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Ajuba
Gene Detail
Symbol

Name
ID
Ajuba
ajuba LIM protein
MGI:1341886
Synonyms
Jub
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.84 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:54567469-54577661 bp, - strand
From NCBI annotation of GRCm38

  10193 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7789  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: AJUBA
Gene Tree: Ajuba

Human
homologs
AJUBA, ajuba LIM protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84962
neXtProt AC: NX_Q96IF1

Human Synonyms: JUB

Human Chr (Location): 14q11.2; chr14:22971174-22982642 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(59) Targeted(3)
Incidental mutations (data from APF )
 
Homozygous null mice are viable and reach adulthood without any obvious phenotypes, however mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro.
 
Interactions
Ajuba interacts with 200 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (55)    Tissues (54)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
RT-PCR 8
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ajuba    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000022178 (Evidence)
Entrez Gene 16475 (Evidence)
UniGene 100253
DFCI TC1581912, TC1589893
DoTS DT.55253939, DT.94333952
NIA Mouse Gene Index U035555
Consensus CDS Project CCDS27093.1
International Mouse Phenotyping Consortium Status Ajuba
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16475 NCBI Gene Model | MGI Sequence Detail 10193 C57BL/6J ±  kb
transcript NM_010590 RefSeq | MGI Sequence Detail 3503 C57BL/6 
polypeptide Q91XC0 UniProt | EBI | MGI Sequence Detail 547 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009231 protein ajuba
Graphical View of Protein Domain Structure
References
(Earliest) J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
(Latest) J:199301 Lavado A, et al., Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development. 2013 Aug;140(16):3323-34
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory