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Flii
Gene Detail
 Symbol
Name
ID
Flii
flightless I homolog (Drosophila)
MGI:1342286
Synonyms 3632430F08Rik, Fliih
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.81 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:60714123-60727263 bp, - strand
From VEGA annotation of GRCm38

  13141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Flii

Human
homologs
Human Homolog FLII, flightless I homolog (Drosophila)
NCBI Gene ID 2314
neXtProt AC  NX_Q13045
Human Synonyms  FLI, Fli1, FLIL
Human Chr (Location)  17p11.2; chr17:18244815-18258916 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Genomic Mutations involving Flii (2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out allele are able to initiate uterine implantation but degenerate rapidly thereafter. Heterozygous mutant mice display enhanced wound healing with increased epithelial migration and improved wound contraction.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Flii interacts with 41 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process actin cytoskeleton organization, actin filament severing, ...
Component cell junction, cytoplasm, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(198)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(198) cDNA(198)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000007748 (Evidence)
Ensembl Gene ModelENSMUSG00000002812 (Evidence)
Entrez Gene14248 (Evidence)
UniGene339755
DFCITC1572310, TC1664604
NIA Mouse Gene IndexU032871
Consensus CDS ProjectCCDS24795.1
International Mouse Knockout Project StatusFlii
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007748 VEGA Gene Model | MGI Sequence Detail 13141 C57BL/6J ±  kb
transcript OTTMUST00000017709 VEGA | MGI Sequence Detail 4060 Not Applicable 
polypeptide OTTMUSP00000008167 VEGA | MGI Sequence Detail 1271 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR007122 Villin/Gelsolin
Protein Ontology PR:000007554 protein flightless-1
References (Earliest) J:53207 Probst FJ, et al., A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2). Genomics. 1999 Feb 1;55(3):348-52
(Latest) J:208071 Ruzehaji N, et al., Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes. Diabetologia. 2014 Feb;57(2):402-12
All references(46)
Other
accession IDs
MGI:1921278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory