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Zfr Gene Detail
Summary
  • Symbol
    Zfr
  • Name
    zinc finger RNA binding protein
  • Synonyms
    C920030H05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341890
    NCBI Gene: 22763
  • Gene Overview
    MyGene.info: ZFR
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:12117720-12185449 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 5.90 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341890
protein coding gene Chr15:12117720-12185683 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021734
protein coding gene Chr15:9339489-9409158 (+)
A/J MGP_AJ_G0021694
protein coding gene Chr15:9043953-9114015 (+)
AKR/J MGP_AKRJ_G0021672
protein coding gene Chr15:9290720-9362132 (+)
BALB/cJ MGP_BALBcJ_G0021701
protein coding gene Chr15:8954492-9024302 (+)
C3H/HeJ MGP_C3HHeJ_G0021477
protein coding gene Chr15:9244965-9319221 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022140
protein coding gene Chr15:9684262-9760540 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019681
protein coding gene Chr15:8579141-8644600 (+)
CAST/EiJ MGP_CASTEiJ_G0020993
protein coding gene Chr15:9334789-9409473 (+)
CBA/J MGP_CBAJ_G0021446
protein coding gene Chr15:9963149-10040413 (+)
DBA/2J MGP_DBA2J_G0021570
protein coding gene Chr15:8895823-8971402 (+)
FVB/NJ MGP_FVBNJ_G0021548
protein coding gene Chr15:8754255-8824267 (+)
LP/J MGP_LPJ_G0021638
protein coding gene Chr15:9263831-9334564 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021573
protein coding gene Chr15:10194541-10279072 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022163
protein coding gene Chr15:9288110-9359015 (+)
PWK/PhJ MGP_PWKPhJ_G0020736
protein coding gene Chr15:9085419-9156148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020574
protein coding gene Chr15:9223503-9301644 (+)
WSB/EiJ MGP_WSBEiJ_G0021049
protein coding gene Chr15:9273856-9343162 (+)



Homology
more
  • Human Ortholog
    ZFR, zinc finger RNA binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFR, zinc finger RNA binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPG71, ZFR1
  • Links
    NCBI Gene ID: 51663
    neXtProt AC: NX_Q96KR1
    UniProt: Q96KR1

  • Chr Location
    5p13.3; chr5:32354350-32444738 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8009
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ZFR
  • Gene Tree
    Zfr
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired gastrulation, with increased apoptosis and a low mitotic index, and die between embryonic days 8 and 9.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22763 NCBI Gene Model | MGI Sequence Detail 67730 C57BL/6J ±  kb
    transcript NM_011767 RefSeq | MGI Sequence Detail 4612 C57BL/6  
    polypeptide O88532 UniProt | EBI | MGI Sequence Detail 1074 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      cDNA 171
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2441929
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:53504 Meagher MJ, et al., Identification of ZFR, an ancient and highly conserved murine chromosome-associated zinc finger protein. Gene. 1999 Mar 4;228(1-2):197-211
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory