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Lgr5
Gene Detail
 Symbol
Name
ID
Lgr5
leucine rich repeat containing G protein coupled receptor 5
MGI:1341817
Synonyms Gpr49
Feature Type protein coding gene
Genetic Map
Chromosome 10
63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:115450311-115587780 bp, - strand
From VEGA annotation of GRCm38

  137470 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20807  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr5

Human
homologs
Human Homolog LGR5, leucine-rich repeat containing G protein-coupled receptor 5
NCBI Gene ID 8549
neXtProt AC  NX_O75473
Human Synonyms  FEX, GPR49, GPR67, GRP49, HG38
Human Chr (Location)  12q22-q23; chr12:71439154-71586310 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display 100% neonatal lethality associated with ankyloglossia, gastrointestinal distension, cyanosis and respiratory failure.
 
Human Diseases Modeled Using Mouse Lgr5 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process G-protein coupled receptor signaling pathway, inner ear development, ...
Component Golgi apparatus, integral component of membrane, ...
Function G-protein coupled receptor activity, protein-hormone receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (185)    Tissues (126)    Images (53)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 120
In situ reporter (knock in) 45
RT-PCR 20
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020836 (Evidence)
Ensembl Gene ModelENSMUSG00000020140 (Evidence)
Entrez Gene14160 (Evidence)
UniGene42103
DFCITC1599407, TC1628793, TC1654057
DoTSDT.110613888, DT.40184645, DT.55259024, DT.91438732
NIA Mouse Gene IndexU032237
Consensus CDS ProjectCCDS24180.1
International Mouse Knockout Project StatusLgr5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020836 VEGA Gene Model | MGI Sequence Detail 137470 C57BL/6J ±  kb
transcript OTTMUST00000049259 VEGA | MGI Sequence Detail 4714 Not Applicable 
polypeptide OTTMUSP00000022795 VEGA | MGI Sequence Detail 907 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(1362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR025875 Leucine rich repeat 4
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000001592 leucine-rich repeat-containing G-protein coupled receptor 5
References (Earliest) J:51995 Hermey G, et al., Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse. Biochem Biophys Res Commun. 1999 Jan 8;254(1):273-9
(Latest) J:210379 Sukhdeo K, et al., The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb;119:106-10
All references(143)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory