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Camk2d Gene Detail
Summary
  • Symbol
    Camk2d
  • Name
    calcium/calmodulin-dependent protein kinase II, delta
  • Synonyms
    2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341265
    NCBI Gene: 108058
  • Gene Overview
    MyGene.info: CAMK2D
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:126596302-126846326 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      250025 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 55.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CAMK2D, calcium/calmodulin dependent protein kinase II delta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAMK2D, calcium/calmodulin dependent protein kinase II delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMKD
  • Links
    NCBI Gene ID: 817
    neXtProt AC: NX_Q13557
    UniProt: Q13557

  • Chr Location
    4q26; chr4:113451032-113761927 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress. Mice homozygous for an allele that produces an oxidant-resistant product exhibit reduced response to myocardial infarction in a diabetic model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023550 VEGA Gene Model | MGI Sequence Detail 250025 C57BL/6J ±  kb
    transcript OTTMUST00000131936 VEGA | MGI Sequence Detail 5396 Not Applicable  
    polypeptide OTTMUSP00000070442 VEGA | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2791 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923610, MGI:1924420
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 13
      Phenotypes 29
    • Earliest
      J:73501 Bauch A, et al., Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta. Eur J Immunol. 1998 Jul;28(7):2167-77
    • Latest
      J:259432 Neef S, et al., Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor. J Mol Cell Cardiol. 2018 Feb;115:73-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/19/2018
    MGI 6.12
    The Jackson Laboratory