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Spic Gene Detail
Summary
  • Symbol
    Spic
  • Name
    Spi-C transcription factor (Spi-1/PU.1 related)
  • Synonyms
    C76795, Prf, Spi-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341168
    NCBI Gene: 20728
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:88511131-88518885 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 44.14 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341168
 protein coding gene Chr10:88510634-88520877 (-)
129S1/SvImJ ENSMUSG00200027057
 protein coding gene Chr10:85008611-85018858 (-)
A/J ENSMUSG00195020210
 protein coding gene Chr10:85453439-85463857 (-)
AKR/J ENSMUSG00220020188
 protein coding gene Chr10:85059934-85070355 (-)
BALB/cJ ENSMUSG00180031969
 protein coding gene Chr10:85456439-85466855 (-)
C3H/HeJ ENSMUSG00175021494
 protein coding gene Chr10:85343291-85353496 (-)
C57BL/6NJ ENSMUSG00215024998
 protein coding gene Chr10:85011228-85021471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015711
 protein coding gene Chr10:82498470-82507768 (-)
CAST/EiJ ENSTCUG00005029755
 protein coding gene Chr10:84732391-84742767 (-)
CBA/J ENSMUSG00210032090
 protein coding gene Chr10:85183740-85193944 (-)
DBA/2J ENSMUSG00185038727
 protein coding gene Chr10:85413338-85423758 (-)
FVB/NJ ENSMUSG00205017204
 protein coding gene Chr10:85034835-85045252 (-)
JF1/MsJ ENSUMUG00000022117
 protein coding gene Chr10:86751436-86761796 (-)
LP/J ENSMUSG00230013360
 protein coding gene Chr10:87299510-87309928 (-)
NOD/ShiLtJ ENSMUSG00190017011
 protein coding gene Chr10:85438651-85449068 (-)
NZO/HlLtJ ENSMUSG00225051331
 protein coding gene Chr10:91561973-91572387 (-)
PWK/PhJ ENSLUMG00010022718
 protein coding gene Chr10:85040296-85050636 (-)
SPRET/EiJ ENSMSPG00010029801
 protein coding gene Chr10:86557299-86568192 (-)
WSB/EiJ ENSIUOG00005036073
 protein coding gene Chr10:85138239-85148430 (-)



Homology
more
  • Human Ortholog
    SPIC, Spi-C transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPIC, Spi-C transcription factor
  • Synonyms
    SPI-C
  • Links
    NCBI Gene ID: 121599
    UniProt: Q8N5J4

  • Chr Location
    12q23.2; chr12:101475336-101486997 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have prenatal lethality with incomplete penetrance, absent red pulp macrophages, decreased phagocytosis of senescent red blood cell, and enlargement of spleens with age due to an increase in splenic iron levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    147
  • cDNA Data
    28
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20728 NCBI Gene Model | MGI Sequence Detail 7755 C57BL/6J ±  kb
    transcript NM_011461 RefSeq | MGI Sequence Detail 1266 C57BL/6  
    polypeptide Q6P3D7 UniProt | EBI | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 28
      Primer pair 4
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143732, MGI:2143912
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 17
      Gene Ontology 5
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:386399 Asplund H, et al., Splenic erythrophagocytosis is regulated by ALX/FPR2 signaling. Haematologica. 2026 May 1;111(5):1759-1773
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory