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Dazl
Gene Detail
 Symbol
Name
ID
Dazl
deleted in azoospermia-like
MGI:1342328
Synonyms Dazla, Daz-like, Tpx2, Tpx-2
Feature Type protein coding gene
Genetic Map
Chromosome 17
25.86 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:50279394-50293599 bp, - strand
From NCBI annotation of GRCm38

  14206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Dazl

Human
homologs
Human Homolog DAZ2, deleted in azoospermia 2
NCBI Gene ID 57055
neXtProt AC  NX_Q13117
Human Synonyms  pDP1678
Human Chr (Location)  Yq11.223; chrY:23219457-23291356 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DAZ2
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, female meiosis II, ...
Component cytoplasm, polysome
Function identical protein binding, mRNA 3'-UTR binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (143)    Tissues (52)    Images (14)
Theiler Stages: 2, 3, 4, 5, 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 23
Northern blot 21
Western blot 7
RT-PCR 90
cDNA source data(469)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(485) Genomic(3) cDNA(472) Primer pair(9) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000010592 (Evidence)
Entrez Gene13164 (Evidence)
UniGene280641
DFCITC1573870
DoTSDT.101177438, DT.40139012, DT.94149782
NIA Mouse Gene IndexU037906
PDB2XSF, 2XS2, 2XS5, 2XS7
Consensus CDS ProjectCCDS37649.1
International Mouse Knockout Project StatusDazl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13164 NCBI Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
transcript NM_010021 RefSeq | MGI Sequence Detail 2964 C57BL/6 
polypeptide Q64368 UniProt | EBI | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000006290 deleted in azoospermia-like
Graphical View of Protein Domain Structure
References (Earliest) J:11372 Kasahara M, et al., Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17. Immunogenetics. 1991;34(2):132-5
(Latest) J:194978 Reichmann J, et al., The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice. Hum Mol Genet. 2013 May 1;22(9):1791-806
All references(81)
Other
accession IDs
MGD-MRK-15212, MGD-MRK-15214, MGD-MRK-35375, MGI:106914, MGI:98816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory