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Mlf1 Gene Detail
Summary
  • Symbol
    Mlf1
  • Name
    myeloid leukemia factor 1
  • Synonyms
    HLS7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341819
    NCBI Gene: 17349
  • Gene Overview
    MyGene.info: MLF1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:67374097-67400000 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 30.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341819
protein coding gene Chr3:67374097-67400003 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027279
protein coding gene Chr3:66527076-66556804 (+)
A/J MGP_AJ_G0027241
protein coding gene Chr3:64576272-64605675 (+)
AKR/J MGP_AKRJ_G0027209
protein coding gene Chr3:65944575-65973106 (+)
BALB/cJ MGP_BALBcJ_G0027252
protein coding gene Chr3:64437422-64464588 (+)
C3H/HeJ MGP_C3HHeJ_G0026996
protein coding gene Chr3:66202060-66228050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027698
protein coding gene Chr3:69025044-69053735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025051
protein coding gene Chr3:60913434-60939971 (+)
CAST/EiJ MGP_CASTEiJ_G0026443
protein coding gene Chr3:66144556-66175695 (+)
CBA/J MGP_CBAJ_G0026971
protein coding gene Chr3:71161774-71196267 (+)
DBA/2J MGP_DBA2J_G0027107
protein coding gene Chr3:64074827-64103764 (+)
FVB/NJ MGP_FVBNJ_G0027075
protein coding gene Chr3:62712817-62738680 (+)
LP/J MGP_LPJ_G0027215
protein coding gene Chr3:67463510-67492758 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027094
protein coding gene Chr3:75829921-75862260 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027756
protein coding gene Chr3:65838752-65865302 (+)
PWK/PhJ MGP_PWKPhJ_G0026177
protein coding gene Chr3:63825034-63852213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025993
protein coding gene Chr3:64958274-64983963 (+)
WSB/EiJ MGP_WSBEiJ_G0026521
protein coding gene Chr3:65946133-65974745 (+)



Homology
more
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLF1, myeloid leukemia factor 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4291
    neXtProt AC: NX_P58340
    UniProt: P58340

  • Chr Location
    3q25.32; chr3:158571162-158606460 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7839
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MLF1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MLF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Mlf1
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17349 NCBI Gene Model | MGI Sequence Detail 25904 C57BL/6J ±  kb
transcript NM_001039543 RefSeq | MGI Sequence Detail 1178 C57BL/6  
polypeptide Q9QWV4 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR019376 Myeloid leukemia factor
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:56033 Hitzler JK, et al., cDNA cloning, expression pattern, and chromosomal localization of Mlf1, murine homologue of a gene involved in myelodysplasia and acute myeloid leukemia. Am J Pathol. 1999 Jul;155(1):53-9
  • Latest
    J:262096 Johnson JA, et al., Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018 Apr 16;7(4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory