Lgr5
Gene Detail

Symbol Name ID

Lgr5 leucine rich repeat containing G protein coupled receptor 5 MGI:1341817

Synonyms

Gpr49

Feature Type

protein coding gene

Genetic Map

Chromosome 10

63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:115450311-115587780 bp, - strand From VEGA annotation of GRCm38   137470 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr5

Human homologs

Human Homolog		LGR5, leucine-rich repeat containing G protein-coupled receptor 5
NCBI Gene ID		8549
neXtProt AC		NX_O75473
Human Synonyms		FEX, GPR49, GPR67, GRP49, HG38
Human Chr (Location)		12q22-q23; chr12:71833813-71978622 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a knock-out allele display 100% neonatal lethality associated with ankyloglossia, gastrointestinal distension, cyanosis and respiratory failure.

 
Human Diseases Modeled Using Mouse Lgr5 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	G-protein coupled receptor signaling pathway, inner ear development, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, protein-hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (185)    Tissues (126)    Images (53)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	120
In situ reporter (knock in)	45
RT-PCR	20

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000020836 (Evidence)
Ensembl Gene Model	ENSMUSG00000020140 (Evidence)
Entrez Gene	14160 (Evidence)
UniGene	42103
DFCI	TC1599407, TC1628793, TC1654057
DoTS	DT.110613888, DT.40184645, DT.55259024, DT.91438732
NIA Mouse Gene Index	U032237
Consensus CDS Project	CCDS24180.1
International Mouse Knockout Project Status	Lgr5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020836	VEGA Gene Model | MGI Sequence Detail	137470	C57BL/6J
transcript	OTTMUST00000049259	VEGA | MGI Sequence Detail	4714	Not Applicable
polypeptide	OTTMUSP00000022795	VEGA | MGI Sequence Detail	907	Not Applicable

All sequences(48) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(518 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000001592	leucine-rich repeat-containing G-protein coupled receptor 5

References

(Earliest) J:51995 Hermey G, et al., Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem Biophys Res Commun. 1999 Jan 8;254(1):273-9
(Latest) J:194551 Huch M, et al., In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 2013 Feb 14;494(7436):247-50
All references(98)