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Hspa4
Gene Detail
Symbol

Name
ID
Hspa4
heat shock protein 4
MGI:1342292
Synonyms
70kDa, APG-2, Hsp110, Hsp70RY
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:53259814-53300457 bp, - strand
From VEGA annotation of GRCm38

  40644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HSPA4
Protein SuperFamily: heat shock protein, Hsp110 type
Gene Tree: Hspa4

Human
homologs
HSPA4, heat shock 70kDa protein 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3308
neXtProt AC: NX_P34932

Human Synonyms: APG-2, HEL-S-5a, HS24/P52, hsp70, hsp70RY, HSPH2, RY

Human Chr (Location): 5q31.1; chr5:133051970-133105017 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(96) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.
 
Interactions
Hspa4 interacts with 289 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process chaperone-mediated protein complex assembly, negative regulation of apoptotic process, ...
Component cytoplasm, cytosol, ...
Function activating transcription factor binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HSPA4 ; Xenbase hspa4 ; ZFIN hspa4a, hspa4b    NEW 
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(27)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000000056 (Evidence)
Ensembl Gene Model ENSMUSG00000020361 (Evidence)
Entrez Gene 15525 (Evidence)
DFCI TC1601367, TC1598227, TC1572256
DoTS DT.101707732, DT.55113018, DT.55100946, DT.101739108, DT.97346607
NIA Mouse Gene Index U032758
Consensus CDS Project CCDS24674.1
International Mouse Phenotyping Consortium Status Hspa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000056 VEGA Gene Model | MGI Sequence Detail 40644 C57BL/6J ±  kb
transcript OTTMUST00000000145 VEGA | MGI Sequence Detail 4618 Not Applicable 
polypeptide OTTMUSP00000000078 VEGA | MGI Sequence Detail 842 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(2) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018181 Heat shock protein 70, conserved site
InterPro IPR013126 Heat shock protein 70 family
Protein Ontology PR:000003414 heat shock 70 kDa protein 4
References
(Earliest) J:18539 Hatayama T, et al., Cellular localization of high-molecular-mass heat shock proteins in murine cells. Biochem Biophys Res Commun. 1994 May 16;200(3):1367-73
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(46)
Other
accession IDs
MGI:1096373, MGI:2144116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory