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Lat
Gene Detail
 Symbol
Name
ID
Lat
linker for activation of T cells
MGI:1342293
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:126363827-126369534 bp, - strand
From NCBI annotation of GRCm38

  5708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7811  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Lat

Human
homologs
Human Homolog LAT, linker for activation of T cells
NCBI Gene ID 27040
neXtProt AC  NX_O43561
Human Synonyms  LAT1, pp36
Human Chr (Location)  16p11.2; chr16:28984826-28990783 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(1) Targeted(17)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit blockage of intra-thymic lymphocyte development at the double negative stage and absence of mature peripheral T cells.
 
Interactions
Lat interacts with 49 markers (Mir1b, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process calcium-mediated signaling, cellular defense response, ...
Component cell-cell junction, COP9 signalosome, ...
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (2)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 30
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030742 (Evidence)
Entrez Gene16797 (Evidence)
UniGene10280
DFCITC1582106
DoTSDT.97404642
NIA Mouse Gene IndexU029239
Consensus CDS ProjectCCDS21825.1
International Mouse Knockout Project StatusLat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16797 NCBI Gene Model | MGI Sequence Detail 5708 C57BL/6J ±  kb
transcript NM_010689 RefSeq | MGI Sequence Detail 1260 Not Specified 
polypeptide O54957 UniProt | EBI | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008359 Linker-for-activation of T cells (LAT) protein
Protein Ontology PR:000009683 linker for activation of T-cells family member 1
Graphical View of Protein Domain Structure
References (Earliest) J:49412 Zhang W, et al., LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998 Aug;9(2):239-46
(Latest) J:209918 Sullivan SA, et al., The role of LAT-PLCgamma1 interaction in gammadelta T cell development and homeostasis. J Immunol. 2014 Mar 15;192(6):2865-74
All references(115)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory