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Dazl Gene Detail
Summary
  • Symbol
    Dazl
  • Name
    deleted in azoospermia-like
  • Synonyms
    Dazla, Daz-like, Tpx2, Tpx-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342328
    NCBI Gene: 13164
Location & Maps
more
  • Sequence Map
    Chr17:50279394-50293599 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14206 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.86 cM, cytoband B1
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    DAZ2, deleted in azoospermia 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DAZ2, deleted in azoospermia 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    pDP1678
  • Links
    NCBI Gene ID: 57055
    neXtProt AC: NX_Q13117

  • Chr Location
    Yq11.223; chrY:23219457-23291356 (+)  GRCh38.p2

  • Human Ortholog
    DAZL, deleted in azoospermia like
    Orthology source: HGNC
  • Synonyms
    DAZH, DAZL1, DAZLA, SPGYLA
  • Links
    NCBI Gene ID: 1618
    neXtProt AC: NX_Q92904

  • Chr Location
    3p24.3; chr3:16586792-16605499 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DAZ2 associations

Human Disease Mouse Models
       Spermatogenic Failure, Y-Linked, 2; SPGFY2   OMIM: 415000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
Males homozygous for a targeted null mutation exhibit sterility with a complete absence of mature germ cells. In mutants, few spermatogonia enter meiosis, and those that do fail to proceed beyond pachytene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010592 Ensembl Gene Model | MGI Sequence Detail 14206 C57BL/6J ±  kb
transcript ENSMUST00000010736 Ensembl | MGI Sequence Detail 2942 Not Applicable  
polypeptide ENSMUSP00000010736 Ensembl | MGI Sequence Detail 298 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 486
    Genomic 3
    cDNA 472
    Primer pair 10
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-15212, MGD-MRK-15214, MGD-MRK-35375, MGI:106914, MGI:98816
References
more
  • Summaries
    All 88
    Developmental Gene Expression 34
    Gene Ontology 12
    Phenotypes 25
  • Earliest
    J:11372 Kasahara M, et al., Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17. Immunogenetics. 1991;34(2):132-5
  • Latest
    J:230563 Kato Y, et al., Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells. Nat Commun. 2016;7:11272

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory