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Scnm1 Gene Detail
Summary
  • Symbol
    Scnm1
  • Name
    sodium channel modifier 1
  • Synonyms
    3110001I17Rik, Scnm1-ps
Location & Maps
more
  • Sequence Map
    Chr3:95129536-95134011 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4476 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM, cytoband F2
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    SCNM1, sodium channel modifier 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SCNM1, sodium channel modifier 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79005
    neXtProt AC: NX_Q9BWG6

  • Chr Location
    1q21.3; chr1:151166022-151170297 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11431
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SCNM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Scnm1
  • Incidental Mutations
    APF , CvDC
The Scnm1 locus influences the severity of the Scn8amed-J phenotype. Mice carrying the recesive susceptibility allele of the modifier are paralyzed and do not survive beyond 1 month. Mice carryimg the resistant allele display progressive dystonia with ataxia and live more than 1.5 years.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022306 VEGA Gene Model | MGI Sequence Detail 4476 C57BL/6J ±  kb
transcript OTTMUST00000047010 VEGA | MGI Sequence Detail 1054 Not Applicable  
polypeptide OTTMUSP00000045978 VEGA | MGI Sequence Detail 186 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    51 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 72

    Microarray probesets 3
Other
Accession IDs
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MGI:1916519
References
more
  • Summaries
    All 32
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:53340 Sprunger LK, et al., Dystonia associated with mutation of the neuronal sodium channel Scn8a and identification of the modifier locus Scnm1 on mouse chromosome 3. Hum Mol Genet. 1999 Mar;8(3):471-9
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory