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Ajuba Gene Detail
Summary
  • Symbol
    Ajuba
  • Name
    ajuba LIM protein
  • Synonyms
    Jub
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341886
    NCBI Gene: 16475
  • Gene Overview
    MyGene.info: AJUBA
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54567472-54577558 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.84 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341886
protein coding gene Chr14:54567469-54577661 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021314
protein coding gene Chr14:48526720-48538257 (-)
A/J MGP_AJ_G0021273
protein coding gene Chr14:47579155-47590070 (-)
AKR/J MGP_AKRJ_G0021249
protein coding gene Chr14:49291855-49301910 (-)
BALB/cJ MGP_BALBcJ_G0021277
protein coding gene Chr14:47551120-47562051 (-)
C3H/HeJ MGP_C3HHeJ_G0021057
protein coding gene Chr14:48992609-49002811 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021716
protein coding gene Chr14:50993501-51004518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019260
protein coding gene Chr14:45993773-46004284 (-)
CAST/EiJ MGP_CASTEiJ_G0020576
protein coding gene Chr14:45232201-45242423 (-)
CBA/J MGP_CBAJ_G0021024
protein coding gene Chr14:52502532-52512660 (-)
DBA/2J MGP_DBA2J_G0021145
protein coding gene Chr14:47321073-47331137 (-)
FVB/NJ MGP_FVBNJ_G0021127
protein coding gene Chr14:46773840-46784093 (-)
LP/J MGP_LPJ_G0021219
protein coding gene Chr14:49533548-49543772 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021151
protein coding gene Chr14:51924447-51935922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021742
protein coding gene Chr14:48484830-48495965 (-)
PWK/PhJ MGP_PWKPhJ_G0020322
protein coding gene Chr14:43848610-43859092 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020150
protein coding gene Chr14:44468021-44478176 (-)
WSB/EiJ MGP_WSBEiJ_G0020629
protein coding gene Chr14:48778382-48788468 (-)



Homology
more
  • Human Ortholog
    AJUBA, ajuba LIM protein
  • Vertebrate Orthologs
    6
  • Human Ortholog
    AJUBA, ajuba LIM protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JUB
  • Links
    NCBI Gene ID: 84962
    neXtProt AC: NX_Q96IF1
    UniProt: Q96IF1

  • Chr Location
    14q11.2; chr14:22971174-22982642 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and reach adulthood without any obvious phenotypes, however mouse embryonic fibroblasts exhibit impaired cell migration and abnormal lamellipodia production in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022178 Ensembl Gene Model | MGI Sequence Detail 10087 C57BL/6J ±  kb
transcript ENSMUST00000054487 Ensembl | MGI Sequence Detail 3397 Not Applicable  
polypeptide ENSMUSP00000056977 Ensembl | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 55
    Developmental Gene Expression 11
    Gene Ontology 15
    Phenotypes 13
  • Earliest
    J:55014 Goyal RK, et al., Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen- activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89
  • Latest
    J:244304 Richardson R, et al., p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017 Jun;13(6):e1006828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory