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Ppef2 Gene Detail
Summary
  • Symbol
    Ppef2
  • Name
    protein phosphatase, EF hand calcium-binding domain 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342304
    NCBI Gene: 19023
Location & Maps
more
  • Sequence Map
    Chr5:92226679-92256278 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29600 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.28 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPEF2, protein phosphatase with EF-hand domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP7CB
  • Links
    NCBI Gene ID: 5470
    neXtProt AC: NX_O14830

  • Chr Location
    4q21.1; chr4:75859872-75902528 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Ppef2
  • Incidental Mutations
Homozygotes for a targeted null mutation appear to be phenotypically normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055589 VEGA Gene Model | MGI Sequence Detail 29600 C57BL/6J ±  kb
transcript OTTMUST00000137577 VEGA | MGI Sequence Detail 2878 Not Applicable  
polypeptide OTTMUSP00000072434 VEGA | MGI Sequence Detail 757 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    106 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013067 serine/threonine-protein phosphatase with EF-hands 2
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR000048 IQ motif, EF-hand binding site
    IPR029052 Metallo-dependent phosphatase-like
    IPR013235 PPP domain
    IPR012008 Serine/threonine-protein phosphatase with EF-hands
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:43592 Sherman PM, et al., Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11639-44
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory