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Rfc2 Gene Detail
Summary
  • Symbol
    Rfc2
  • Name
    replication factor C (activator 1) 2
  • Synonyms
    2610008M13Rik, 40kDa, 40kDa, Recc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341868
    NCBI Gene: 19718
  • Gene Overview
    MyGene.info: RFC2
Location & Maps
more
  • Sequence Map
    Chr5:134581366-134601805 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20440 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.68 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RFC2, replication factor C subunit 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RFC40
  • Links
    NCBI Gene ID: 5982
    neXtProt AC: NX_P35250

  • Chr Location
    7q11.23; chr7:74231485-74254458 (-)  GRCh38.p2

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    25
  • Endonuclease-mediated
    1
  • Gene trapped
    22
  • Targeted
    2
  • Genomic Mutations
    2 involving Rfc2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055749 VEGA Gene Model | MGI Sequence Detail 20440 C57BL/6J ±  kb
transcript OTTMUST00000137952 VEGA | MGI Sequence Detail 4995 Not Applicable  
polypeptide OTTMUSP00000072586 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013906 replication factor C subunit 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR013748 Replication factor C, C-terminal
Molecular
Reagents
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  • All nucleic 137
    Genomic 3
    cDNA 133
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13826, MGI:1913827, MGI:2140845, MGI:97892
References
more
  • Summaries
    All 38
    Diseases 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:40897 Bunz F, et al., cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11014-8
  • Latest
    J:202812 Vannier JB, et al., RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science. 2013 Oct 11;342(6155):239-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory