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Trpv1
Gene Detail
 Symbol
Name
ID
Trpv1
transient receptor potential cation channel, subfamily V, member 1
MGI:1341787
Synonyms capsaicin receptor, OTRPC1, Vr1, VR-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.25 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:73234292-73261242 bp, + strand
From VEGA annotation of GRCm38

  26951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12920  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv1

Human
homologs
Human Homolog TRPV1, transient receptor potential cation channel, subfamily V, member 1
NCBI Gene ID 7442
neXtProt AC  NX_Q8NER1
Human Synonyms  VR1
Human Chr (Location)  17p13.2; chr17:3565446-3609411 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice demonstrate abnormal nociception, abnormal anxiety- and conditioning-related behaviors, increased sensitivity to DOCA-salt-induced renal damage, resistance to diet-induced obesity, altered taste sensitivity, and impaired febrile response.
 
Interactions
Trpv1 interacts with 83 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process behavioral response to pain, calcium ion transmembrane transport, ...
Component cell junction, cell projection, ...
Function ATP binding, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (64)    Tissues (36)    Images (27)
Theiler Stages: 19, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 1
RNA in situ 56
RT-PCR 7
cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(3) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006125 (Evidence)
Ensembl Gene ModelENSMUSG00000005952 (Evidence)
Entrez Gene193034 (Evidence)
UniGene447485
DFCITC1590566, TC1624952
DoTSDT.103553227, DT.91359275, DT.94258570
NIA Mouse Gene IndexU012899
Consensus CDS ProjectCCDS25003.1
International Mouse Knockout Project StatusTrpv1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006125 VEGA Gene Model | MGI Sequence Detail 26951 C57BL/6J ±  kb
transcript OTTMUST00000013851 VEGA | MGI Sequence Detail 3361 Not Applicable 
polypeptide OTTMUSP00000006426 VEGA | MGI Sequence Detail 839 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(212 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR024863 Transient receptor potential channel, vanilloid 1
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
Protein Ontology PR:000001065 transient receptor potential cation channel TRPV1
References (Earliest) J:56292 Ma Q, et al., Neurogenin1 and neurogenin2 control two distinct waves of neurogenesis in developing dorsal root ganglia. Genes Dev. 1999 Jul 1;13(13):1717-28
(Latest) J:211334 Wang M, et al., Synaptic modifications in the medial prefrontal cortex in susceptibility and resilience to stress. J Neurosci. 2014 May 28;34(22):7485-92
All references(226)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory