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Uba3 Gene Detail
Summary
  • Symbol
    Uba3
  • Name
    ubiquitin-like modifier activating enzyme 3
  • Synonyms
    A830034N06Rik, Ube1c, ubiquitin activating enzyme 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341217
    NCBI Gene: 22200
  • Gene Overview
    MyGene.info: UBA3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:97183670-97205647 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21978 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 44.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBA3, ubiquitin like modifier activating enzyme 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hUBA3, NAE2, UBE1C
  • Links
    NCBI Gene ID: 9039
    neXtProt AC: NX_Q8TBC4
    UniProt: Q8TBC4

  • Chr Location
    3p14.1; chr3:69054730-69080373 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057821 VEGA Gene Model | MGI Sequence Detail 21978 C57BL/6J ±  kb
    transcript OTTMUST00000141976 VEGA | MGI Sequence Detail 2257 Not Applicable  
    polypeptide OTTMUSP00000074124 VEGA | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1353580, MGI:2141496, MGI:2141693, MGI:2441832
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:54622 Gong L, et al., Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem. 1999 Apr 23;274(17):12036-42
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory