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Gfra4 Gene Detail
Summary
  • Symbol
    Gfra4
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 4
  • Synonyms
    G630015H18Rik, GFR alpha-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341873
    NCBI Gene: 14588
Location & Maps
more
  • Sequence Map
    Chr2:131039632-131043088 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3457 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GFRA4, GDNF family receptor alpha 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GFRA4, GDNF family receptor alpha 4
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 64096
    neXtProt AC: NX_Q9GZZ7

  • Chr Location
    20p13-p12; chr20:3659292-3663399 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Gfra4
  • Incidental Mutations
Homozygotes for targeted null mutations are mice were viable, fertile, showed no overt anatomical defects. Thyroid tissue calcitonin content was reduced in null homozygotes and rate of bone formation was enhanced when in 129/B6 hybrid background strain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015542 VEGA Gene Model | MGI Sequence Detail 3457 C57BL/6J ±  kb
transcript OTTMUST00000036917 VEGA | MGI Sequence Detail 909 Not Applicable  
polypeptide OTTMUSP00000016563 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007951 GDNF family receptor alpha-4
  • InterPro Domains
    IPR016017 GDNF/GAS1
    IPR003438 Glial cell line-derived neurotrophic factor receptor
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2139291
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:53415 Gunn TM, et al., The mouse mahogany locus encodes a transmembrane form of human attractin. Nature. 1999 Mar 11;398(6723):152-6
  • Latest
    J:108404 Lindfors PH, et al., Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice. Endocrinology. 2006 May;147(5):2237-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory