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Ppef2 Gene Detail
Summary
  • Symbol
    Ppef2
  • Name
    protein phosphatase, EF hand calcium-binding domain 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342304
    NCBI Gene: 19023
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92374538-92404137 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 46.28 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    894 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342304
 protein coding gene Chr5:92374109-92404759 (-)
129S1/SvImJ ENSMUSG00200007194
 protein coding gene Chr5:88125296-88155003 (-)
A/J ENSMUSG00195024512
 protein coding gene Chr5:87277574-87307169 (-)
AKR/J ENSMUSG00220011521
 protein coding gene Chr5:87428113-87457718 (-)
BALB/cJ ENSMUSG00180021513
 protein coding gene Chr5:87122516-87152130 (-)
C3H/HeJ ENSMUSG00175041946
 protein coding gene Chr5:89223285-89252893 (-)
C57BL/6NJ ENSMUSG00215015776
 protein coding gene Chr5:87974813-88004420 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027411
 protein coding gene Chr5:85337466-85369942 (-)
CAST/EiJ ENSTCUG00005036462
 protein coding gene Chr5:86844323-86873488 (-)
CBA/J ENSMUSG00210006068
 protein coding gene Chr5:88002001-88031615 (-)
DBA/2J ENSMUSG00185037991
 protein coding gene Chr5:89938763-89968372 (-)
FVB/NJ ENSMUSG00205019514
 protein coding gene Chr5:86827454-86857066 (-)
JF1/MsJ ENSUMUG00000024532
 protein coding gene Chr5:94189621-94218738 (-)
LP/J ENSMUSG00230024122
 protein coding gene Chr5:94636500-94666213 (-)
NOD/ShiLtJ ENSMUSG00190035015
 protein coding gene Chr5:86906173-86935758 (-)
NZO/HlLtJ ENSMUSG00225008427
 protein coding gene Chr5:99777450-99807033 (-)
PWK/PhJ ENSLUMG00010027666
 protein coding gene Chr5:86868231-86897328 (-)
SPRET/EiJ ENSMSPG00010031351
 protein coding gene Chr5:89240861-89267603 (-)
WSB/EiJ ENSIUOG00005026273
 protein coding gene Chr5:89900806-89930429 (-)



Homology
more
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
  • Synonyms
    PPP7CB
  • Links
    NCBI Gene ID: 5470
    UniProt: O14830

  • Chr Location
    4q21.1; chr4:75859864-75902571 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Ppef2
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    32 strains or lines available
Homozygotes for a targeted null mutation appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029410 Ensembl Gene Model | MGI Sequence Detail 29600 C57BL/6J ±  kb
transcript ENSMUST00000201130 Ensembl | MGI Sequence Detail 2878 Not Applicable  
polypeptide ENSMUSP00000144157 Ensembl | MGI Sequence Detail 757 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:373442 Zhou Y, et al., Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot. Sci Adv. 2025 Oct 10;11(41):eadt0836
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory