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Slc23a1 Gene Detail
Summary
  • Symbol
    Slc23a1
  • Name
    solute carrier family 23 (nucleobase transporters), member 1
  • Synonyms
    D18Ucla2, Slc23a2, SVCT1, YSPL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341903
    NCBI Gene: 20522
  • Gene Overview
    MyGene.info: SLC23A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:35614604-35627244 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12641 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.17 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC23A1, solute carrier family 23 member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC23A1, solute carrier family 23 member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLC23A2, SVCT1, YSPL3
  • Links
    NCBI Gene ID: 9963
    neXtProt AC: NX_Q9UHI7
    UniProt: Q9UHI7

  • Chr Location
    5q31.2; chr5:139367196-139384553 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal ascorbate homeostasis and early postnatal lethality associated with lethargy and lack of gastric milk. Heterozygous mice of homozgous dams exhibit a similar phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023952 VEGA Gene Model | MGI Sequence Detail 12641 C57BL/6J ±  kb
    transcript OTTMUST00000058542 VEGA | MGI Sequence Detail 3026 Not Applicable  
    polypeptide OTTMUSP00000028374 VEGA | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      63 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 38
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-5036, MGI:91192
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 3
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:263761 Eck PK, et al., Temporo-spacial microanatomical distribution of the murine sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in the kidney throughout development. Biochem Cell Biol. 2017 Jun;95(3):421-427

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory