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Trpv2
Gene Detail
Symbol

Name
ID
Trpv2
transient receptor potential cation channel, subfamily V, member 2
MGI:1341836
Synonyms
OTRPC2, Vrl1, VRL-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
38.48 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:62574486-62600515 bp, + strand
From VEGA annotation of GRCm38

  26030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TRPV2
Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv2

Human
homologs
TRPV2, transient receptor potential cation channel, subfamily V, member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51393
neXtProt AC: NX_Q9Y5S1

Human Synonyms: VRL, VRL1, VRL-1

Human Chr (Location): 17p11.2; chr17:16415542-16437003 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.
 
Interactions
Trpv2 interacts with 65 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component axon, axonal growth cone, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (91)    Tissues (21)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 84
RT-PCR 7
cDNA source data(37)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487682    NEW 
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005868 (Evidence)
Ensembl Gene Model ENSMUSG00000018507 (Evidence)
Entrez Gene 22368 (Evidence)
UniGene 288064
DFCI TC1609468, TC1596980, TC1577697
DoTS DT.101706767, DT.101249182, DT.97371308, DT.523351, DT.99858726
NIA Mouse Gene Index U012738
Consensus CDS Project CCDS24827.1
International Mouse Phenotyping Consortium Status Trpv2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005868 VEGA Gene Model | MGI Sequence Detail 26030 C57BL/6J ±  kb
transcript OTTMUST00000013064 VEGA | MGI Sequence Detail 2909 Not Applicable 
polypeptide OTTMUSP00000006068 VEGA | MGI Sequence Detail 756 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
InterPro IPR024865 Transient receptor potential channel, vanilloid 2
Protein Ontology PR:000001064 transient receptor potential cation channel TRPV2
References
(Earliest) J:53008 Kanzaki M, et al., Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1. Nat Cell Biol. 1999;1:165-170
(Latest) J:211511 Shibasaki K, et al., Astrocytes express functional TRPV2 ion channels. Biochem Biophys Res Commun. 2013 Nov 15;441(2):327-32
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory