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Pbx2
Gene Detail
Symbol

Name
ID
Pbx2
pre B cell leukemia homeobox 2
MGI:1341793
Synonyms
G17
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:34591266-34597400 bp, + strand
From VEGA annotation of GRCm38

  6135 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Pbx2

Human
homologs
Human Homolog PBX2, pre-B-cell leukemia homeobox 2
NCBI Gene ID 5089
neXtProt AC  NX_P40425
Human Synonyms  G17, HOX12, PBX2MHC
Human Chr (Location)  6p21.3; chr6:32184733-32190186 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mice are healthy and fertile with no apparent abnormalities.
 
Interactions
Pbx2 interacts with 193 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (30 records)
Data Summary: Results (103)    Tissues (101)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 89
Western blot 4
RT-PCR 8
cDNA source data(69)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) Genomic(1) cDNA(70) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037073 (Evidence)
Ensembl Gene ModelENSMUSG00000034673 (Evidence)
Entrez Gene18515 (Evidence)
UniGene390957
DFCITC1577544
NIA Mouse Gene IndexU017859
Consensus CDS ProjectCCDS28648.1
International Mouse Knockout Project StatusPbx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037073 VEGA Gene Model | MGI Sequence Detail 6135 C57BL/6J ±  kb
transcript OTTMUST00000095381 VEGA | MGI Sequence Detail 3068 Not Applicable 
polypeptide OTTMUSP00000053228 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(17)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR005542 PBX
Protein Ontology PR:000012327 pre-B-cell leukemia transcription factor 2
References
(Earliest) J:2599 Monica K, et al., PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Mol Cell Biol. 1991 Dec;11(12):6149-57
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(64)
Other
accession IDs
MGI:2147002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory