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Lgr5 Gene Detail
Summary
  • Symbol
    Lgr5
  • Name
    leucine rich repeat containing G protein coupled receptor 5
  • Synonyms
    Gpr49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341817
    NCBI Gene: 14160
  • Gene Overview
    MyGene.info: LGR5
Location & Maps
more
  • Sequence Map
    Chr10:115450311-115587780 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      137470 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 63.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LGR5, leucine rich repeat containing G protein-coupled receptor 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LGR5, leucine rich repeat containing G protein-coupled receptor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FEX, GPR49, GPR67, GRP49, HG38
  • Links
    NCBI Gene ID: 8549
    neXtProt AC: NX_O75473

  • Chr Location
    12q21.1; chr12:71439162-71586310 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Lgr5 mouse models

Human Disease Mouse Models
       Ankyloglossia   OMIM: 106280 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 5 genetic backgrounds
    36 phenotypes from multigenic genotypes
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Lgr5
  • Incidental Mutations
Mice homozygous for a knock-out allele display 100% neonatal lethality associated with ankyloglossia, gastrointestinal distension, cyanosis and respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020836 VEGA Gene Model | MGI Sequence Detail 137470 C57BL/6J ±  kb
transcript OTTMUST00000049259 VEGA | MGI Sequence Detail 4714 Not Applicable  
polypeptide OTTMUSP00000022795 VEGA | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1356 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001592 leucine-rich repeat-containing G-protein coupled receptor 5
  • InterPro Domains
    IPR002131 Glycoprotein hormone receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 20
    cDNA 16
    Primer pair 3
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 219
    Developmental Gene Expression 33
    Diseases 1
    Gene Ontology 8
    Phenotypes 174
  • Earliest
    J:51995 Hermey G, et al., Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem Biophys Res Commun. 1999 Jan 8;254(1):273-9
  • Latest
    J:231673 Gustin SE, et al., WNT/beta-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary. Dev Biol. 2016 Apr 15;412(2):250-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory