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Lect1
Gene Detail
 Symbol
Name
ID
Lect1
leukocyte cell derived chemotaxin 1
MGI:1341171
Synonyms Bricd3, ChM-I, Chondromodulin 1
Feature Type protein coding gene
Genetic Map
Chromosome 14
42.74 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:79637690-79662170 bp, - strand
From VEGA annotation of GRCm38

  24481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lect1

Human
homologs
Human Homolog LECT1, leukocyte cell derived chemotaxin 1
NCBI Gene ID 11061
neXtProt AC  NX_O75829
Human Synonyms  BRICD3, CHM1, CHM-I, MYETS1
Human Chr (Location)  13q14.3; chr13:52703087-52739812 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are viable and show no gross morphologic defects. While cartilage development and embryonic endochondral bone formation were found to be normal in mutant mice, one line of targeted mutants showed increased bone density and impaired bone resorption.
 
Interactions
Lect1 interacts with 44 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cartilage development, cell differentiation, ...
Component extracellular region, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (228)    Tissues (68)    Images (36)
Theiler Stages: 19, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 208
Northern blot 18
cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(26)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035201 (Evidence)
Ensembl Gene ModelENSMUSG00000022025 (Evidence)
Entrez Gene16840 (Evidence)
UniGene46561
DFCITC1582733
DoTSDT.50316089
NIA Mouse Gene IndexU035811
Consensus CDS ProjectCCDS27302.1
International Mouse Knockout Project StatusLect1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035201 VEGA Gene Model | MGI Sequence Detail 24481 C57BL/6J ±  kb
transcript OTTMUST00000089653 VEGA | MGI Sequence Detail 1362 Not Applicable 
polypeptide OTTMUSP00000049015 VEGA | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)    SNPs within 2kb including multiple locations(126)
Protein-related
information
ResourceIDDescription
InterPro IPR007084 BRICHOS domain
Protein Ontology PR:000009749 chondromodulin-1
References (Earliest) J:34095 Spencer JA, et al., Expression of the serum response factor gene is regulated by serum response factor binding sites. J Biol Chem. 1996 Jul 12;271(28):16535-43
(Latest) J:198574 Sugimoto Y, et al., Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Development. 2013 Jun;140(11):2280-8
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory