About   Help   FAQ
Uba3
Gene Detail
Symbol

Name
ID
Uba3
ubiquitin-like modifier activating enzyme 3
MGI:1341217
Synonyms
A830034N06Rik, Ube1c, ubiquitin activating enzyme 3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
44.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:97183670-97205642 bp, - strand
From Ensembl annotation of GRCm38

  21973 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UBA3
Protein SuperFamily: NEDD8-activating enzyme E1 catalytic subunit
Gene Tree: Uba3

Human
homologs
UBA3, ubiquitin-like modifier activating enzyme 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9039
neXtProt AC: NX_Q8TBC4

Human Synonyms: hUBA3, NAE2, UBE1C

Human Chr (Location): 3p14.1; chr3:69054730-69080373 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(31) Spontaneous(1) Targeted(3) Transgenic(1)
Genomic Mutations involving Uba3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle.
 
Interactions
Uba3 interacts with 198 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process cell cycle, endomitotic cell cycle, ...
Component cytosol, nucleus
Function acid-amino acid ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 4
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA UBA3 ; Xenbase uba3 ; ZFIN uba3    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030061 (Evidence)
Entrez Gene 22200 (Evidence)
DFCI TC1572654, TC1616577, TC1642041, TC1682275
DoTS DT.101130803, DT.101356042, DT.101737718, DT.533373, DT.94262516, DT.94359573, DT.94359579
NIA Mouse Gene Index U027674
EC 6.3.2.-
Consensus CDS Project CCDS51859.1, CCDS51860.1
International Mouse Phenotyping Consortium Status Uba3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030061 Ensembl Gene Model | MGI Sequence Detail 21973 C57BL/6J ±  kb
transcript ENSMUST00000089287 Ensembl | MGI Sequence Detail 2443 Not Applicable 
polypeptide ENSMUSP00000086701 Ensembl | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014929 E2 binding
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 THIF-type NAD/FAD binding fold
InterPro IPR023318 Ubiquitin activating enzyme, alpha domain
InterPro IPR019572 Ubiquitin-activating enzyme, catalytic cysteine domain
InterPro IPR018074 Ubiquitin-activating enzyme, E1, active site
Protein Ontology PR:000016952 NEDD8-activating enzyme E1 catalytic subunit
References
(Earliest) J:54622 Gong L, et al., Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:1353580, MGI:2141496, MGI:2141693, MGI:2441832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory