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Tacc3
Gene Detail
 Symbol
Name
ID
Tacc3
transforming, acidic coiled-coil containing protein 3
MGI:1341163
Synonyms Aint, Arnt interacting protein
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:33658128-33678995 bp, + strand
From VEGA annotation of GRCm38

  20868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81618  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tacc3

Human
homologs
Human Homolog TACC3, transforming, acidic coiled-coil containing protein 3
NCBI Gene ID 10460
neXtProt AC  NX_Q9Y6A5
Human Synonyms  ERIC1, ERIC-1
Human Chr (Location)  4p16.3; chr4:1721490-1745178 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TACC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Chemically induced (ENU)(1) Gene trapped(16) Radiation induced(3) Targeted(4)
Genomic Mutations involving Tacc3 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations cause embryonic growth delay and prenatal death. Homozygotes for a null allele show hematopoietic deficiencies and severe facial clefts. Homozygotes for a hypomorphic allele die neonatally with malformed axial skeletons due to failed mitosis in mesenchymal sclerotome cells.
 
Alleles Annotated to Human Diseases(3)   
Interactions
Tacc3 interacts with 94 markers (Mir20a, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process astral microtubule organization, cell proliferation, ...
Component centrosome, cytoplasm
Function protein binding, protein domain specific binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (230)    Tissues (120)    Images (40)
Theiler Stages: 1, 2, 3, 4, 10, 14, 15, 17, 18, 19, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 206
Northern blot 16
RT-PCR 8
cDNA source data(143)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(145) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025055 (Evidence)
Ensembl Gene ModelENSMUSG00000037313 (Evidence)
Entrez Gene21335 (Evidence)
UniGene379024
DFCITC1572533, TC1594358, TC1595262, TC1679062, TC1694844
DoTSDT.101389785, DT.110698513, DT.110698548, DT.40186683, DT.91588213, DT.94283055, DT.94283075, DT.97337503
Consensus CDS ProjectCCDS39065.1
International Mouse Knockout Project StatusTacc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025055 VEGA Gene Model | MGI Sequence Detail 20868 C57BL/6J ±  kb
transcript OTTMUST00000061652 VEGA | MGI Sequence Detail 2669 Not Applicable 
polypeptide OTTMUSP00000030279 VEGA | MGI Sequence Detail 637 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(14) UniProt(9)
Polymorphisms SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007707 Transforming acidic coiled-coil
Protein Ontology PR:000016008 transforming acidic coiled-coil-containing protein 3
References (Earliest) J:55618 Still IH, et al., The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics. 1999 Jun 1;58(2):165-70
(Latest) J:190063 Yang YT, et al., DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci. 2012 Sep;15(9):1201-10
All references(46)
Other
accession IDs
MGI:2141334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory