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Lat
Gene Detail
Symbol

Name
ID
Lat
linker for activation of T cells
MGI:1342293
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:126363832-126369543 bp, - strand
From Ensembl annotation of GRCm38

  5712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7811  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: LAT
Gene Tree: Lat

Human
homologs
LAT, linker for activation of T cells
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 27040
neXtProt AC: NX_O43561

Human Synonyms: LAT1, pp36

Human Chr (Location): 16p11.2; chr16:28984826-28990783 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(1) Targeted(18)
Incidental mutations (data from APF )
 
Homozygotes for targeted null mutations exhibit blockage of intra-thymic lymphocyte development at the double negative stage and absence of mature peripheral T cells.
 
Interactions
Lat interacts with 49 markers (Mir1b, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process adaptive immune response, calcium-mediated signaling, ...
Component cell-cell junction, COP9 signalosome, ...
Function protein binding, protein kinase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (2)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030742 (Evidence)
Entrez Gene 16797 (Evidence)
UniGene 10280
DFCI TC1582106
DoTS DT.97404642
NIA Mouse Gene Index U029239
Consensus CDS Project CCDS21825.1
International Mouse Phenotyping Consortium Status Lat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030742 Ensembl Gene Model | MGI Sequence Detail 5712 C57BL/6J ±  kb
transcript ENSMUST00000032997 Ensembl | MGI Sequence Detail 1239 Not Applicable 
polypeptide ENSMUSP00000032997 Ensembl | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008359 Linker-for-activation of T cells (LAT) protein
Protein Ontology PR:000009683 linker for activation of T-cells family member 1
References
(Earliest) J:49412 Zhang W, et al., LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998 Aug;9(2):239-46
(Latest) J:222037 Laffleur B, et al., Self-Restrained B Cells Arise following Membrane IgE Expression. Cell Rep. 2015 Feb 12;
All references(115)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory