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Tpbg Gene Detail
Summary
  • Symbol
    Tpbg
  • Name
    trophoblast glycoprotein
  • Synonyms
    5T4, 5T4 oncofetal antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341264
    NCBI Gene: 21983
  • Gene Overview
    MyGene.info: TPBG
Location & Maps
more
  • Sequence Map
    Chr9:85842380-85847040 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4661 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.40 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TPBG, trophoblast glycoprotein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPBG, trophoblast glycoprotein
    Orthology source: HomoloGene
  • Synonyms
    5T4, 5T4AG, M6P1, WAIF1
  • Links
    NCBI Gene ID: 7162
    neXtProt AC: NX_Q13641

  • Chr Location
    6q14-q15; chr6:82363206-82367417 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4859
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TPBG
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Tpbg
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit low penetrance hydrocephaly and premature death. Embryonic stem cells isolated from these mice exhibit impaired mesenchyme differentiation and reduced chemotaxis following differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045041 VEGA Gene Model | MGI Sequence Detail 4661 C57BL/6J ±  kb
transcript OTTMUST00000118356 VEGA | MGI Sequence Detail 3603 Not Applicable  
polypeptide OTTMUSP00000066070 VEGA | MGI Sequence Detail 426 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016569 trophoblast glycoprotein
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 2
Other
Accession IDs
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MGI:2143309
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:55628 King KW, et al., Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. Biochim Biophys Acta. 1999 Jun 9;1445(3):257-70
  • Latest
    J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory