Mmp24
Gene Detail

Symbol Name ID

Mmp24 matrix metallopeptidase 24 MGI:1341867

Synonyms

Membrane type 5-MMP, MT5-MMP

Feature Type

protein coding gene

Genetic Map

Chromosome 2

77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:155775342-155818366 bp, + strand From VEGA annotation of GRCm38   43025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21331  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp24

Human homologs

Human Homolog		MMP24, matrix metallopeptidase 24 (membrane-inserted)
NCBI Gene ID		10893
neXtProt AC		NX_Q9Y5R2
Human Synonyms		MMP-24, MMP25, MT5MMP, MT5-MMP, MTMMP5, MT-MMP5, MT-MMP 5
Human Chr (Location)		20q11.2; chr20:33814539-33864804 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for disruptions in this gene fail to develop neuropathic pain after peripheral nerve injury. They also experience reduced stress and enhanced mechanical coordination.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	proteolysis
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (27)    Images (21)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	72
Northern blot	1
RT-PCR	12

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016131 (Evidence)
Ensembl Gene Model	ENSMUSG00000027612 (Evidence)
Entrez Gene	17391 (Evidence)
NIA Mouse Gene Index	U002707, U290268
EC	3.4.24.-
Consensus CDS Project	CCDS16955.1
International Mouse Knockout Project Status	Mmp24

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016131	VEGA Gene Model | MGI Sequence Detail	43025	C57BL/6J
transcript	OTTMUST00000038556	VEGA | MGI Sequence Detail	4306	Not Applicable
polypeptide	OTTMUSP00000017259	VEGA | MGI Sequence Detail	618	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(243 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR021805	Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010483	matrix metalloproteinase-24

References

(Earliest) J:50709 Pei D, Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem. 1999 Mar 26;274(13):8925-32
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Other accession IDs

MGI:2139209