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Slc12a7 Gene Detail
Summary
  • Symbol
    Slc12a7
  • Name
    solute carrier family 12, member 7
  • Synonyms
    Kcc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342283
    NCBI Gene: 20499
  • Gene Overview
    MyGene.info: SLC12A7
Location & Maps
more
  • Sequence Map
    Chr13:73763697-73816743 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC12A7, solute carrier family 12 member 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC12A7, solute carrier family 12 member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KCC4
  • Links
    NCBI Gene ID: 10723
    neXtProt AC: NX_Q9Y666

  • Chr Location
    5p15; chr5:1050374-1155747 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    54
  • Chemically induced (other)
    1
  • Gene trapped
    50
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc12a7
  • Incidental Mutations
Hearing is severely impaired in homozygous mutant mice, which also exhibit renal tubular acidosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017756 Ensembl Gene Model | MGI Sequence Detail 53047 C57BL/6J ±  kb
transcript ENSMUST00000017900 Ensembl | MGI Sequence Detail 5131 Not Applicable  
polypeptide ENSMUSP00000017900 Ensembl | MGI Sequence Detail 1083 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    674 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2145148
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:55435 Mount DB, et al., Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem. 1999 Jun 4;274(23):16355-62
  • Latest
    J:199033 Weng TY, et al., Glycosylation regulates the function and membrane localization of KCC4. Biochim Biophys Acta. 2013 May;1833(5):1133-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory