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Mark3
Gene Detail
Symbol

Name
ID
Mark3
MAP/microtubule affinity-regulating kinase 3
MGI:1341865
Synonyms
1600015G02Rik, A430080F22Rik, C-TAK1, ETK-1, mKIAA1860
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.05 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:111574510-111656227 bp, + strand
From NCBI annotation of GRCm38

  81718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55653  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mark3

Human
homologs
Human Homolog MARK3, MAP/microtubule affinity-regulating kinase 3
NCBI Gene ID 4140
neXtProt AC  NX_P27448
Human Synonyms  CTAK1, KP78, Par-1a, PAR1A
Human Chr (Location)  14q32.32; chr14:103385364-103503831 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(59) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene results in decreased body weight, increased energy expenditure, reduced adiposity, and protection from high-fat diet induced obesity. On a high-fat diet, mice show resistance to hepatic steatosis, improved glucose tolerance, and decreased insulin levels.
 
Interactions
Mark3 interacts with 186 markers (Mir7-1, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process phosphorylation, protein phosphorylation
Component membrane, plasma membrane
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (20)    Tissues (17)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
Northern blot 10
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000007411 (Evidence)
Entrez Gene17169 (Evidence)
EC2.7.11.1
PDB1V5S, 1UL7
Consensus CDS ProjectCCDS26181.1, CCDS26182.1
International Mouse Knockout Project StatusMark3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17169 NCBI Gene Model | MGI Sequence Detail 81718 C57BL/6J ±  kb
transcript NM_021516 RefSeq | MGI Sequence Detail 3388 C57BL/6 
polypeptide Q03141 UniProt | EBI | MGI Sequence Detail 753 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(28) UniProt(4)
Polymorphisms
SNPs within 2kb(703 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001772 Kinase associated domain 1 (KA1)
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology PR:000010188 MAP/microtubule affinity-regulating kinase 3
Graphical View of Protein Domain Structure
References
(Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:185205 Heisig J, et al., Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012 May;8(5):e1002728
All references(44)
Other
accession IDs
MGI:1913749, MGI:2441800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory