3
Protein SuperFamily: ikaros-related zinc finger transcription factor
Gene Tree: Ikzf3

Human
homologs
IKZF3, IKAROS family zinc finger 3 (Aiolos)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22806
neXtProt AC: NX_Q9UKT9

Human Synonyms: AIO, AIOLOS, ZNFN1A3

Human Chr (Location): 17q21; chr17:39757715-39864188 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Genomic Mutations involving Ikzf3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit greatly reduced B cell populations in the peritoneum, marginal zone and recirculating bone marrow. Aging mutants express autoantibodies, frequently develop B cell lymphomas, and display symptoms characteristic of SLE.
 
Human Diseases Modeled in Mice Using Ikzf3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ikzf3 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process B cell activation, positive regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (154)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000006450 (Evidence)
Ensembl Gene Model ENSMUSG00000018168 (Evidence)
Entrez Gene 22780 (Evidence)
DFCI TC1597521, TC1601287, TC1655681, TC1677163, TC1695062
DoTS DT.101128087, DT.101352707, DT.40134980, DT.484300, DT.485540, DT.55115738
NIA Mouse Gene Index U033366
Consensus CDS Project CCDS25352.1
International Mouse Phenotyping Consortium Status Ikzf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006450 VEGA Gene Model | MGI Sequence Detail 81130 C57BL/6J ±  kb
transcript OTTMUST00000014738 VEGA | MGI Sequence Detail 3658 Not Applicable 
polypeptide OTTMUSP00000006848 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(232 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001976 zinc finger protein Aiolos
References
(Earliest) J:40023 Morgan B, et al., Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15;16(8):2004-13
(Latest) J:216674 Holmes ML, et al., Peripheral natural killer cell maturation depends on the transcription factor Aiolos. EMBO J. 2014 Nov 18;33(22):2721-34
All references(57)
Disease annotation references (2)
Other
accession IDs
MGI:1926180, MGI:891998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory