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Celf1 Gene Detail
Summary
  • Symbol
    Celf1
  • Name
    CUGBP, Elav-like family member 1
  • Synonyms
    1600010O03Rik, Brunol2, CUG-BP, Cugbp1, CUG-BP1, D2Wsu101e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342295
    NCBI Gene: 13046
  • Gene Overview
    MyGene.info: CELF1
Location & Maps
more
  • Sequence Map
    Chr2:90940382-91019497 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79116 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.44 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CELF1, CUGBP, Elav-like family member 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CELF1, CUGBP, Elav-like family member 1
    Orthology source: HGNC
  • Synonyms
    BRUNOL2, CUGBP, CUG-BP, CUGBP1, EDEN-BP, hNab50, NAB50, NAPOR
  • Links
    NCBI Gene ID: 10658
    neXtProt AC: NX_Q92879

  • Chr Location
    11p11; chr11:47465937-47565569 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    207
  • Chemically induced (other)
    1
  • Gene trapped
    197
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    3
  • Genomic Mutations
    4 involving Celf1
  • Incidental Mutations
Homozygous disruption of this gene results in significant postnatal lethality, growth retardation, and impaired fertility in both sexes. Male infertility is caused by a blockage of spermiogenesis at stage 7 and increased germ cell apoptosis but is not fully penetrant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014337 VEGA Gene Model | MGI Sequence Detail 79116 C57BL/6J ±  kb
transcript OTTMUST00000033845 VEGA | MGI Sequence Detail 7800 Not Applicable  
polypeptide OTTMUSP00000015155 VEGA | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    168 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003439 CUGBP Elav-like family member 1
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
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  • All nucleic 33
    Genomic 2
    cDNA 27
    Primer pair 3
    Other 1

    Microarray probesets 12
Other
Accession IDs
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MGD-MRK-34246, MGI:106552, MGI:1923754, MGI:2138743
References
more
  • Summaries
    All 58
    Developmental Gene Expression 11
    Diseases 3
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:52091 Alexander BJ, et al., Gene deletion explains both in vivo and in vitro generated chromosome 2 aberrations associated with murine myeloid leukemia. Leukemia. 1995 Dec;9(12):2009-15
  • Latest
    J:228229 Boulanger G, et al., Hypogonadism Associated with Cyp19a1 (Aromatase) Posttranscriptional Upregulation in Celf1 Knockout Mice. Mol Cell Biol. 2015 Sep;35(18):3244-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory