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Spic Gene Detail
Summary
  • Symbol
    Spic
  • Name
    Spi-C transcription factor (Spi-1/PU.1 related)
  • Synonyms
    C76795, Prf, Spi-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341168
    NCBI Gene: 20728
Location & Maps
more
  • Sequence Map
    Chr10:88674772-88685015 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10244 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 44.14 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPIC, Spi-C transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPIC, Spi-C transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPI-C
  • Links
    NCBI Gene ID: 121599
    neXtProt AC: NX_Q8N5J4

  • Chr Location
    12q23.2; chr12:101475323-101487566 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7953
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SPIC
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Spic
  • Incidental Mutations
Homozygote null mice have prenatal lethality with incomplete penetrance, absent red pulp macrophages, decreased phagocytosis of senescent red blood cell, and enlargement of spleens with age due to an increase in splenic iron levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031753 VEGA Gene Model | MGI Sequence Detail 10244 C57BL/6J ±  kb
transcript OTTMUST00000078661 VEGA | MGI Sequence Detail 1763 Not Applicable  
polypeptide OTTMUSP00000041860 VEGA | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015526 transcription factor Spi-C
  • InterPro Domains
    IPR000418 Ets domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 30
    Genomic 1
    cDNA 26
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:2143732, MGI:2143912
References
more
  • Summaries
    All 43
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:54307 Bemark M, et al., Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development. J Biol Chem. 1999 Apr 9;274(15):10259-67
  • Latest
    J:232629 Bednarski JJ, et al., RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med. 2016 Feb 8;213(2):209-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory