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Slc34a2 Gene Detail
Summary
  • Symbol
    Slc34a2
  • Name
    solute carrier family 34 (sodium phosphate), member 2
  • Synonyms
    D5Ertd227e, NaPi-2b, Npt2b, type IIb Na/Picotransporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342284
    NCBI Gene: 20531
  • Gene Overview
    MyGene.info: SLC34A2
Location & Maps
more
  • Sequence Map
    Chr5:53038081-53071664 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33584 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 28.92 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC34A2, solute carrier family 34 member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC34A2, solute carrier family 34 member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NAPI-3B, NAPI-IIb, NPTIIb
  • Links
    NCBI Gene ID: 10568
    neXtProt AC: NX_O95436

  • Chr Location
    4p15.2; chr4:25655813-25678748 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SLC34A2 associations

Human Disease Mouse Models
       Pulmonary Alveolar Microlithiasis   OMIM: 265100
Testicular Microlithiasis   OMIM: 610441
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Slc34a2
  • Incidental Mutations
Homozygous null mice display embryonic lethality, embryonic growth arrest, failure of embryo turning and somitogenesis, impaired placental development and impaired yolk sac vascular remodeling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026277 VEGA Gene Model | MGI Sequence Detail 33584 C57BL/6J ±  kb
transcript OTTMUST00000064978 VEGA | MGI Sequence Detail 4176 Not Applicable  
polypeptide OTTMUSP00000032326 VEGA | MGI Sequence Detail 697 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    88 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003841 Sodium-dependent phosphate transport protein
    IPR029852 Sodium-dependent phosphate transport protein 2B
Molecular
Reagents
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  • All nucleic 59
    cDNA 58
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1098602, MGI:2140766
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 22
  • Earliest
    J:51212 Hilfiker H, et al., Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14564-9
  • Latest
    J:211926 Ohata Y, et al., Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice. J Bone Miner Res. 2014 Jul;29(7):1627-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory