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Pbx2
Gene Detail
 Symbol
Name
ID
Pbx2
pre B cell leukemia homeobox 2
MGI:1341793
Synonyms G17
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:34591266-34597400 bp, + strand
From VEGA annotation of GRCm38

  6135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Pbx2

Human
homologs
Human Homolog PBX2, pre-B-cell leukemia homeobox 2
NCBI Gene ID 5089
neXtProt AC  NX_P40425
Human Synonyms  G17, HOX12, PBX2MHC
Human Chr (Location)  6p21.3; chr6:32184733-32190186 (-)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Homozygous null mice are healthy and fertile with no apparent abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process embryonic limb morphogenesis, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus, transcription factor complex
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (110)    Tissues (103)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 89
Western blot 4
RT-PCR 15
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(72) Genomic(1) cDNA(70) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037073 (Evidence)
Ensembl Gene ModelENSMUSG00000034673 (Evidence)
Entrez Gene18515 (Evidence)
UniGene390957
DFCITC1577544
NIA Mouse Gene IndexU017859
Consensus CDS ProjectCCDS28648.1
International Mouse Knockout Project StatusPbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037073 VEGA Gene Model | MGI Sequence Detail 6135 C57BL/6J ±  kb
transcript OTTMUST00000095381 VEGA | MGI Sequence Detail 3068 Not Applicable 
polypeptide OTTMUSP00000053228 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(9)
Polymorphisms SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR005542 PBX
Protein Ontology PR:000012327 pre-B-cell leukemia transcription factor 2
References (Earliest) J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
(Latest) J:197449 Coles GL, et al., Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
All references(63)
Other
accession IDs
MGI:2147002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory