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Uhmk1 Gene Detail
Summary
  • Symbol
    Uhmk1
  • Name
    U2AF homology motif (UHM) kinase 1
  • Synonyms
    C820018A03Rik, KIS, Kist, OTTMUSG00000021542
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341908
    NCBI Gene: 16589
  • Gene Overview
    MyGene.info: UHMK1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170199256-170215435 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.84 cM, cytoband H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341908
protein coding gene Chr1:170193420-170215435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016726
protein coding gene Chr1:175884768-175906664 (-)
A/J MGP_AJ_G0016706
protein coding gene Chr1:168693269-168715308 (-)
AKR/J MGP_AKRJ_G0016672
protein coding gene Chr1:173776337-173798429 (-)
BALB/cJ MGP_BALBcJ_G0016667
protein coding gene Chr1:169194158-169216007 (-)
C3H/HeJ MGP_C3HHeJ_G0016491
protein coding gene Chr1:174026119-174048106 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017128
protein coding gene Chr1:181714039-181736011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014837
protein coding gene Chr1:160448717-160470872 (-)
CAST/EiJ MGP_CASTEiJ_G0016071
protein coding gene Chr1:173657449-173679205 (-)
CBA/J MGP_CBAJ_G0016466
protein coding gene Chr1:188165106-188189665 (-)
DBA/2J MGP_DBA2J_G0016572
protein coding gene Chr1:167572326-167597750 (-)
FVB/NJ MGP_FVBNJ_G0016570
protein coding gene Chr1:165935555-165957777 (-)
LP/J MGP_LPJ_G0016643
protein coding gene Chr1:176940958-177044851 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016595
protein coding gene Chr1:195506985-195529678 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017165
protein coding gene Chr1:173667438-173689649 (-)
PWK/PhJ MGP_PWKPhJ_G0015857
protein coding gene Chr1:166805194-166827309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015643
protein coding gene Chr1:172420817-172442683 (-)
WSB/EiJ MGP_WSBEiJ_G0016133
protein coding gene Chr1:173785816-173809287 (-)



Homology
more
  • Human Ortholog
    UHMK1, U2AF homology motif kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UHMK1, U2AF homology motif kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIS, KIST, P-CIP2
  • Links
    NCBI Gene ID: 127933
    neXtProt AC: NX_Q8TAS1
    UniProt: Q8TAS1

  • Chr Location
    1q23.3; chr1:162497174-162529629 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with disruptions in this gene show accelerated development of neointima after arterial injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16589 NCBI Gene Model | MGI Sequence Detail 16180 C57BL/6J ±  kb
    transcript NM_010633 RefSeq | MGI Sequence Detail 7872 C57BL/6  
    polypeptide P97343 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2138124, MGI:2138247, MGI:2138467, MGI:3707359
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:51752 Maucuer A, et al., Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3100-4
    • Latest
      J:233532 Scekic-Zahirovic J, et al., Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. EMBO J. 2016 May 17;35(10):1077-97

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory