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Rfc2 Gene Detail
Summary
  • Symbol
    Rfc2
  • Name
    replication factor C (activator 1) 2
  • Synonyms
    2610008M13Rik, 40kDa, 40kDa, Recc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341868
    NCBI Gene: 19718
  • Gene Overview
    MyGene.info: RFC2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134582690-134598328 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.68 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341868
protein coding gene Chr5:134581366-134601805 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030159
protein coding gene Chr5:138998343-139022153 (+)
A/J MGP_AJ_G0030127
protein coding gene Chr5:133098120-133120233 (+)
AKR/J MGP_AKRJ_G0030060
protein coding gene Chr5:137414911-137437418 (+)
BALB/cJ MGP_BALBcJ_G0030137
protein coding gene Chr5:134439752-134465524 (+)
C3H/HeJ MGP_C3HHeJ_G0029853
protein coding gene Chr5:137963214-137986969 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030590
protein coding gene Chr5:144222549-144251886 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027814
protein coding gene Chr5:127379156-127401609 (+)
CAST/EiJ MGP_CASTEiJ_G0029262
protein coding gene Chr5:137391825-137415503 (+)
CBA/J MGP_CBAJ_G0029823
protein coding gene Chr5:149853174-149882144 (+)
DBA/2J MGP_DBA2J_G0029974
protein coding gene Chr5:132993904-133014504 (+)
FVB/NJ MGP_FVBNJ_G0029929
protein coding gene Chr5:132126937-132148127 (+)
LP/J MGP_LPJ_G0030062
protein coding gene Chr5:139478384-139500165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029961
protein coding gene Chr5:152918882-152939903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030630
protein coding gene Chr5:137139736-137160167 (+)
PWK/PhJ MGP_PWKPhJ_G0028977
protein coding gene Chr5:132024525-132046056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028812
protein coding gene Chr5:134717743-134739890 (+)
WSB/EiJ MGP_WSBEiJ_G0029336
protein coding gene Chr5:137890440-137914086 (+)



Homology
more
  • Human Ortholog
    RFC2, replication factor C subunit 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RFC2, replication factor C subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RFC40
  • Links
    NCBI Gene ID: 5982
    neXtProt AC: NX_P35250
    UniProt: P35250

  • Chr Location
    7q11.23; chr7:74231502-74254458 (-)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19718 NCBI Gene Model | MGI Sequence Detail 15639 C57BL/6J ±  kb
transcript NM_020022 RefSeq | MGI Sequence Detail 1518 Not Specified  
polypeptide Q9WUK4 UniProt | EBI | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013906 replication factor C subunit 2
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR003959 ATPase, AAA-type, core
    IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR013748 Replication factor C, C-terminal
Molecular
Reagents
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  • All nucleic 138
    Genomic 3
    cDNA 134
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13826, MGI:1913827, MGI:2140845, MGI:97892
References
more
  • Summaries
    All 43
    Diseases 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:40897 Bunz F, et al., cDNAs encoding the large subunit of human replication factor C. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11014-8
  • Latest
    J:216195 Segura-Puimedon M, et al., Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Hum Mol Genet. 2014 Dec 15;23(24):6481-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory