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Pla2g2d Gene Detail
Summary
  • Symbol
    Pla2g2d
  • Name
    phospholipase A2, group IID
  • Synonyms
    mGIID, Splash
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341796
    NCBI Gene: 18782
  • Gene Overview
    MyGene.info: PLA2G2D
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138775735-138782046 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341796
protein coding gene Chr4:138775735-138782143 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029003
protein coding gene Chr4:141560535-141568075 (+)
A/J MGP_AJ_G0028962
protein coding gene Chr4:135484157-135491187 (+)
AKR/J MGP_AKRJ_G0028914
protein coding gene Chr4:139362422-139368710 (+)
BALB/cJ MGP_BALBcJ_G0028986
protein coding gene Chr4:136160127-136166825 (+)
C3H/HeJ MGP_C3HHeJ_G0028700
protein coding gene Chr4:139735061-139741336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029427
protein coding gene Chr4:146562441-146568783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026698
protein coding gene Chr4:128465299-128471576 (+)
CAST/EiJ MGP_CASTEiJ_G0028132
protein coding gene Chr4:137905547-137910909 (+)
CBA/J MGP_CBAJ_G0028665
protein coding gene Chr4:150786257-150792545 (+)
DBA/2J MGP_DBA2J_G0028814
protein coding gene Chr4:135867004-135873293 (+)
FVB/NJ MGP_FVBNJ_G0028781
protein coding gene Chr4:134895194-134902062 (+)
LP/J MGP_LPJ_G0028913
protein coding gene Chr4:141636019-141643930 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028807
protein coding gene Chr4:154745836-154752199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029465
protein coding gene Chr4:139894745-139901062 (+)
PWK/PhJ MGP_PWKPhJ_G0027853
protein coding gene Chr4:132724972-132730327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027678
protein coding gene Chr4:135645592-135651938 (+)
WSB/EiJ MGP_WSBEiJ_G0028210
protein coding gene Chr4:140130705-140136991 (+)



Homology
more
  • Human Ortholog
    PLA2G2D, phospholipase A2 group IID
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PLA2G2D, phospholipase A2 group IID
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PLA2IID, sPLA2-IID, sPLA2S, SPLASH
  • Links
    NCBI Gene ID: 26279
    neXtProt AC: NX_Q9UNK4
    UniProt: Q9UNK4

  • Chr Location
    1p36.12; chr1:20112650-20119566 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired resolution of hapten-induced contact hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041202 Ensembl Gene Model | MGI Sequence Detail 6312 C57BL/6J ±  kb
transcript ENSMUST00000030528 Ensembl | MGI Sequence Detail 2167 Not Applicable  
polypeptide ENSMUSP00000030528 Ensembl | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 26
    Primer pair 2
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:56018 Valentin E, et al., Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. J Biol Chem. 1999 Jul 2;274(27):19152-60
  • Latest
    J:235448 Miki Y, et al., Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer. J Biol Chem. 2016 Jul 22;291(30):15588-601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory