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Uba3
Gene Detail
Symbol

Name
ID
Uba3
ubiquitin-like modifier activating enzyme 3
MGI:1341217
Synonyms
A830034N06Rik, Ube1c, ubiquitin activating enzyme 3
Feature Type
protein coding gene
Genetic Map
Chromosome 6
44.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:97183816-97205646 bp, - strand
From NCBI annotation of GRCm38

  21831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NEDD8-activating enzyme E1 catalytic subunit
Gene Tree: Uba3

Human
homologs
Human Homolog UBA3, ubiquitin-like modifier activating enzyme 3
NCBI Gene ID 9039
neXtProt AC  NX_Q8TBC4
Human Synonyms  hUBA3, NAE2, UBE1C
Human Chr (Location)  3p14.1; chr3:69054730-69080373 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(31) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle.
 
Interactions
Uba3 interacts with 198 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cellular protein modification process, ...
Component cytosol, nucleus
Function acid-amino acid ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 4
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030061 (Evidence)
Entrez Gene22200 (Evidence)
DFCITC1572654, TC1616577, TC1642041, TC1682275
DoTSDT.101130803, DT.101356042, DT.101737718, DT.94262516, DT.94359579, DT.533373, DT.94359573
NIA Mouse Gene IndexU027674
EC6.3.2.-
Consensus CDS ProjectCCDS51859.1, CCDS51860.1
International Mouse Knockout Project StatusUba3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22200 NCBI Gene Model | MGI Sequence Detail 21831 C57BL/6J ±  kb
transcript NM_001301857 RefSeq | MGI Sequence Detail 2835 C57BL/6 
polypeptide Q8C878 UniProt | EBI | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014929 E2 binding
InterPro IPR009036 Molybdenum cofactor biosynthesis, MoeB
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000594 UBA/THIF-type NAD/FAD binding fold
InterPro IPR019572 Ubiquitin-activating enzyme
InterPro IPR023318 Ubiquitin activating enzyme, alpha domain
InterPro IPR018074 Ubiquitin-activating enzyme, E1, active site
InterPro IPR000127 Ubiquitin-activating enzyme repeat
Protein Ontology PR:000016952 NEDD8-activating enzyme E1 catalytic subunit
Graphical View of Protein Domain Structure
References
(Earliest) J:54622 Gong L, et al., Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:1353580, MGI:2141496, MGI:2141693, MGI:2441832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory