About   Help   FAQ
Spic Gene Detail
Summary
  • Symbol
    Spic
  • Name
    Spi-C transcription factor (Spi-1/PU.1 related)
  • Synonyms
    C76795, Prf, Spi-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341168
    NCBI Gene: 20728
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:88674772-88685015 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10244 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 44.14 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPIC, Spi-C transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPIC, Spi-C transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPI-C
  • Links
    NCBI Gene ID: 121599
    neXtProt AC: NX_Q8N5J4
    UniProt: Q8N5J4

  • Chr Location
    12q23.2; chr12:101475276-101486997 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7953
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPIC
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have prenatal lethality with incomplete penetrance, absent red pulp macrophages, decreased phagocytosis of senescent red blood cell, and enlargement of spleens with age due to an increase in splenic iron levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031753 VEGA Gene Model | MGI Sequence Detail 10244 C57BL/6J ±  kb
    transcript OTTMUST00000078661 VEGA | MGI Sequence Detail 1763 Not Applicable  
    polypeptide OTTMUSP00000041860 VEGA | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      127 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 26
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143732, MGI:2143912
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236722 Ulyanova T, et al., The macrophage contribution to stress erythropoiesis: when less is enough. Blood. 2016 Sep 29;128(13):1756-65

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory