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Mlf1 Gene Detail
Summary
  • Symbol
    Mlf1
  • Name
    myeloid leukemia factor 1
  • Synonyms
    HLS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341819
    NCBI Gene: 17349
  • Gene Overview
    MyGene.info: MLF1
Location & Maps
more
  • Sequence Map
    Chr3:67374097-67400003 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25907 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.91 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 4291
    neXtProt AC: NX_P58340

  • Chr Location
    3q25.1; chr3:158571163-158606460 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7839
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MLF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mlf1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022658 VEGA Gene Model | MGI Sequence Detail 25907 C57BL/6J ±  kb
transcript OTTMUST00000054285 VEGA | MGI Sequence Detail 1113 Not Applicable  
polypeptide OTTMUSP00000025895 VEGA | MGI Sequence Detail 282 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    116 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000010439 myeloid leukemia factor 1
  • InterPro Domains
    IPR019376 Myeloid leukemia factor
Molecular
Reagents
less
  • All nucleic 68
    cDNA 68

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:56033 Hitzler JK, et al., cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul;155(1):53-9
  • Latest
    J:220288 Choudhury KR, et al., Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity. Biochem Biophys Res Commun. 2015 Jan 2;456(1):66-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory