Gsto1
Gene Detail

Symbol Name ID

Gsto1 glutathione S-transferase omega 1 MGI:1342273

Synonyms

GSTX, p28

Feature Type

protein coding gene

Genetic Map

Chromosome 19

40.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:47854970-47864790 bp, + strand From VEGA annotation of GRCm38   9821 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37971  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Gsto1

Human homologs

Human Homolog		GSTO1, glutathione S-transferase omega 1
NCBI Gene ID		9446
neXtProt AC		NX_P78417
Human Synonyms		GSTO 1-1, GSTTLp28, P28, SPG-R
Human Chr (Location)		10q25.1; chr10:106013952-106027222 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Other(1)
 

Mice homozygous for a mutant allele do not display abnormal arsenate metabolism following acute arsenate exposure.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cellular response to arsenic-containing substance, L-ascorbic acid biosynthetic process, ...
Component	axon, basement membrane, ...
Function	glutathione dehydrogenase (ascorbate) activity, glutathione transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (154)    Tissues (113)    Images (32)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	148
Northern blot	6

cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(155) cDNA(153) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028264 (Evidence)
Ensembl Gene Model	ENSMUSG00000025068 (Evidence)
Entrez Gene	14873 (Evidence)
UniGene	378931
DFCI	TC1571996
DoTS	DT.101403781, DT.110845756, DT.495718, DT.97411684
NIA Mouse Gene Index	U019552
EC	1.20.4.2, 1.8.5.1, 2.5.1.18
Consensus CDS Project	CCDS29893.1
International Mouse Knockout Project Status	Gsto1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028264	VEGA Gene Model | MGI Sequence Detail	9821	C57BL/6J
transcript	OTTMUST00000070036	VEGA | MGI Sequence Detail	1182	Not Applicable
polypeptide	OTTMUSP00000035646	VEGA | MGI Sequence Detail	240	Not Applicable

All sequences(39) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(184 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR004046	Glutathione S-transferase, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR004045	Glutathione S-transferase, N-terminal
InterPro	IPR005442	Glutathione S-transferase, omega-class
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008303	glutathione S-transferase omega-1

References

(Earliest) J:53034 Kodym R, et al., The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins. J Biol Chem. 1999 Feb 19;274(8):5131-7
(Latest) J:178114 Pei L, et al., Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med. 2011;17(11):1466-72
All references(42)

Other accession IDs

MGI:2147425, MGI:2147485, MGI:2147644