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Dazl Gene Detail
Summary
  • Symbol
    Dazl
  • Name
    deleted in azoospermia-like
  • Synonyms
    Dazla, Daz-like, Tpx2, Tpx-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342328
    NCBI Gene: 13164
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:50279394-50293599 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14206 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.86 cM, cytoband B1
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DAZ2, deleted in azoospermia 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DAZ2, deleted in azoospermia 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    pDP1678
  • Links
    NCBI Gene ID: 57055
    neXtProt AC: NX_Q13117
    UniProt: Q13117

  • Chr Location
    Yq11.223; chrY:23219457-23291356 (+)  GRCh38.p7

  • Human Ortholog
    DAZL, deleted in azoospermia like
    Orthology source: HGNC
  • Synonyms
    DAZH, DAZL1, DAZLA, SPGYLA
  • Links
    NCBI Gene ID: 1618
    neXtProt AC: NX_Q92904
    UniProt: Q92904

  • Chr Location
    3p24.3; chr3:16586792-16605499 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DAZ2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010592 Ensembl Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
    transcript ENSMUST00000010736 Ensembl | MGI Sequence Detail 2942 Not Applicable  
    polypeptide ENSMUSP00000010736 Ensembl | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      79 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 487
      Genomic 3
      cDNA 472
      Primer pair 11
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15212, MGD-MRK-15214, MGD-MRK-35375, MGI:106914, MGI:98816
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 38
      Gene Ontology 13
      Phenotypes 27
    • Earliest
      J:11372 Kasahara M, et al., Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17. Immunogenetics. 1991;34(2):132-5
    • Latest
      J:244859 Liu W, et al., BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun. 2017 Jan 27;8(None):14182

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory