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Celf1
Gene Detail
Symbol

Name
ID
Celf1
CUGBP, Elav-like family member 1
MGI:1342295
Synonyms
1600010O03Rik, Brunol2, CUG-BP, Cugbp1, CUG-BP1, D2Wsu101e
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:90940382-91019497 bp, + strand
From VEGA annotation of GRCm38

  79116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134102  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Celf1

Mutations,
alleles, and
phenotypes
All mutations/alleles(202) : Gene trapped(197) Targeted(5)
Genomic Mutations involving Celf1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene results in significant postnatal lethality, growth retardation, and impaired fertility in both sexes. Male infertility is caused by a blockage of spermiogenesis at stage 7 and increased germ cell apoptosis but is not fully penetrant.
 
Interactions
Celf1 interacts with 522 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process mRNA processing, mRNA splice site selection, ...
Component cytoplasm, nucleus
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (161)    Tissues (86)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 34
In situ reporter (knock in) 23
Western blot 45
RT-PCR 32
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(2) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(12)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014337 VEGA Gene Model | MGI Sequence Detail 79116 C57BL/6J ±  kb
transcript OTTMUST00000033845 VEGA | MGI Sequence Detail 7800 Not Applicable 
polypeptide OTTMUSP00000015155 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(149) RefSeq(28) UniProt(1)
Polymorphisms
SNPs within 2kb(173 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000003439 CUGBP Elav-like family member 1
References
(Earliest) J:52091 Alexander BJ, et al., Gene deletion explains both in vivo and in vitro generated chromosome 2 aberrations associated with murine myeloid leukemia. Leukemia. 1995 Dec;9(12):2009-15
(Latest) J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
All references(60)
Other
accession IDs
MGD-MRK-34246, MGI:106552, MGI:1923754, MGI:2138743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory