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Hspa4 Gene Detail
Summary
  • Symbol
    Hspa4
  • Name
    heat shock protein 4
  • Synonyms
    70kDa, APG-2, Hsp110, Hsp70RY
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342292
    NCBI Gene: 15525
  • Gene Overview
    MyGene.info: HSPA4
Location & Maps
more
  • Sequence Map
    Chr11:53259814-53300457 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40644 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 31.91 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
    Orthology source: HomoloGene
  • Synonyms
    APG-2, HEL-S-5a, HS24/P52, hsp70, hsp70RY, HSPH2, RY
  • Links
    NCBI Gene ID: 3308
    neXtProt AC: NX_P34932

  • Chr Location
    5q31.1; chr5:133051970-133105017 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    103
  • Chemically induced (other)
    1
  • Gene trapped
    96
  • Targeted
    6
  • Genomic Mutations
    1 involving Hspa4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000056 VEGA Gene Model | MGI Sequence Detail 40644 C57BL/6J ±  kb
transcript OTTMUST00000000145 VEGA | MGI Sequence Detail 4618 Not Applicable  
polypeptide OTTMUSP00000000078 VEGA | MGI Sequence Detail 842 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    70 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003414 heat shock 70 kDa protein 4
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain
    IPR029047 Heat shock protein 70kD, peptide-binding domain
Molecular
Reagents
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  • All nucleic 29
    Genomic 2
    cDNA 27

    Microarray probesets 9
Other
Accession IDs
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MGI:1096373, MGI:2144116
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:18539 Hatayama T, et al., Cellular localization of high-molecular-mass heat shock proteins in murine cells. Biochem Biophys Res Commun. 1994 May 16;200(3):1367-73
  • Latest
    J:231873 Mohamed BA, et al., Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice. Am J Respir Cell Mol Biol. 2014 Apr;50(4):817-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory