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Mmp24
Gene Detail
 Symbol
Name
ID
Mmp24
matrix metallopeptidase 24
MGI:1341867
Synonyms Membrane type 5-MMP, MT5-MMP
Feature Type protein coding gene
Genetic Map
Chromosome 2
77.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:155775342-155818366 bp, + strand
From VEGA annotation of GRCm38

  43025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp24

Human
homologs
Human Homolog MMP24, matrix metallopeptidase 24 (membrane-inserted)
NCBI Gene ID 10893
neXtProt AC  NX_Q9Y5R2
Human Synonyms  MMP-24, MMP25, MT5MMP, MT5-MMP, MTMMP5, MT-MMP5, MT-MMP 5
Human Chr (Location)  20q11.2; chr20:35226736-35277001 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene fail to develop neuropathic pain after peripheral nerve injury. They also experience reduced stress and enhanced mechanical coordination.
 
Interactions
Mmp24 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process proteolysis
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (85)    Tissues (27)    Images (21)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 72
Northern blot 1
RT-PCR 12
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016131 (Evidence)
Ensembl Gene ModelENSMUSG00000027612 (Evidence)
Entrez Gene17391 (Evidence)
NIA Mouse Gene IndexU002707, U290268
EC3.4.24.-
Consensus CDS ProjectCCDS16955.1
International Mouse Knockout Project StatusMmp24
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016131 VEGA Gene Model | MGI Sequence Detail 43025 C57BL/6J ±  kb
transcript OTTMUST00000038556 VEGA | MGI Sequence Detail 4306 Not Applicable 
polypeptide OTTMUSP00000017259 VEGA | MGI Sequence Detail 618 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(424 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminal
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010483 matrix metalloproteinase-24
References (Earliest) J:50709 Pei D, Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J Biol Chem. 1999 Mar 26;274(13):8925-32
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Other
accession IDs
MGI:2139209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory