Cnga3
Gene Detail

Symbol Name ID

Cnga3 cyclic nucleotide gated channel alpha 3 MGI:1341818

Synonyms

CNG3

Feature Type

protein coding gene

Genetic Map

Chromosome 1

15.46 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:37218336-37263384 bp, + strand From VEGA annotation of GRCm38   45049 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated channel, alpha subunit
Gene Tree: Cnga3

Human homologs

Human Homolog		CNGA3, cyclic nucleotide gated channel alpha 3
NCBI Gene ID		1261
neXtProt AC		NX_Q16281
Human Synonyms		ACHM2, CCNC1, CCNCa, CCNCalpha, CNCG3, CNG3
Human Chr (Location)		2q11.2; chr2:98962618-99015064 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CNGA3

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Spontaneous(1)
 

Homozygous mutant animals experience progressive loss of cone photoreceptor cells.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cation transport, ion transmembrane transport, ...
Component	cytoplasm, dendrite, ...
Function	cGMP binding, intracellular cGMP activated cation channel activity, ...

External Resources: FuncBase

Expression

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(1) cDNA(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000024612 (Evidence)
Ensembl Gene Model	ENSMUSG00000026114 (Evidence)
Entrez Gene	12790 (Evidence)
UniGene	214224
DFCI	TC1587647
DoTS	DT.91573107
Consensus CDS Project	CCDS14890.1
International Mouse Knockout Project Status	Cnga3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024612	VEGA Gene Model | MGI Sequence Detail	45049	C57BL/6J
transcript	OTTMUST00000060500	VEGA | MGI Sequence Detail	3497	Not Applicable
polypeptide	OTTMUSP00000029513	VEGA | MGI Sequence Detail	631	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(229 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000696	cyclic nucleotide-gated cation channel alpha-3

References

(Earliest) J:56020 Biel M, et al., Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7553-7
(Latest) J:187090 Pang JJ, et al., AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia. PLoS One. 2012;7(4):e35250
All references(55)