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Slc25a15 Gene Detail
Summary
  • Symbol
    Slc25a15
  • Name
    solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
  • Synonyms
    D630044L02Rik, Ornt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342274
    NCBI Gene: 18408
Location & Maps
more
  • Sequence Map
    Chr8:22375551-22398597 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.26 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC25A15, solute carrier family 25 member 15
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC25A15, solute carrier family 25 member 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D13S327, HHH, ORC1, ORNT1
  • Links
    NCBI Gene ID: 10166
    neXtProt AC: NX_Q9Y619

  • Chr Location
    13q14; chr13:40789411-40812460 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC25A15 associations

Human Disease Mouse Models
       Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome   OMIM: 238970
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    11
  • Gene trapped
    7
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000060883 VEGA Gene Model | MGI Sequence Detail 23047 C57BL/6J ±  kb
transcript OTTMUST00000148796 VEGA | MGI Sequence Detail 3430 Not Applicable  
polypeptide OTTMUSP00000077301 VEGA | MGI Sequence Detail 301 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015010 mitochondrial ornithine transporter 1
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain
    IPR018108 Mitochondrial substrate/solute carrier
Molecular
Reagents
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  • All nucleic 53
    cDNA 52
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2444400
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:55475 Camacho JA, et al., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Nat Genet. 1999 Jun;22(2):151-8
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory