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Flii Gene Detail
Summary
  • Symbol
    Flii
  • Name
    flightless I actin binding protein
  • Synonyms
    3632430F08Rik, Fliih
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342286
    NCBI Gene: 14248
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60604969-60618089 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.81 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342286
protein coding gene Chr11:60604949-60618089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018422
protein coding gene Chr11:60628601-60641739 (-)
A/J MGP_AJ_G0018391
protein coding gene Chr11:58397112-58410246 (-)
AKR/J MGP_AKRJ_G0018361
protein coding gene Chr11:60250625-60263826 (-)
BALB/cJ MGP_BALBcJ_G0018362
protein coding gene Chr11:58694084-58707224 (-)
C3H/HeJ MGP_C3HHeJ_G0018175
protein coding gene Chr11:60185100-60198242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018814
protein coding gene Chr11:62549602-62562742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016460
protein coding gene Chr11:55539760-55553481 (-)
CAST/EiJ MGP_CASTEiJ_G0017732
protein coding gene Chr11:60282330-60295659 (-)
CBA/J MGP_CBAJ_G0018149
protein coding gene Chr11:65270410-65285961 (-)
DBA/2J MGP_DBA2J_G0018258
protein coding gene Chr11:57983644-57996779 (-)
FVB/NJ MGP_FVBNJ_G0018249
protein coding gene Chr11:57645879-57658996 (-)
LP/J MGP_LPJ_G0018331
protein coding gene Chr11:61206812-61221175 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018273
protein coding gene Chr11:66328424-66341563 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018855
protein coding gene Chr11:60341237-60354366 (-)
PWK/PhJ MGP_PWKPhJ_G0017505
protein coding gene Chr11:58561222-58574295 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017295
protein coding gene Chr11:60159814-60172980 (-)
WSB/EiJ MGP_WSBEiJ_G0017784
protein coding gene Chr11:59963271-59976384 (-)



Homology
more
  • Human Ortholog
    FLII, FLII actin remodeling protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLII, FLII actin remodeling protein
  • Synonyms
    CMD2J, FLI, Fli1, FLIL
  • Links
    NCBI Gene ID: 2314
    neXtProt AC: NX_Q13045
    UniProt: Q13045

  • Chr Location
    17p11.2; chr17:18244815-18259022 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human FLII associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are able to initiate uterine implantation but degenerate rapidly thereafter. Heterozygous mutant mice display enhanced wound healing with increased epithelial migration and improved wound contraction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14248 NCBI Gene Model | MGI Sequence Detail 13121 C57BL/6J ±  kb
    transcript NM_022009 RefSeq | MGI Sequence Detail 4071 ZRU/MplStud  
    polypeptide Q9JJ28 UniProt | EBI | MGI Sequence Detail 1271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 198
      cDNA 198

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921278
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 7
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:339459 Gonuguntla S, et al., Stress-induced pseudokinase TRB3 augments IL1beta signaling by interacting with Flightless homolog 1. J Biol Chem. 2023 Aug;299(8):104803

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory