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Gstz1
Gene Detail
 Symbol
Name
ID
Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
MGI:1341859
Synonyms maleylacetoacetate isomerase
Feature Type protein coding gene
Genetic Map
Chromosome 12
41.34 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:87147707-87164721 bp, + strand
From Ensembl annotation of GRCm38

  17015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7747  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gstz1

Human
homologs
Human Homolog GSTZ1, glutathione S-transferase zeta 1
NCBI Gene ID 2954
neXtProt AC  NX_O43708
Human Synonyms  GSTZ1-1, MAAI, MAI
Human Chr (Location)  14q24.3; chr14:77320887-77331597 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have essentially normal phenotypes but do display ketoaciduria and severe sensitivity to diets high in tyrosine or phenylalanine.
 
Interactions
Gstz1 interacts with 109 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process aromatic amino acid family metabolic process, glutathione metabolic process, ...
Component cytoplasm, mitochondrion
Function catalytic activity, glutathione transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (95)    Tissues (95)    Images (13)
Theiler Stages: 22
Assay TypeResults
RNA in situ 95
cDNA source data(130)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(130) cDNA(130)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021033 (Evidence)
Entrez Gene14874 (Evidence)
UniGene29652
DFCITC1575939, TC1593917, TC1656661
NIA Mouse Gene IndexU014225
EC5.2.1.2., 2.5.1.18, 5.2.1.2
PDB2CZ2, 2CZ3
Consensus CDS ProjectCCDS26071.1
International Mouse Knockout Project StatusGstz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021033 Ensembl Gene Model | MGI Sequence Detail 17015 C57BL/6J ±  kb
transcript ENSMUST00000063117 Ensembl | MGI Sequence Detail 1665 Not Applicable 
polypeptide ENSMUSP00000053540 Ensembl | MGI Sequence Detail 216 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR005955 Maleylacetoacetate isomerase
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008307 maleylacetoacetate isomerase
References (Earliest) J:56027 Fernandez-Canon JM, et al., Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase. Genomics. 1999 Jun 15;58(3):263-9
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory