Camk2d MGI Mouse Gene Detail - MGI:1341265 - calcium/calmodulin-dependent protein kinase II, delta

Symbol

Camk2d
Name

calcium/calmodulin-dependent protein kinase II, delta
Synonyms

2810011D23Rik, 8030469K03Rik, CaMK II, MGC:60852

Feature Type

protein coding gene
IDs

MGI:1341265
NCBI Gene: 108058
Alliance

genome feature page
Transcription Start Sites

19 TSS

Sequence Map

Chr3:126389951-126639975 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 55.97 cM
Mapping Data

2 experiments

SNPs within 2kb

7500 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341265	protein coding gene	Chr3:126389136-126639975 (+)
129S1/SvImJ	ENSMUSG00200003546	protein coding gene	Chr3:123109122-123358988 (+)
A/J	ENSMUSG00195007816	protein coding gene	Chr3:123246034-123495966 (+)
AKR/J	ENSMUSG00220021240	protein coding gene	Chr3:121700238-121950412 (+)
BALB/cJ	ENSMUSG00180003285	protein coding gene	Chr3:123176422-123426352 (+)
C3H/HeJ	ENSMUSG00175012278	protein coding gene	Chr3:122722977-122972898 (+)
C57BL/6NJ	ENSMUSG00215013482	protein coding gene	Chr3:123535009-123785188 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025611	protein coding gene	Chr3:119880835-120147415 (+)
CAST/EiJ	ENSTCUG00005003607	protein coding gene	Chr3:123787325-124045639 (+)
CBA/J	ENSMUSG00210003419	protein coding gene	Chr3:123353385-123603278 (+)
DBA/2J	ENSMUSG00185026027	protein coding gene	Chr3:123978523-124228826 (+)
FVB/NJ	ENSMUSG00205007290	protein coding gene	Chr3:122332933-122583111 (+)
JF1/MsJ	ENSUMUG00000019379	protein coding gene	Chr3:122721202-122971628 (+)
LP/J	ENSMUSG00230002783	protein coding gene	Chr3:125944200-126194077 (+)
NOD/ShiLtJ	ENSMUSG00190001258	protein coding gene	Chr3:124380924-124631086 (+)
NZO/HlLtJ	ENSMUSG00225001828	protein coding gene	Chr3:128422654-128672797 (+)
PWK/PhJ	ENSLUMG00010014606	protein coding gene	Chr3:122767021-123019169 (+)
SPRET/EiJ	ENSMSPG00010011899	protein coding gene	Chr3:123641551-123910608 (+)
WSB/EiJ	ENSIUOG00005016052	protein coding gene	Chr3:123531159-123789870 (+)

Human Ortholog

CAMK2D, calcium/calmodulin dependent protein kinase II delta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAMK2D, calcium/calmodulin dependent protein kinase II delta
Synonyms

CAMKD
Links

HGNC:1462

NCBI Gene ID: 817

UniProt: Q13557
Chr Location

4q26; chr4:113418054-113761927 (-) GRCh38

MGI Vertebrate Homology

Camk2d stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CAMK2D
Gene Tree

Camk2d

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References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 5 alleles in 5 genetic backgrounds
4 images
59 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

11
Gene trapped

1
Radiation induced

1
Targeted

10
Transgenic

2
Genomic Mutations

2 involving Camk2d
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced response to heart induced stress. Mice homozygous for an allele that produces an oxidant-resistant product exhibit reduced response to myocardial infarction in a diabetic model.

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All GO Annotations

99
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

82
cDNA Data

24
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAMK2D

Xenbase camk2d

ZFIN camk2d1, camk2d2

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All Sequences

195
RefSeq

90
UniProt

15
CCDS

CCDS17823.1, CCDS38624.1, CCDS51065.1, CCDS80015.1, CCDS80016.1, CCDS80017.1, CCDS84670.1, CCDS84671.1

Ensembl

ENSMUSG00000053819 (Evidence)
NCBI Gene

108058

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053819	Ensembl Gene Model \| MGI Sequence Detail	250025	C57BL/6J	± kb
transcript	ENSMUST00000200171	Ensembl \| MGI Sequence Detail	5396	Not Applicable
polypeptide	ENSMUSP00000143677	Ensembl \| MGI Sequence Detail	533	Not Applicable

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UniProt

15 Sequences
Protein Ontology

PR:000003201 calcium/calmodulin-dependent protein kinase type II subunit delta

(term hierarchy)
PDB

6BAB
EC

2.7.11.1, 2.7.11.17
InterPro Domains

IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain

IPR032710 NTF2-like domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q6PHZ2 4 sites, 1 O-linked glycan (3 sites)

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All nucleic 32

cDNA 28

Primer pair 4

Antibodies 2

Microarray probesets 6

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MGI:1923610, MGI:1924420

Summaries

All 153

Developmental Gene Expression 17

Diseases 1

Gene Ontology 21

Phenotypes 59
Earliest

J:73501 Bauch A, et al., Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta. Eur J Immunol. 1998 Jul;28(7):2167-77
Latest

J:377947 Di Bartolomei G, et al., Dilated cardiomyopathy-associated RNA-binding motif protein 20 regulates long pre-mRNAs in neurons. Elife. 2026 Jan 12;14

TSS for Camk2d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31566	Chr3:126389975-126389992 (+)	33 bp
Tssr31567	Chr3:126390001-126390021 (+)	60 bp
Tssr31568	Chr3:126390057-126390068 (+)	112 bp
Tssr31569	Chr3:126390462-126390503 (+)	532 bp
Tssr31570	Chr3:126390610-126390635 (+)	672 bp
Tssr31571	Chr3:126390642-126390687 (+)	714 bp
Tssr31572	Chr3:126390751-126390762 (+)	806 bp
Tssr31573	Chr3:126390887-126390903 (+)	944 bp
Tssr31574	Chr3:126390948-126391062 (+)	1,054 bp
Tssr31575	Chr3:126391064-126391084 (+)	1,123 bp
Tssr31576	Chr3:126400756-126400770 (+)	10,812 bp
Tssr31577	Chr3:126447178-126447181 (+)	57,229 bp
Tssr31579	Chr3:126574011-126574039 (+)	184,074 bp
Tssr31580	Chr3:126574046-126574056 (+)	184,100 bp
Tssr31581	Chr3:126574057-126574065 (+)	184,110 bp
Tssr31582	Chr3:126596962-126596965 (+)	207,013 bp
Tssr31583	Chr3:126604261-126604293 (+)	214,326 bp
Tssr31584	Chr3:126623683-126623689 (+)	233,735 bp
Tssr31585	Chr3:126638322-126638326 (+)	248,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29