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Pbx2 Gene Detail
Summary
  • Symbol
    Pbx2
  • Name
    pre B cell leukemia homeobox 2
  • Synonyms
    G17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341793
    NCBI Gene: 18515
  • Gene Overview
    MyGene.info: PBX2
Location & Maps
more
  • Sequence Map
    Chr17:34591266-34597400 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6135 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.17 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PBX2, PBX homeobox 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PBX2, PBX homeobox 2
    Orthology source: HomoloGene
  • Synonyms
    G17, HOX12, PBX2MHC
  • Links
    NCBI Gene ID: 5089
    neXtProt AC: NX_P40425

  • Chr Location
    6p21.3; chr6:32184733-32190186 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    18 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Homozygous null mice are healthy and fertile with no apparent abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037073 VEGA Gene Model | MGI Sequence Detail 6135 C57BL/6J ±  kb
transcript OTTMUST00000095381 VEGA | MGI Sequence Detail 3068 Not Applicable  
polypeptide OTTMUSP00000053228 VEGA | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 74
    Genomic 1
    cDNA 70
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:2147002
References
more
  • Summaries
    All 63
    Developmental Gene Expression 31
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
  • Latest
    J:228726 Golonzhka O, et al., Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. Neuron. 2015 Dec 16;88(6):1192-207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory