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Tacc3 Gene Detail
Summary
  • Symbol
    Tacc3
  • Name
    transforming, acidic coiled-coil containing protein 3
  • Synonyms
    Aint, Arnt interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341163
    NCBI Gene: 21335
  • Gene Overview
    MyGene.info: TACC3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:33658128-33678995 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20868 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TACC3, transforming acidic coiled-coil containing protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TACC3, transforming acidic coiled-coil containing protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERIC1, ERIC-1
  • Links
    NCBI Gene ID: 10460
    neXtProt AC: NX_Q9Y6A5
    UniProt: Q9Y6A5

  • Chr Location
    4p16.3; chr4:1721383-1745178 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 81618
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TACC3
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations cause embryonic growth delay and prenatal death. Homozygotes for a null allele show hematopoietic deficiencies and severe facial clefts. Homozygotes for a hypomorphic allele die neonatally with malformed axial skeletons due to failed mitosis in mesenchymal sclerotome cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025055 VEGA Gene Model | MGI Sequence Detail 20868 C57BL/6J ±  kb
    transcript OTTMUST00000061652 VEGA | MGI Sequence Detail 2669 Not Applicable  
    polypeptide OTTMUSP00000030279 VEGA | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      98 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • PDB
    • InterPro Domains
      IPR007707 Transforming acidic coiled-coil-containing protein, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 147
      cDNA 144
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141334
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 10
      Phenotypes 27
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:190063 Yang YT, et al., DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci. 2012 Sep;15(9):1201-10

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory