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Asap1 Gene Detail
Summary
  • Symbol
    Asap1
  • Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain1
  • Synonyms
    Ddef1, mKIAA1249
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342335
    NCBI Gene: 13196
  • Gene Overview
    MyGene.info: ASAP1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:64086857-64382919 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 28.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2481 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342335
protein coding gene Chr15:64086840-64382941 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021896
protein coding gene Chr15:63557005-63868746 (-)
A/J MGP_AJ_G0021855
protein coding gene Chr15:61090109-61394144 (-)
AKR/J MGP_AKRJ_G0021837
protein coding gene Chr15:62783953-63088061 (-)
BALB/cJ MGP_BALBcJ_G0021862
protein coding gene Chr15:61312097-61611576 (-)
C3H/HeJ MGP_C3HHeJ_G0021636
protein coding gene Chr15:62946927-63261290 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022301
protein coding gene Chr15:66020075-66332488 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019840
protein coding gene Chr15:58001948-58292917 (-)
CAST/EiJ MGP_CASTEiJ_G0021154
protein coding gene Chr15:63610389-63923217 (-)
CBA/J MGP_CBAJ_G0021602
protein coding gene Chr15:68249341-68571018 (-)
DBA/2J MGP_DBA2J_G0021726
protein coding gene Chr15:60922659-61220735 (-)
FVB/NJ MGP_FVBNJ_G0021708
protein coding gene Chr15:59964406-60262724 (-)
LP/J MGP_LPJ_G0021798
protein coding gene Chr15:63436250-63732952 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021731
protein coding gene Chr15:73240507-73560547 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022323
protein coding gene Chr15:63207326-63513696 (-)
PWK/PhJ MGP_PWKPhJ_G0020896
protein coding gene Chr15:61024890-61327461 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020737
protein coding gene Chr15:63018262-63328183 (-)
WSB/EiJ MGP_WSBEiJ_G0021206
protein coding gene Chr15:63186977-63499852 (-)



Homology
more
  • Human Ortholog
    ASAP1, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ASAP1, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P
  • Links
    NCBI Gene ID: 50807
    neXtProt AC: NX_Q9ULH1
    UniProt: Q9ULH1

  • Chr Location
    8q24.21-q24.22; chr8:130052104-130443848 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7684
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ASAP1
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a gene trapped allele show perinatal lethality, reduced respiratory rate, fetal growth retardation, slow weight gain, delayed bone ossification, reduced adipogenesis and altered in vitro differentiation of mesenchymal progenitor cells into chondrocytes, adipocytes and osteoblasts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022377 Ensembl Gene Model | MGI Sequence Detail 296063 C57BL/6J ±  kb
    transcript ENSMUST00000177374 Ensembl | MGI Sequence Detail 4582 Not Applicable  
    polypeptide ENSMUSP00000134825 Ensembl | MGI Sequence Detail 1147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 27
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1333872, MGI:2146172
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 11
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:277387 Schreiber C, et al., Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling. PLoS Genet. 2019 Jun;15(6):e1008216

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory