Pbx2
Gene Detail

Symbol Name ID

Pbx2 pre B cell leukemia homeobox 2 MGI:1341793

Synonyms

G17

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:34591266-34597400 bp, + strand From VEGA annotation of GRCm38   6135 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Pbx2

Human homologs

Human Homolog		PBX2, pre-B-cell leukemia homeobox 2
NCBI Gene ID		5089
neXtProt AC		NX_P40425
Human Synonyms		G17, HOX12, PBX2MHC
Human Chr (Location)		6p21.3; chr6:32152510-32157963 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous null mice are healthy and fertile with no apparent abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	embryonic limb morphogenesis, positive regulation of transcription from RNA polymerase II promoter, ...
Component	nucleus, transcription factor complex
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (109)    Tissues (102)    Images (23)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	88
Western blot	4
RT-PCR	15

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(70) Genomic(1) cDNA(68) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037073 (Evidence)
Ensembl Gene Model	ENSMUSG00000034673 (Evidence)
Entrez Gene	18515 (Evidence)
UniGene	390957
DFCI	TC1577544
NIA Mouse Gene Index	U017859
Consensus CDS Project	CCDS28648.1
International Mouse Knockout Project Status	Pbx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037073	VEGA Gene Model | MGI Sequence Detail	6135	C57BL/6J
transcript	OTTMUST00000095381	VEGA | MGI Sequence Detail	3068	Not Applicable
polypeptide	OTTMUSP00000053228	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(40) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR005542	PBX
Protein Ontology	PR:000012327	pre-B-cell leukemia transcription factor 2

References

(Earliest) J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
(Latest) J:185964 Sgado P, et al., The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24
All references(62)

Other accession IDs

MGI:2147002