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Hspa4
Gene Detail
 Symbol
Name
ID
Hspa4
heat shock protein 4
MGI:1342292
Synonyms 70kDa, APG-2, Hsp110, Hsp70RY
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:53259814-53300457 bp, - strand
From VEGA annotation of GRCm38

  40644 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: heat shock protein, Hsp110 type
Gene Tree: Hspa4

Human
homologs
Human Homolog HSPA4, heat shock 70kDa protein 4
NCBI Gene ID 3308
neXtProt AC  NX_P34932
Human Synonyms  APG-2, HEL-S-5a, HS24/P52, hsp70, hsp70RY, HSPH2, RY
Human Chr (Location)  5q31.1; chr5:133051970-133105017 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(102) : Gene trapped(96) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.
 
Interactions
Hspa4 interacts with 289 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chaperone-mediated protein complex assembly, negative regulation of apoptotic process, ...
Component cytoplasm, cytosol, ...
Function activating transcription factor binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(27)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000000056 (Evidence)
Ensembl Gene ModelENSMUSG00000020361 (Evidence)
Entrez Gene15525 (Evidence)
DFCITC1572256, TC1598227, TC1601367
DoTSDT.101707732, DT.101739108, DT.55100946, DT.55113018, DT.97346607
NIA Mouse Gene IndexU032758
Consensus CDS ProjectCCDS24674.1
International Mouse Knockout Project StatusHspa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000056 VEGA Gene Model | MGI Sequence Detail 40644 C57BL/6J ±  kb
transcript OTTMUST00000000145 VEGA | MGI Sequence Detail 4618 Not Applicable 
polypeptide OTTMUSP00000000078 VEGA | MGI Sequence Detail 842 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018181 Heat shock protein 70, conserved site
InterPro IPR013126 Heat shock protein 70 family
Protein Ontology PR:000003414 heat shock 70 kDa protein 4
References (Earliest) J:18539 Hatayama T, et al., Cellular localization of high-molecular-mass heat shock proteins in murine cells. Biochem Biophys Res Commun. 1994 May 16;200(3):1367-73
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(47)
Other
accession IDs
MGI:1096373, MGI:2144116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory