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Kcnh3
Gene Detail
 Symbol
Name
ID
Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
MGI:1341723
Synonyms C030044P22Rik, Elk2, ether a go-go like, Melk2
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.08 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:99224976-99242817 bp, + strand
From NCBI annotation of GRCm38

  17842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32150  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: potassium voltage-gated channel, subfamily H
Gene Tree: Kcnh3

Human
homologs
Human Homolog KCNH3, potassium voltage-gated channel, subfamily H (eag-related), member 3
NCBI Gene ID 23416
neXtProt AC  NX_Q9ULD8
Human Synonyms  BEC1, ELK2, Kv12.2
Human Chr (Location)  12q13; chr12:49539052-49558308 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Radiation induced(1) Targeted(7)
Genomic Mutations involving Kcnh3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal long term object recognition memory, spatial reference memory, spatial working memory, and long term potentiation. Mice homozygous for a different knock-out allele exhibit neuron hyperexcitability and seizures.
 
Interactions
Kcnh3 interacts with 72 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ion transport, phosphorelay signal transduction system, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ion channel activity, phosphorelay sensor kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (3)    Images (2)
Theiler Stages: 25, 28
Assay TypeResults
Western blot 6
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000037579 (Evidence)
Entrez Gene16512 (Evidence)
UniGene374793
DFCITC1591929, TC1612155
DoTSDT.101343906, DT.40154721, DT.87035981
NIA Mouse Gene IndexU115611
Consensus CDS ProjectCCDS27817.1
International Mouse Knockout Project StatusKcnh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16512 NCBI Gene Model | MGI Sequence Detail 17842 C57BL/6J ±  kb
transcript NM_010601 RefSeq | MGI Sequence Detail 3583 C57BL/6 
polypeptide Q9WVJ0 UniProt | EBI | MGI Sequence Detail 1087 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR001610 PAC motif
InterPro IPR000700 PAS-associated, C-terminal
InterPro IPR000014 PAS domain
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR003950 Potassium channel, voltage-dependent, ELK
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000792 voltage-gated potassium channel KCNH3
Graphical View of Protein Domain Structure
References (Earliest) J:54018 Trudeau MC, et al., Functional analysis of a mouse brain Elk-type K+ channel. J Neurosci. 1999 Apr 15;19(8):2906-18
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Other
accession IDs
MGI:1924786, MGI:2146131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory