Ajuba
Gene Detail

Symbol Name ID

Ajuba ajuba LIM protein MGI:1341886

Synonyms

Jub

Feature Type

protein coding gene

Genetic Map

Chromosome 14

27.84 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:54567469-54577661 bp, - strand From NCBI annotation of GRCm38   10193 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7789  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ajuba

Human homologs

Human Homolog		AJUBA, ajuba LIM protein
NCBI Gene ID		84962
neXtProt AC		NX_Q96IF1
Human Synonyms		JUB
Human Chr (Location)		14q11.2; chr14:23440409-23451851 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(62) : Targeted(3) Gene trapped(59)
 

Homozygous null mice are viable and reach adulthood without any obvious phenotypes, however mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	calcium-dependent cell-cell adhesion, cell adhesion, ...
Component	cell-cell junction, cell junction, ...
Function	actin filament binding, alpha-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (62)    Tissues (59)    Images (5)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	47
RT-PCR	15

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000022178 (Evidence)
Entrez Gene	16475 (Evidence)
UniGene	100253
DFCI	TC1581912, TC1589893
DoTS	DT.55253939, DT.94333952
NIA Mouse Gene Index	U035555
Consensus CDS Project	CCDS27093.1
International Mouse Knockout Project Status	Ajuba

Sequences

Length	Strain/Species
genomic	16475	NCBI Gene Model | MGI Sequence Detail	10193	C57BL/6J
transcript	NM_010590	RefSeq | MGI Sequence Detail	3503	C57BL/6
polypeptide	Q91XC0	UniProt | EBI | MGI Sequence Detail	547	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009231	protein ajuba

Graphical View of Protein Domain Structure

References

(Earliest) J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
(Latest) J:182886 Moik DV, et al., Loss of migfilin expression has no overt consequences on murine development and homeostasis. J Cell Sci. 2011 Feb 1;124(Pt 3):414-21
All references(49)