Col14a1 MGI Mouse Gene Detail - MGI:1341272 - collagen, type XIV, alpha 1

Symbol

Col14a1
Name

collagen, type XIV, alpha 1
Synonyms

5730412L22Rik

Feature Type

protein coding gene
IDs

MGI:1341272
NCBI Gene: 12818
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:55171146-55384199 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 21.96 cM, cytoband D
Mapping Data

4 experiments

SNPs within 2kb

1414 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341272	protein coding gene	Chr15:55171040-55384199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021855	protein coding gene	Chr15:54392953-54609388 (+)
A/J	MGP_AJ_G0021815	protein coding gene	Chr15:52242771-52453147 (+)
AKR/J	MGP_AKRJ_G0021796	protein coding gene	Chr15:53732227-53944111 (+)
BALB/cJ	MGP_BALBcJ_G0021822	protein coding gene	Chr15:52460807-52671672 (+)
C3H/HeJ	MGP_C3HHeJ_G0021596	protein coding gene	Chr15:53806055-54019537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022261	protein coding gene	Chr15:56500853-56732188 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019798	protein coding gene	Chr15:49469509-49678739 (+)
CAST/EiJ	MGP_CASTEiJ_G0021113	protein coding gene	Chr15:54397806-54623486 (+)
CBA/J	MGP_CBAJ_G0021565	protein coding gene	Chr15:58483182-58711047 (+)
DBA/2J	MGP_DBA2J_G0021689	protein coding gene	Chr15:52128926-52338153 (+)
FVB/NJ	MGP_FVBNJ_G0021667	protein coding gene	Chr15:51256997-51464975 (+)
LP/J	MGP_LPJ_G0021759	protein coding gene	Chr15:54191932-54408763 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021691	protein coding gene	Chr15:63588580-63810132 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022284	protein coding gene	Chr15:54083845-54305385 (+)
PWK/PhJ	MGP_PWKPhJ_G0020858	protein coding gene	Chr15:52203268-52418356 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020695	protein coding gene	Chr15:53811601-54028192 (+)
WSB/EiJ	MGP_WSBEiJ_G0021168	protein coding gene	Chr15:54045386-54261130 (+)

Human Ortholog

COL14A1, collagen type XIV alpha 1 chain

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COL14A1, collagen type XIV alpha 1 chain
Synonyms

UND
Links

HGNC:2191

NCBI Gene ID: 7373

neXtProt AC: NX_Q05707

UniProt: Q05707
Chr Location

8q24.12; chr8:120059780-120373573 (+) GRCh38

MGI Vertebrate Homology

Col14a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: COL14A1
Gene Tree

Col14a1

Diseases

1 with human COL14A1 associations

				Human Disease	Mouse Models
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

3
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Col14a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display abnormal tendon morphology and abnormal biomechanical properties of the skin and tendons.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

946
Tissues

93
cDNA Data

61
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA COL14A1

Xenbase col14a1

ZFIN col14a1a, col14a1b

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All Sequences

54
RefSeq

8
UniProt

4
CCDS

CCDS37076.1, CCDS88765.1

Ensembl

ENSMUSG00000022371 (Evidence)
NCBI Gene

12818

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022371	Ensembl Gene Model \| MGI Sequence Detail	213054	C57BL/6J	± kb
transcript	ENSMUST00000023053	Ensembl \| MGI Sequence Detail	6457	Not Applicable
polypeptide	ENSMUSP00000023053	Ensembl \| MGI Sequence Detail	1797	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005698 collagen alpha-1(XIV) chain

(term hierarchy)
InterPro Domains

IPR008160 Collagen triple helix repeat

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR048287 Thrombospondin-like, N-terminal domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A

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All nucleic 70

cDNA 62

Primer pair 6

Other 2

Microarray probesets 6

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MGI:1917736, MGI:2146190

Summaries

All 72

Developmental Gene Expression 27

Diseases 1

Gene Ontology 6

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539

TSS for Col14a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131297	Chr15:55171139-55171158 (+)	3 bp
Tssr131298	Chr15:55171194-55171201 (+)	52 bp
Tssr131299	Chr15:55171254-55171257 (+)	110 bp
Tssr131300	Chr15:55321116-55321138 (+)	149,981 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23