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Lat Gene Detail
Summary
  • Symbol
    Lat
  • Name
    linker for activation of T cells
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342293
    NCBI Gene: 16797
  • Gene Overview
    MyGene.info: LAT
Location & Maps
more
  • Sequence Map
    Chr7:126363824-126369570 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5747 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LAT, linker for activation of T-cells
  • Vertebrate Orthologs
    7
  • Human Ortholog
    LAT, linker for activation of T-cells
    Orthology source: HomoloGene
  • Synonyms
    LAT1, pp36
  • Links
    NCBI Gene ID: 27040
    neXtProt AC: NX_O43561

  • Chr Location
    16p11.2; chr16:28984826-28990783 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    95 phenotypes from 14 alleles in 10 genetic backgrounds
    38 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    1
  • Targeted
    18
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations exhibit blockage of intra-thymic lymphocyte development at the double negative stage and absence of mature peripheral T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058212 VEGA Gene Model | MGI Sequence Detail 5747 C57BL/6J ±  kb
transcript OTTMUST00000142943 VEGA | MGI Sequence Detail 1235 Not Applicable  
polypeptide OTTMUSP00000074541 VEGA | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000009683 linker for activation of T-cells family member 1
  • InterPro Domains
    IPR008359 Linker-for-activation of T cells (LAT) protein
Molecular
Reagents
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  • All nucleic 20
    cDNA 20

    Microarray probesets 3
References
more
  • Summaries
    All 116
    Developmental Gene Expression 1
    Gene Ontology 12
    Phenotypes 77
  • Earliest
    J:49412 Zhang W, et al., LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998 Aug;9(2):239-46
  • Latest
    J:222628 Hao B, et al., An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. J Exp Med. 2015 May 4;212(5):809-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory