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Lect1 Gene Detail
Summary
  • Symbol
    Lect1
  • Name
    leukocyte cell derived chemotaxin 1
  • Synonyms
    Bricd3, ChM-I, Chondromodulin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341171
    NCBI Gene: 16840
  • Gene Overview
    MyGene.info: LECT1
Location & Maps
more
  • Sequence Map
    Chr14:79637690-79662170 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 42.74 cM, cytoband D3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LECT1, leukocyte cell derived chemotaxin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LECT1, leukocyte cell derived chemotaxin 1
    Orthology source: HomoloGene
  • Synonyms
    BRICD3, CHM1, CHM-I, MYETS1
  • Links
    NCBI Gene ID: 11061
    neXtProt AC: NX_O75829

  • Chr Location
    13q14.3; chr13:52703264-52739812 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5095
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LECT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Lect1
  • Incidental Mutations
Homozygous mutant mice are viable and show no gross morphologic defects. While cartilage development and embryonic endochondral bone formation were found to be normal in mutant mice, one line of targeted mutants showed increased bone density and impairedbone resorption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035201 VEGA Gene Model | MGI Sequence Detail 24481 C57BL/6J ±  kb
transcript OTTMUST00000089653 VEGA | MGI Sequence Detail 1362 Not Applicable  
polypeptide OTTMUSP00000049015 VEGA | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    119 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009749 chondromodulin-1
  • InterPro Domains
    IPR007084 BRICHOS domain
Molecular
Reagents
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  • All nucleic 27
    cDNA 26
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 22
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:34095 Spencer JA, et al., Expression of the serum response factor gene is regulated by serum response factor binding sites. J Biol Chem. 1996 Jul 12;271(28):16535-43
  • Latest
    J:225092 Duverger O, et al., In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol. 2013 Mar;228(3):654-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory