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Dazl
Gene Detail
Symbol

Name
ID
Dazl
deleted in azoospermia-like
MGI:1342328
Synonyms
Dazla, Daz-like, Tpx2, Tpx-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
25.86 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:50279394-50293599 bp, - strand
From Ensembl annotation of GRCm38

  14206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86954  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DAZ2, DAZL
Gene Tree: Dazl

Human
homologs
DAZ2, deleted in azoospermia 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57055
neXtProt AC: NX_Q13117

Human Synonyms: pDP1678

Human Chr (Location): Yq11.223; chrY:23219457-23291356 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DAZ2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene.
 
Interactions
Dazl interacts with 277 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell differentiation, female meiosis II, ...
Component cytoplasm, polysome
Function identical protein binding, mRNA 3'-UTR binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (148)    Tissues (55)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 23
Northern blot 21
Western blot 7
RT-PCR 90
cDNA source data(469)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dazl ; ZFIN dazl    NEW 
Molecular
reagents
All nucleic(485) Genomic(3) cDNA(472) Primer pair(9) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000010592 (Evidence)
Entrez Gene 13164 (Evidence)
UniGene 280641
DFCI TC1573870
DoTS DT.40139012, DT.94149782, DT.101177438
NIA Mouse Gene Index U037906
PDB 2XSF, 2XS2, 2XS5, 2XS7
Consensus CDS Project CCDS37649.1
International Mouse Phenotyping Consortium Status Dazl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010592 Ensembl Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
transcript ENSMUST00000010736 Ensembl | MGI Sequence Detail 2942 Not Applicable 
polypeptide ENSMUSP00000010736 Ensembl | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000006290 deleted in azoospermia-like
References
(Earliest) J:11372 Kasahara M, et al., Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17. Immunogenetics. 1991;34(2):132-5
(Latest) J:219506 Kim S, et al., PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
All references(84)
Other
accession IDs
MGD-MRK-15212, MGD-MRK-15214, MGD-MRK-35375, MGI:106914, MGI:98816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory