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Slc12a7
Gene Detail
Symbol

Name
ID
Slc12a7
solute carrier family 12, member 7
MGI:1342283
Synonyms
Kcc4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:73763697-73816743 bp, + strand
From Ensembl annotation of GRCm38

  53047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc12a7

Human
homologs
Human Homolog SLC12A7, solute carrier family 12 (potassium/chloride transporter), member 7
NCBI Gene ID 10723
neXtProt AC  NX_Q9Y666
Human Synonyms  KCC4
Human Chr (Location)  5p15; chr5:1050374-1112057 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(50) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Hearing is severely impaired in homozygous mutant mice, which also exhibit renal tubular acidosis.
 
Interactions
Slc12a7 interacts with 235 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell volume homeostasis, ion transport, ...
Component cell, integral component of membrane, ...
Function cation:chloride symporter activity, potassium:chloride symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (1)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000017756 (Evidence)
Entrez Gene20499 (Evidence)
DFCITC1659716, TC1574890
DoTSDT.101338658, DT.110971593, DT.101350695, DT.91423692, DT.91364114, DT.533699, DT.94160248
NIA Mouse Gene IndexU015004
Consensus CDS ProjectCCDS26635.1
International Mouse Knockout Project StatusSlc12a7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017756 Ensembl Gene Model | MGI Sequence Detail 53047 C57BL/6J ±  kb
transcript ENSMUST00000017900 Ensembl | MGI Sequence Detail 5131 Not Applicable 
polypeptide ENSMUSP00000017900 Ensembl | MGI Sequence Detail 1083 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004841 Amino acid permease domain
InterPro IPR000076 K-Cl co-transporter
InterPro IPR004842 Na/K/Cl co-transporter superfamily
Protein Ontology PR:000014930 solute carrier family 12 member 7
References
(Earliest) J:55435 Mount DB, et al., Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem. 1999 Jun 4;274(23):16355-62
(Latest) J:199033 Weng TY, et al., Glycosylation regulates the function and membrane localization of KCC4. Biochim Biophys Acta. 2013 May;1833(5):1133-46
All references(41)
Other
accession IDs
MGI:2145148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory