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Camk2d Gene Detail
Summary
  • Symbol
    Camk2d
  • Name
    calcium/calmodulin-dependent protein kinase II, delta
  • Synonyms
    2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341265
    NCBI Gene: 108058
  • Gene Overview
    MyGene.info: CAMK2D
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:126596354-126846326 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 55.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2791 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341265
protein coding gene Chr3:126596302-126846326 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027858
protein coding gene Chr3:129021008-129276134 (+)
A/J MGP_AJ_G0027817
protein coding gene Chr3:124625318-124879171 (+)
AKR/J MGP_AKRJ_G0027782
protein coding gene Chr3:127844957-128100732 (+)
BALB/cJ MGP_BALBcJ_G0027829
protein coding gene Chr3:124482320-124731061 (+)
C3H/HeJ MGP_C3HHeJ_G0027559
protein coding gene Chr3:128223513-128481550 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028274
protein coding gene Chr3:133701460-133962472 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025611
protein coding gene Chr3:119880835-120147415 (+)
CAST/EiJ MGP_CASTEiJ_G0027015
protein coding gene Chr3:127729731-127988732 (+)
CBA/J MGP_CBAJ_G0027534
protein coding gene Chr3:138166841-138444915 (+)
DBA/2J MGP_DBA2J_G0027675
protein coding gene Chr3:123852295-124100958 (+)
FVB/NJ MGP_FVBNJ_G0027643
protein coding gene Chr3:121420667-121669349 (+)
LP/J MGP_LPJ_G0027785
protein coding gene Chr3:130565823-130837435 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027673
protein coding gene Chr3:146160646-146444949 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028330
protein coding gene Chr3:127484266-127737495 (+)
PWK/PhJ MGP_PWKPhJ_G0026740
protein coding gene Chr3:123559921-123814187 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026564
protein coding gene Chr3:125549583-125819604 (+)
WSB/EiJ MGP_WSBEiJ_G0027094
protein coding gene Chr3:128186091-128456198 (+)



Homology
more
  • Human Ortholog
    CAMK2D, calcium/calmodulin dependent protein kinase II delta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CAMK2D, calcium/calmodulin dependent protein kinase II delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMKD
  • Links
    NCBI Gene ID: 817
    neXtProt AC: NX_Q13557
    UniProt: Q13557

  • Chr Location
    4q26; chr4:113451032-113761927 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress. Mice homozygous for an allele that produces an oxidant-resistant product exhibit reduced response to myocardial infarction in a diabetic model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108058 NCBI Gene Model | MGI Sequence Detail 249973 C57BL/6J ±  kb
    transcript NM_001346635 RefSeq | MGI Sequence Detail 5682 C57BL/6  
    polypeptide Q6PHZ2 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000003201 calcium/calmodulin-dependent protein kinase type II subunit delta
    • PDB
    • EC
    • InterPro Domains
      IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain
      IPR039071 Calcium/calmodulin-dependent protein kinase type II
      IPR032710 NTF2-like domain superfamily
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
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    • All nucleic 28
      cDNA 28

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923610, MGI:1924420
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 16
      Phenotypes 29
    • Earliest
      J:73501 Bauch A, et al., Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta. Eur J Immunol. 1998 Jul;28(7):2167-77
    • Latest
      J:259432 Neef S, et al., Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor. J Mol Cell Cardiol. 2018 Feb;115:73-81

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory