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Uri1 Gene Detail
Summary
  • Symbol
    Uri1
  • Name
    URI1, prefoldin-like chaperone
  • Synonyms
    C80913, NNX3, Rmp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342294
    NCBI Gene: 19777
  • Gene Overview
    MyGene.info: URI1
Location & Maps
more
  • Sequence Map
    Chr7:37959992-38023551 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63560 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 25.29 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    URI1, URI1, prefoldin like chaperone
  • Vertebrate Orthologs
    10
  • Human Ortholog
    URI1, URI1, prefoldin like chaperone
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C19orf2, NNX3, PPP1R19, RMP, URI
  • Links
    NCBI Gene ID: 8725
    neXtProt AC: NX_O94763

  • Chr Location
    19q12; chr19:29923644-30016612 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2813
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: URI1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    71
  • Gene trapped
    67
  • Targeted
    4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042426 VEGA Gene Model | MGI Sequence Detail 63560 C57BL/6J ±  kb
transcript OTTMUST00000143111 VEGA | MGI Sequence Detail 1753 Not Applicable  
polypeptide OTTMUSP00000074618 VEGA | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    490 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014041 unconventional prefoldin RPB5 interactor 1
  • InterPro Domains
    IPR009053 Prefoldin
    IPR004127 Prefoldin alpha-like
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 18
    Primer pair 2

    Microarray probesets 9
Other
Accession IDs
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MGI:2142349
References
more
  • Summaries
    All 40
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:52000 Van Leuven F, et al., Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. Genomics. 1998 Dec 15;54(3):511-20
  • Latest
    J:217463 Tummala KS, et al., Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage. Cancer Cell. 2014 Dec 8;26(6):826-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory