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Tpbg
Gene Detail
Symbol

Name
ID
Tpbg
trophoblast glycoprotein
MGI:1341264
Synonyms
5T4, 5T4 oncofetal antigen
Feature Type
protein coding gene
Genetic Map
Chromosome 9
46.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:85842380-85847040 bp, + strand
From VEGA annotation of GRCm38

  4661 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TPBG
Gene Tree: Tpbg

Human
homologs
TPBG, trophoblast glycoprotein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7162
neXtProt AC: NX_Q13641

Human Synonyms: 5T4, 5T4AG, M6P1, WAIF1

Human Chr (Location): 6q14-q15; chr6:82363206-82367417 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit low penetrance hydrocephaly and premature death. Embryonic stem cells isolated from these mice exhibit impaired mesenchyme differentiation and reduced chemotaxis following differentiation.
 
Interactions
Tpbg interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process positive regulation of synapse assembly
Component cell surface, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (162)    Tissues (74)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 67
RNA in situ 95
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tpbg ; ZFIN tpbgb, tpbgl    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000045041 (Evidence)
Ensembl Gene Model ENSMUSG00000035274 (Evidence)
Entrez Gene 21983 (Evidence)
DFCI TC1582703, TC1591161, TC1600798
DoTS DT.101247277, DT.40178785
NIA Mouse Gene Index U010821
Consensus CDS Project CCDS23380.1
International Mouse Phenotyping Consortium Status Tpbg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045041 VEGA Gene Model | MGI Sequence Detail 4661 C57BL/6J ±  kb
transcript OTTMUST00000118356 VEGA | MGI Sequence Detail 3603 Not Applicable 
polypeptide OTTMUSP00000066070 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000016569 trophoblast glycoprotein
References
(Earliest) J:55628 King KW, et al., Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues. Biochim Biophys Acta. 1999 Jun 9;1445(3):257-70
(Latest) J:211830 Um JW, et al., Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep. 2014 Mar 27;6(6):1096-109
All references(37)
Other
accession IDs
MGI:2143309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory