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Nmur1 Gene Detail
Summary
  • Symbol
    Nmur1
  • Name
    neuromedin U receptor 1
  • Synonyms
    FM-3, Gpr66, NMU1R, NmU-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341898
    NCBI Gene: 14767
  • Gene Overview
    MyGene.info: NMUR1
Location & Maps
more
  • Sequence Map
    Chr1:86386242-86388162 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1921 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.94 cM, cytoband C5
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NMUR1, neuromedin U receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NMUR1, neuromedin U receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FM3, (FM-3), FM-3, GPC-R, GPR66, NMU1R
  • Links
    NCBI Gene ID: 10316
    neXtProt AC: NX_Q9HB89

  • Chr Location
    2q37.1; chr2:231519907-231530471 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Nmur1
  • Incidental Mutations
Homozygous null mice are healthy and viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022669 VEGA Gene Model | MGI Sequence Detail 1921 C57BL/6J ±  kb
transcript OTTMUST00000054320 VEGA | MGI Sequence Detail 1322 Not Applicable  
polypeptide OTTMUSP00000025915 VEGA | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR005390 Neuromedin U receptor
    IPR005391 Neuromedin U receptor, type 1
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:50329 Tan CP, et al., Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors. Genomics. 1998 Sep 1;52(2):223-9
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory