Ccr9 MGI Mouse Gene Detail - MGI:1341902 - chemokine (C-C motif) receptor 9

Symbol

Ccr9
Name

chemokine (C-C motif) receptor 9
Synonyms

Cmkbr10, GPR-9-6

Feature Type

protein coding gene
IDs

MGI:1341902
NCBI Gene: 12769
Gene Overview

MyGene.info: CCR9
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr9:123767211-123783457 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 74.33 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

263 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341902	protein coding gene	Chr9:123678439-123784330 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035481	protein coding gene	Chr9:126735852-126835934 (+)
A/J	MGP_AJ_G0035462	protein coding gene	Chr9:121887181-121989845 (+)
AKR/J	MGP_AKRJ_G0035395	protein coding gene	Chr9:125155458-125255855 (+)
BALB/cJ	MGP_BALBcJ_G0035458	protein coding gene	Chr9:121820421-121917925 (+)
C3H/HeJ	MGP_C3HHeJ_G0035165	protein coding gene	Chr9:125600361-125701383 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035981	protein coding gene	Chr9:130236684-130341180 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032863	protein coding gene	Chr9:119000975-119096214 (+)
CAST/EiJ	MGP_CASTEiJ_G0034470	protein coding gene	Chr9:125627583-125751588 (+)
CBA/J	MGP_CBAJ_G0035133	protein coding gene	Chr9:134981857-135108158 (+)
DBA/2J	MGP_DBA2J_G0035292	protein coding gene	Chr9:121332712-121431583 (+)
FVB/NJ	MGP_FVBNJ_G0035239	protein coding gene	Chr9:120234418-120336906 (+)
LP/J	MGP_LPJ_G0035371	protein coding gene	Chr9:127140106-127237579 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035280	protein coding gene	Chr9:135787852-135915772 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036000	protein coding gene	Chr9:125614442-125722088 (+)
PWK/PhJ	MGP_PWKPhJ_G0034174	protein coding gene	Chr9:121782588-121889582 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034011	protein coding gene	Chr9:125727213-125826139 (+)
WSB/EiJ	MGP_WSBEiJ_G0034590	protein coding gene	Chr9:125457262-125557570 (+)

Human Ortholog

CCR9, C-C motif chemokine receptor 9

Vertebrate Orthologs

12

Human Ortholog

CCR9, C-C motif chemokine receptor 9
Orthology source: HomoloGene, HGNC
Synonyms

CC-CKR-9, CDw199, GPR28, GPR-9-6
Links

HGNC:1610

NCBI Gene ID: 10803

neXtProt AC: NX_P51686

UniProt: P51686
Chr Location

3p21.31; chr3:45886504-45903177 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 22546
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CCR9
Protein SuperFamily

chemokine receptor
Gene Tree

Ccr9

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Phenotype Summary

16 phenotypes from 4 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice have altered trafficing of lymphocytes to the intestine.

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All GO Annotations

22
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

741
Tissues

61
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CCR9

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Ccr9 interacts with 359 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS23662.1
UniGene

440604

Ensembl

ENSMUSG00000029530 (Evidence)
NCBI Gene

12769

			Length	Strain/Species	Flank
genomic	12769	NCBI Gene Model \| MGI Sequence Detail	16247	C57BL/6J	± kb
transcript	NM_001166625	RefSeq \| MGI Sequence Detail	4392	C57BL/6
polypeptide	Q9WUT7	UniProt \| EBI \| MGI Sequence Detail	369	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001205 C-C chemokine receptor type 9

(term hierarchy)
InterPro Domains

IPR004069 CC chemokine receptor 9

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 27

Genomic 1

cDNA 25

Primer pair 1

Microarray probesets 6

Summaries

All 73

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 37
Earliest

J:54920 Zaballos A, et al., Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J Immunol. 1999 May 15;162(10):5671-5
Latest

J:285498 Ennamorati M, et al., Intestinal microbes influence development of thymic lymphocytes in early life. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2570-2578

TSS for Ccr9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87932	Chr9:123766961-123766971 (+)	-245 bp
Tssr87933	Chr9:123767217-123767241 (+)	18 bp
Tssr87940	Chr9:123774596-123774601 (+)	7,388 bp
Tssr87941	Chr9:123774750-123774761 (+)	7,545 bp
Tssr87942	Chr9:123774800-123774810 (+)	7,594 bp
Tssr87943	Chr9:123774852-123774869 (+)	7,650 bp
Tssr87944	Chr9:123774962-123774973 (+)	7,757 bp
Tssr87945	Chr9:123775014-123775025 (+)	7,809 bp
Tssr87946	Chr9:123775030-123775041 (+)	7,825 bp
Tssr87950	Chr9:123781186-123781198 (+)	13,981 bp
Tssr87951	Chr9:123781202-123781249 (+)	14,015 bp
Tssr87952	Chr9:123781255-123781306 (+)	14,070 bp
Tssr87953	Chr9:123781403-123781420 (+)	14,201 bp
Tssr87954	Chr9:123781428-123781440 (+)	14,223 bp
Tssr87955	Chr9:123781456-123781472 (+)	14,253 bp
Tssr87956	Chr9:123781600-123781621 (+)	14,400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16