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Celf1
Gene Detail
Symbol

Name
ID
Celf1
CUGBP, Elav-like family member 1
MGI:1342295
Synonyms
1600010O03Rik, Brunol2, CUG-BP, Cugbp1, CUG-BP1, D2Wsu101e
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:90940382-91019497 bp, + strand
From VEGA annotation of GRCm38

  79116 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134102  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CELF1
Gene Tree: Celf1

Human
homologs
CELF1, CUGBP, Elav-like family member 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 10658
neXtProt AC: NX_Q92879

Human Synonyms: BRUNOL2, CUGBP, CUG-BP, CUGBP1, EDEN-BP, hNab50, NAB50, NAPOR

Human Chr (Location): 11p11; chr11:47465937-47565569 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(204) : Gene trapped(197) Targeted(5) Transgenic(2)
Genomic Mutations involving Celf1 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this gene results in significant postnatal lethality, growth retardation, and impaired fertility in both sexes. Male infertility is caused by a blockage of spermiogenesis at stage 7 and increased germ cell apoptosis but is not fully penetrant.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Celf1 interacts with 522 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process mRNA processing, mRNA splice site selection, ...
Component cytoplasm, nucleus
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (161)    Tissues (89)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 27
RNA in situ 34
In situ reporter (knock in) 23
Western blot 45
RT-PCR 32
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CELF1 ; Xenbase celf1    NEW 
Molecular
reagents
All nucleic(33) Genomic(2) cDNA(27) Primer pair(3) Other(1)
Microarray probesets(12)
Other database
links
VEGA Gene Model OTTMUSG00000014337 (Evidence)
Ensembl Gene Model ENSMUSG00000005506 (Evidence)
Entrez Gene 13046 (Evidence)
DFCI TC1646137, TC1694292, TC1633360, TC1653292, TC1614076, TC1624402, TC1574570, TC1589277
DoTS DT.103583695, DT.55180602, DT.101399312, DT.101399311, DT.492259, DT.533337, DT.101399310, DT.110697941, DT.101298402, DT.97399599, DT.94390818, DT.94325836, DT.91358078, DT.99861252
NIA Mouse Gene Index U042328
Consensus CDS Project CCDS16420.1, CCDS16421.1
International Mouse Phenotyping Consortium Status Celf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014337 VEGA Gene Model | MGI Sequence Detail 79116 C57BL/6J ±  kb
transcript OTTMUST00000033845 VEGA | MGI Sequence Detail 7800 Not Applicable 
polypeptide OTTMUSP00000015155 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(148) RefSeq(26) UniProt(1)
Polymorphisms
SNPs within 2kb(173 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000003439 CUGBP Elav-like family member 1
References
(Earliest) J:52091 Alexander BJ, et al., Gene deletion explains both in vivo and in vitro generated chromosome 2 aberrations associated with murine myeloid leukemia. Leukemia. 1995 Dec;9(12):2009-15
(Latest) J:204526 Kim YK, et al., Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity. Hum Mol Genet. 2014 Jan 15;23(2):293-302
All references(60)
Other
accession IDs
MGD-MRK-34246, MGI:106552, MGI:1923754, MGI:2138743

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory