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Slc12a7
Gene Detail
Symbol

Name
ID
Slc12a7
solute carrier family 12, member 7
MGI:1342283
Synonyms
Kcc4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
40.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:73763697-73816743 bp, + strand
From Ensembl annotation of GRCm38

  53047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21312  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC12A7
Gene Tree: Slc12a7

Human
homologs
SLC12A7, solute carrier family 12 (potassium/chloride transporter), member 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10723
neXtProt AC: NX_Q9Y666

Human Synonyms: KCC4

Human Chr (Location): 5p15; chr5:1050374-1155747 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(50) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Hearing is severely impaired in homozygous mutant mice, which also exhibit renal tubular acidosis.
 
Interactions
Slc12a7 interacts with 235 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (1)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 8
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN slc12a7b    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000017756 (Evidence)
Entrez Gene 20499 (Evidence)
DFCI TC1574890, TC1659716
DoTS DT.101338658, DT.101350695, DT.110971593, DT.533699, DT.91364114, DT.91423692, DT.94160248
NIA Mouse Gene Index U015004
Consensus CDS Project CCDS26635.1
International Mouse Phenotyping Consortium Status Slc12a7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017756 Ensembl Gene Model | MGI Sequence Detail 53047 C57BL/6J ±  kb
transcript ENSMUST00000017900 Ensembl | MGI Sequence Detail 5131 Not Applicable 
polypeptide ENSMUSP00000017900 Ensembl | MGI Sequence Detail 1083 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(16) UniProt(2)
Polymorphisms
SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004841 Amino acid permease/ SLC12A domain
InterPro IPR000076 K/Cl co-transporter
InterPro IPR030354 K/Cl co-transporter 4
InterPro IPR004842 SLC12A transporter family
Protein Ontology PR:000014930 solute carrier family 12 member 7
References
(Earliest) J:55435 Mount DB, et al., Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem. 1999 Jun 4;274(23):16355-62
(Latest) J:199033 Weng TY, et al., Glycosylation regulates the function and membrane localization of KCC4. Biochim Biophys Acta. 2013 May;1833(5):1133-46
All references(40)
Other
accession IDs
MGI:2145148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory