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Cnga3
Gene Detail
Symbol

Name
ID
Cnga3
cyclic nucleotide gated channel alpha 3
MGI:1341818
Synonyms
CNG3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
15.46 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:37219261-37263384 bp, + strand
From NCBI annotation of GRCm38

  44124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated channel, alpha subunit
Gene Tree: Cnga3

Human
homologs
Human Homolog CNGA3, cyclic nucleotide gated channel alpha 3
NCBI Gene ID 1261
neXtProt AC  NX_Q16281
Human Synonyms  ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
Human Chr (Location)  2q11.2; chr2:98346155-98398601 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CNGA3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Spontaneous(1) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous mutant animals experience progressive loss of cone photoreceptor cells.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Cnga3 interacts with 152 markers (Mir7-1, Mir15b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cation transmembrane transport, cation transport, ...
Component cytoplasm, dendrite, ...
Function cGMP binding, intracellular cAMP activated cation channel activity, ...
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000026114 (Evidence)
Entrez Gene12790 (Evidence)
UniGene214224
DFCITC1587647, TC1656354
DoTSDT.110892431, DT.91573107
Consensus CDS ProjectCCDS14890.1
International Mouse Knockout Project StatusCnga3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12790 NCBI Gene Model | MGI Sequence Detail 44124 C57BL/6J ±  kb
transcript NM_001282010 RefSeq | MGI Sequence Detail 3623 C57BL/6 
polypeptide Q9JJZ8 UniProt | EBI | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000696 cyclic nucleotide-gated cation channel alpha-3
Graphical View of Protein Domain Structure
References
(Earliest) J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
(Latest) J:202332 Xu J, et al., cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. J Neurosci. 2013 Sep 11;33(37):14939-48
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory