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Celf1 Gene Detail
Summary
  • Symbol
    Celf1
  • Name
    CUGBP, Elav-like family member 1
  • Synonyms
    1600010O03Rik, Brunol2, CUG-BP, Cugbp1, CUG-BP1, D2Wsu101e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342295
    NCBI Gene: 13046
  • Gene Overview
    MyGene.info: CELF1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:90940387-91019497 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.44 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342295
protein coding gene Chr2:90940382-91019497 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026137
protein coding gene Chr2:92229619-92320079 (+)
A/J MGP_AJ_G0026098
protein coding gene Chr2:88546678-88625407 (+)
AKR/J MGP_AKRJ_G0026079
protein coding gene Chr2:91000051-91080463 (+)
BALB/cJ MGP_BALBcJ_G0026107
protein coding gene Chr2:88709795-88790927 (+)
C3H/HeJ MGP_C3HHeJ_G0025858
protein coding gene Chr2:91272160-91355157 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026558
protein coding gene Chr2:95491006-95573310 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023949
protein coding gene Chr2:85065916-85144646 (+)
CAST/EiJ MGP_CASTEiJ_G0025323
protein coding gene Chr2:91797080-91877550 (+)
CBA/J MGP_CBAJ_G0025836
protein coding gene Chr2:98730237-98815824 (+)
DBA/2J MGP_DBA2J_G0025972
protein coding gene Chr2:88145347-88225055 (+)
FVB/NJ MGP_FVBNJ_G0025935
protein coding gene Chr2:87251917-87331331 (+)
LP/J MGP_LPJ_G0026076
protein coding gene Chr2:92441660-92526627 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025961
protein coding gene Chr2:101779469-101863840 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026612
protein coding gene Chr2:91051051-91135241 (+)
PWK/PhJ MGP_PWKPhJ_G0025058
protein coding gene Chr2:87869806-87949869 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024859
protein coding gene Chr2:90632930-90719708 (+)
WSB/EiJ MGP_WSBEiJ_G0025390
protein coding gene Chr2:91644984-91730014 (+)



Homology
more
  • Human Ortholog
    CELF1, CUGBP Elav-like family member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CELF1, CUGBP Elav-like family member 1
    Orthology source: HGNC
  • Synonyms
    BRUNOL2, CUGBP, CUG-BP, CUGBP1, EDEN-BP, hNab50, NAB50, NAPOR
  • Links
    NCBI Gene ID: 10658
    neXtProt AC: NX_Q92879
    UniProt: Q92879

  • Chr Location
    11p11.2; chr11:47465937-47565569 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene results in significant postnatal lethality, growth retardation, and impaired fertility in both sexes. Male infertility is caused by a blockage of spermiogenesis at stage 7 and increased germ cell apoptosis but is not fully penetrant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13046 NCBI Gene Model | MGI Sequence Detail 79111 C57BL/6J ±  kb
    transcript NM_001244891 RefSeq | MGI Sequence Detail 7849 C57BL/6  
    polypeptide P28659 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 2
      cDNA 30
      Primer pair 5
      Other 2

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-34246, MGI:106552, MGI:1923754, MGI:2138743
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261250 Siddam AD, et al., The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet. 2018 Mar;14(3):e1007278

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory