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Tacc3 Gene Detail
Summary
  • Symbol
    Tacc3
  • Name
    transforming, acidic coiled-coil containing protein 3
  • Synonyms
    Aint, Arnt interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341163
    NCBI Gene: 21335
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33815472-33836339 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341163
 protein coding gene Chr5:33814808-33836339 (+)
129S1/SvImJ ENSMUSG00200012277
 protein coding gene Chr5:29287191-29298171 (+)
A/J ENSMUSG00195043389
 protein coding gene Chr5:28764883-28775866 (+)
AKR/J ENSMUSG00220007979
 protein coding gene Chr5:28785311-28796294 (+)
BALB/cJ ENSMUSG00180031447
 protein coding gene Chr5:28567833-28578817 (+)
C3H/HeJ ENSMUSG00175045152
 protein coding gene Chr5:30547442-30558429 (+)
C57BL/6NJ ENSMUSG00215039263
 protein coding gene Chr5:29284355-29295335 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027119
 protein coding gene Chr5:28611725-28633157 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210047189
 protein coding gene Chr5:29515133-29526116 (+)
DBA/2J ENSMUSG00185016174
 protein coding gene Chr5:31379505-31390504 (+)
FVB/NJ ENSMUSG00205016394
 protein coding gene Chr5:28270381-28281367 (+)
JF1/MsJ ENSUMUG00000038214
 protein coding gene Chr5:35987888-35998709 (+)
LP/J ENSMUSG00230042450
 protein coding gene Chr5:35990878-36001857 (+)
NOD/ShiLtJ ENSMUSG00190015332
 protein coding gene Chr5:28544331-28555314 (+)
NZO/HlLtJ ENSMUSG00225016975
 protein coding gene Chr5:41197101-41208080 (+)
PWK/PhJ ENSLUMG00010042602
 protein coding gene Chr5:28683005-28693893 (+)
SPRET/EiJ ENSMSPG00010038136
 protein coding gene Chr5:29855067-29870081 (+)
WSB/EiJ ENSIUOG00005016588
 protein coding gene Chr5:31474333-31485311 (+)



Homology
more
  • Human Ortholog
    TACC3, transforming acidic coiled-coil containing protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TACC3, transforming acidic coiled-coil containing protein 3
  • Synonyms
    ERIC-1, ERIC1, maskin, Tacc4
  • Links
    NCBI Gene ID: 10460
    UniProt: Q9Y6A5

  • Chr Location
    4p16.3; chr4:1712858-1745178 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations cause embryonic growth delay and prenatal death. Homozygotes for a null allele show hematopoietic deficiencies and severe facial clefts. Homozygotes for a hypomorphic allele die neonatally with malformed axial skeletons due to failed mitosis in mesenchymal sclerotome cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    137
  • cDNA Data
    144
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037313 Ensembl Gene Model | MGI Sequence Detail 20868 C57BL/6J ±  kb
    transcript ENSMUST00000074849 Ensembl | MGI Sequence Detail 2669 Not Applicable  
    polypeptide ENSMUSP00000074394 Ensembl | MGI Sequence Detail 637 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 146
      Primer pair 2
      Other 2
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141334
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 14
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory