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Mmp24
Gene Detail
Symbol

Name
ID
Mmp24
matrix metallopeptidase 24
MGI:1341867
Synonyms
Membrane type 5-MMP, MT5-MMP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:155775342-155818366 bp, + strand
From VEGA annotation of GRCm38

  43025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MMP24
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp24

Human
homologs
MMP24, matrix metallopeptidase 24 (membrane-inserted)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10893
neXtProt AC: NX_Q9Y5R2

Human Synonyms: MMP-24, MMP25, MT5MMP, MT5-MMP, MTMMP5, MT-MMP5, MT-MMP 5

Human Chr (Location): 20q11.2; chr20:35226736-35277663 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene fail to develop neuropathic pain after peripheral nerve injury. They also experience reduced stress and enhanced mechanical coordination.
 
Interactions
Mmp24 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell adhesion, cell-cell adhesion, ...
Component extracellular exosome, extracellular matrix, ...
Function cadherin binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (85)    Tissues (27)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 72
Northern blot 1
RT-PCR 12
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MMP24 ; Xenbase mmp24 ; ZFIN mmp24    NEW 
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016131 (Evidence)
Ensembl Gene Model ENSMUSG00000027612 (Evidence)
Entrez Gene 17391 (Evidence)
NIA Mouse Gene Index U002707, U290268
EC 3.4.24.-
Consensus CDS Project CCDS16955.1
International Mouse Phenotyping Consortium Status Mmp24
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016131 VEGA Gene Model | MGI Sequence Detail 43025 C57BL/6J ±  kb
transcript OTTMUST00000038556 VEGA | MGI Sequence Detail 4306 Not Applicable 
polypeptide OTTMUSP00000017259 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(424 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR028723 Matrix metalloproteinase-24
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, stromelysin-type
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010483 matrix metalloproteinase-24
References
(Earliest) J:50709 Pei D, Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem. 1999 Mar 26;274(13):8925-32
(Latest) J:215095 Mao Y, et al., Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear. PLoS One. 2014;9(4):e94580
All references(38)
Other
accession IDs
MGI:2139209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory