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Lect1
Gene Detail
Symbol

Name
ID
Lect1
leukocyte cell derived chemotaxin 1
MGI:1341171
Synonyms
Bricd3, ChM-I, Chondromodulin 1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
42.74 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:79637690-79662170 bp, - strand
From VEGA annotation of GRCm38

  24481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LECT1
Gene Tree: Lect1

Human
homologs
LECT1, leukocyte cell derived chemotaxin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11061
neXtProt AC: NX_O75829

Human Synonyms: BRICD3, CHM1, CHM-I, MYETS1

Human Chr (Location): 13q14.3; chr13:52703264-52739812 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are viable and show no gross morphologic defects. While cartilage development and embryonic endochondral bone formation were found to be normal in mutant mice, one line of targeted mutants showed increased bone density and impaired bone resorption.
 
Interactions
Lect1 interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (235)    Tissues (71)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 208
Northern blot 18
RT-PCR 5
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LECT1 ; Xenbase lect1 ; ZFIN lect1    NEW 
Molecular
reagents
All nucleic(27) cDNA(26) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035201 (Evidence)
Ensembl Gene Model ENSMUSG00000022025 (Evidence)
Entrez Gene 16840 (Evidence)
UniGene 46561
DFCI TC1582733
DoTS DT.50316089
NIA Mouse Gene Index U035811
Consensus CDS Project CCDS27302.1
International Mouse Phenotyping Consortium Status Lect1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035201 VEGA Gene Model | MGI Sequence Detail 24481 C57BL/6J ±  kb
transcript OTTMUST00000089653 VEGA | MGI Sequence Detail 1362 Not Applicable 
polypeptide OTTMUSP00000049015 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(126)
Protein-related
information
ResourceIDDescription
InterPro IPR007084 BRICHOS domain
Protein Ontology PR:000009749 chondromodulin-1
References
(Earliest) J:34095 Spencer JA, et al., Expression of the serum response factor gene is regulated by serum response factor binding sites. J Biol Chem. 1996 Jul 12;271(28):16535-43
(Latest) J:198574 Sugimoto Y, et al., Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Development. 2013 Jun;140(11):2280-8
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory