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Lbx2 Gene Detail
Summary
  • Symbol
    Lbx2
  • Name
    ladybird homeobox 2
  • Synonyms
    Lbx2h
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342288
    NCBI Gene: 16815
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83063348-83065224 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342288
 protein coding gene Chr6:83063346-83065224 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030916
 protein coding gene Chr6:84090124-84091987 (+)
A/J MGP_AJ_G0030885
 protein coding gene Chr6:80877224-80879135 (+)
AKR/J MGP_AKRJ_G0030813
 protein coding gene Chr6:83206106-83208003 (+)
BALB/cJ MGP_BALBcJ_G0030895
 protein coding gene Chr6:80890466-80892371 (+)
C3H/HeJ MGP_C3HHeJ_G0030815
 protein coding gene Chr6:101172725-101174897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031355
 protein coding gene Chr6:86374280-86377459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028541
 protein coding gene Chr6:79235600-79237484 (+)
CAST/EiJ MGP_CASTEiJ_G0030004
 protein coding gene Chr6:83214860-83216692 (+)
CBA/J MGP_CBAJ_G0030582
 protein coding gene Chr6:89783306-89785116 (+)
DBA/2J MGP_DBA2J_G0030735
 protein coding gene Chr6:80197334-80199147 (+)
FVB/NJ MGP_FVBNJ_G0030688
 protein coding gene Chr6:79404343-79406735 (+)
LP/J MGP_LPJ_G0030814
 protein coding gene Chr6:84085015-84086854 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030724
 protein coding gene Chr6:94090439-94093625 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031379
 protein coding gene Chr6:83021369-83023150 (+)
PWK/PhJ MGP_PWKPhJ_G0029719
 protein coding gene Chr6:79089965-79092139 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029547
 protein coding gene Chr6:81865535-81868193 (+)
WSB/EiJ MGP_WSBEiJ_G0030085
 protein coding gene Chr6:83459190-83461873 (+)



Homology
more
  • Human Ortholog
    LBX2, ladybird homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LBX2, ladybird homeobox 2
  • Synonyms
    LP3727
  • Links
    NCBI Gene ID: 85474
    neXtProt AC: NX_Q6XYB7
    UniProt: Q6XYB7

  • Chr Location
    2p13.1; chr2:74497517-74503316 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    9
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Lbx2
  • Find Mice (IMSR)
    10 strains or lines available
Mice homozygous for a knock-out allele are viable, fertile and healthy with no gross developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    954
  • Tissues
    142
  • cDNA Data
    11
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034968 Ensembl Gene Model | MGI Sequence Detail 1877 C57BL/6J ±  kb
transcript ENSMUST00000041265 Ensembl | MGI Sequence Detail 817 Not Applicable  
polypeptide ENSMUSP00000047134 Ensembl | MGI Sequence Detail 195 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 11
    Primer pair 6

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 12
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:56365 Chen F, et al., Lbx2, a novel murine homeobox gene related to the Drosophila ladybird genes is expressed in the developing urogenital system, eye and brain. Mech Dev. 1999 Jun;84(1-2):181-4
  • Latest
    J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory