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Flii
Gene Detail
Symbol

Name
ID
Flii
flightless I homolog (Drosophila)
MGI:1342286
Synonyms
3632430F08Rik, Fliih
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:60714123-60727263 bp, - strand
From VEGA annotation of GRCm38

  13141 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FLII
Gene Tree: Flii

Human
homologs
FLII, flightless I actin binding protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2314
neXtProt AC: NX_Q13045

Human Synonyms: FLI, Fli1, FLIL

Human Chr (Location): 17p11.2; chr17:18244815-18258916 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(2) Targeted(9)
Genomic Mutations involving Flii (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for a knock-out allele are able to initiate uterine implantation but degenerate rapidly thereafter. Heterozygous mutant mice display enhanced wound healing with increased epithelial migration and improved wound contraction.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Flii interacts with 41 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process actin cytoskeleton organization, actin filament severing, ...
Component brush border, cell junction, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(198)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase flii ; ZFIN flii    NEW 
Molecular
reagents
All nucleic(198) cDNA(198)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000007748 (Evidence)
Ensembl Gene Model ENSMUSG00000002812 (Evidence)
Entrez Gene 14248 (Evidence)
UniGene 339755
DFCI TC1572310, TC1656316, TC1664604
NIA Mouse Gene Index U032871
Consensus CDS Project CCDS24795.1
International Mouse Phenotyping Consortium Status Flii
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007748 VEGA Gene Model | MGI Sequence Detail 13141 C57BL/6J ±  kb
transcript OTTMUST00000017709 VEGA | MGI Sequence Detail 4060 Not Applicable 
polypeptide OTTMUSP00000008167 VEGA | MGI Sequence Detail 1271 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(114 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029006 ADF-H/Gelsolin-like domain
InterPro IPR007123 Gelsolin-like domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR029919 Protein flightless-1
InterPro IPR007122 Villin/Gelsolin
Protein Ontology PR:000007554 protein flightless-1
References
(Earliest) J:53207 Probst FJ, et al., A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2). Genomics. 1999 Feb 1;55(3):348-52
(Latest) J:208071 Ruzehaji N, et al., Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes. Diabetologia. 2014 Feb;57(2):402-12
All references(47)
Other
accession IDs
MGI:1921278

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory