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Cnga3
Gene Detail
Symbol

Name
ID
Cnga3
cyclic nucleotide gated channel alpha 3
MGI:1341818
Synonyms
CNG3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
15.46 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:37214434-37263384 bp, + strand
From VEGA annotation of GRCm38

  48951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CNGA3
Protein SuperFamily: cyclic nucleotide-gated channel, alpha subunit
Gene Tree: Cnga3

Human
homologs
CNGA3, cyclic nucleotide gated channel alpha 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1261
neXtProt AC: NX_Q16281

Human Synonyms: ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3

Human Chr (Location): 2q11.2; chr2:98346155-98399154 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CNGA3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Spontaneous(1) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutant animals experience progressive loss of cone photoreceptor cells.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Cnga3 interacts with 152 markers (Mir7-1, Mir15b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cation transmembrane transport, cation transport, ...
Component cytoplasm, dendrite, ...
Function cGMP binding, intracellular cAMP activated cation channel activity, ...
External Resources: FuncBase
Expression
cDNA source data(1)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase cnga3    NEW 
Molecular
reagents
All nucleic(1) cDNA(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024612 (Evidence)
Ensembl Gene Model ENSMUSG00000026114 (Evidence)
Entrez Gene 12790 (Evidence)
UniGene 214224
DFCI TC1656354, TC1587647
DoTS DT.110892431, DT.91573107
Consensus CDS Project CCDS14890.1
International Mouse Phenotyping Consortium Status Cnga3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024612 VEGA Gene Model | MGI Sequence Detail 48951 C57BL/6J ±  kb
transcript OTTMUST00000126151 VEGA | MGI Sequence Detail 2197 Not Applicable 
polypeptide OTTMUSP00000068272 VEGA | MGI Sequence Detail 669 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000696 cyclic nucleotide-gated cation channel alpha-3
References
(Earliest) J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
(Latest) J:219606 Tikidji-Hamburyan A, et al., Retinal output changes qualitatively with every change in ambient illuminance. Nat Neurosci. 2015 Jan;18(1):66-74
All references(64)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory