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Cnga3
Gene Detail
 Symbol
Name
ID
Cnga3
cyclic nucleotide gated channel alpha 3
MGI:1341818
Synonyms CNG3
Feature Type protein coding gene
Genetic Map
Chromosome 1
15.46 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:37218336-37263384 bp, + strand
From VEGA annotation of GRCm38

  45049 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated channel, alpha subunit
Gene Tree: Cnga3

Human
homologs
Human Homolog CNGA3, cyclic nucleotide gated channel alpha 3
NCBI Gene ID 1261
neXtProt AC  NX_Q16281
Human Synonyms  ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
Human Chr (Location)  2q11.2; chr2:98346155-98398601 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CNGA3
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(1) Spontaneous(1)
 
Homozygous mutant animals experience progressive loss of cone photoreceptor cells.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process cation transport, ion transmembrane transport, ...
Component cytoplasm, dendrite, ...
Function cGMP binding, intracellular cAMP activated cation channel activity, ...
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000024612 (Evidence)
Ensembl Gene ModelENSMUSG00000026114 (Evidence)
Entrez Gene12790 (Evidence)
UniGene214224
DFCITC1587647, TC1656354
DoTSDT.110892431, DT.91573107
Consensus CDS ProjectCCDS14890.1
International Mouse Knockout Project StatusCnga3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024612 VEGA Gene Model | MGI Sequence Detail 45049 C57BL/6J ±  kb
transcript OTTMUST00000060500 VEGA | MGI Sequence Detail 3497 Not Applicable 
polypeptide OTTMUSP00000029513 VEGA | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(462 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000696 cyclic nucleotide-gated cation channel alpha-3
References (Earliest) J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
(Latest) J:202332 Xu J, et al., cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. J Neurosci. 2013 Sep 11;33(37):14939-48
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory