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Trpv2
Gene Detail
 Symbol
Name
ID
Trpv2
transient receptor potential cation channel, subfamily V, member 2
MGI:1341836
Synonyms OTRPC2, Vrl1, VRL-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
38.48 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:62574486-62600515 bp, + strand
From VEGA annotation of GRCm38

  26030 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv2

Human
homologs
Human Homolog TRPV2, transient receptor potential cation channel, subfamily V, member 2
NCBI Gene ID 51393
neXtProt AC  NX_Q9Y5S1
Human Synonyms  VRL, VRL1, VRL-1
Human Chr (Location)  17p11.2; chr17:16415542-16437003 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired macrophage migration, binding, and phagocytosis with increased susceptiblity and mortality following bacterial infection.
 
Interactions
Trpv2 interacts with 65 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component axon, axonal growth cone, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (91)    Tissues (20)    Images (19)
Theiler Stages: 23, 25, 26, 28
Assay TypeResults
RNA in situ 84
RT-PCR 7
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005868 (Evidence)
Ensembl Gene ModelENSMUSG00000018507 (Evidence)
Entrez Gene22368 (Evidence)
UniGene288064
DFCITC1577697, TC1596980, TC1609468
DoTSDT.101249182, DT.101706767, DT.523351, DT.97371308, DT.99858726
NIA Mouse Gene IndexU012738
Consensus CDS ProjectCCDS24827.1
International Mouse Knockout Project StatusTrpv2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005868 VEGA Gene Model | MGI Sequence Detail 26030 C57BL/6J ±  kb
transcript OTTMUST00000013064 VEGA | MGI Sequence Detail 2909 Not Applicable 
polypeptide OTTMUSP00000006068 VEGA | MGI Sequence Detail 756 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
InterPro IPR024865 Transient receptor potential channel, vanilloid 2
Protein Ontology PR:000001064 transient receptor potential cation channel TRPV2
References (Earliest) J:53008 Kanzaki M, et al., Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-1. Nat Cell Biol. 1999;1:165-170
(Latest) J:194675 Mihara H, et al., TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice. Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G235-40
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory