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Spic
Gene Detail
 Symbol
Name
ID
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
MGI:1341168
Synonyms C76795, Prf, Spi-C
Feature Type protein coding gene
Genetic Map
Chromosome 10
44.14 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:88674772-88685015 bp, - strand
From VEGA annotation of GRCm38

  10244 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Spic

Human
homologs
Human Homolog SPIC, Spi-C transcription factor (Spi-1/PU.1 related)
NCBI Gene ID 121599
neXtProt AC  NX_Q8N5J4
Human Synonyms  SPI-C
Human Chr (Location)  12q23.2; chr12:101474535-101487176 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygote null mice have prenatal lethality with incomplete penetrance, absent red pulp macrophages, decreased phagocytosis of senescent red blood cell, and enlargement of spleens with age due to an increase in splenic iron levels.
 
Interactions
Spic interacts with 136 markers (Mir1a-1, Mir1a-2, Mir16-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process blastocyst development, cell differentiation, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (156)    Tissues (136)    Images (27)
Theiler Stages: 2, 3, 4, 5, 16, 17, 21, 22, 23, 27, 28
Assay TypeResults
RNA in situ 147
RT-PCR 9
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(26) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031753 (Evidence)
Ensembl Gene ModelENSMUSG00000004359 (Evidence)
Entrez Gene20728 (Evidence)
UniGene21642
DFCITC1584610, TC1630760
DoTSDT.101366597, DT.110613932, DT.489551, DT.91348543
NIA Mouse Gene IndexU032106
Consensus CDS ProjectCCDS36023.1
International Mouse Knockout Project StatusSpic
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031753 VEGA Gene Model | MGI Sequence Detail 10244 C57BL/6J ±  kb
transcript OTTMUST00000078661 VEGA | MGI Sequence Detail 1763 Not Applicable 
polypeptide OTTMUSP00000041860 VEGA | MGI Sequence Detail 242 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(131 from dbSNP Build 137)    SNPs within 2kb including multiple locations(135)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015526 transcription factor Spi-C
References (Earliest) J:54307 Bemark M, et al., Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development. J Biol Chem. 1999 Apr 9;274(15):10259-67
(Latest) J:210804 Haldar M, et al., Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34
All references(44)
Other
accession IDs
MGI:2143732, MGI:2143912

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory