Tacc3
Gene Detail

Symbol Name ID

Tacc3 transforming, acidic coiled-coil containing protein 3 MGI:1341163

Synonyms

Aint, Arnt interacting protein

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:33658128-33678995 bp, + strand From VEGA annotation of GRCm38   20868 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:81618  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tacc3

Human homologs

Human Homolog		TACC3, transforming, acidic coiled-coil containing protein 3
NCBI Gene ID		10460
neXtProt AC		NX_Q9Y6A5
Human Synonyms		ERIC1, ERIC-1
Human Chr (Location)		4p16.3; chr4:1723217-1746905 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TACC3

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Nullizygous mutations cause embryonic growth delay and prenatal death. Homozygotes for a null allele show hematopoietic deficiencies and severe facial clefts. Homozygotes for a hypomorphic allele die neonatally with malformed axial skeletons due to failed mitosis in mesenchymal sclerotome cells.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	astral microtubule organization, cell proliferation, ...
Component	centrosome, cytoplasm
Function	protein binding, protein domain specific binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (192)    Tissues (89)    Images (30)
Theiler Stages: 1, 2, 3, 5, 10, 15, 17, 18, 19, 21, 23, 25, 28

Assay Type	Results
RNA in situ	169
Northern blot	8
RT-PCR	15

cDNA source data(140)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(144) cDNA(142) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025055 (Evidence)
Ensembl Gene Model	ENSMUSG00000037313 (Evidence)
Entrez Gene	21335 (Evidence)
UniGene	379024
DFCI	TC1572533, TC1594358, TC1595262, TC1679062, TC1694844
DoTS	DT.101389785, DT.110698513, DT.110698548, DT.40186683, DT.91588213, DT.94283055, DT.94283075, DT.97337503
Consensus CDS Project	CCDS39065.1
International Mouse Knockout Project Status	Tacc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025055	VEGA Gene Model | MGI Sequence Detail	20868	C57BL/6J
transcript	OTTMUST00000061652	VEGA | MGI Sequence Detail	2669	Not Applicable
polypeptide	OTTMUSP00000030279	VEGA | MGI Sequence Detail	637	Not Applicable

All sequences(76) RefSeq(3) UniProt(9)

Polymorphisms

SNPs(71 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007707	Transforming acidic coiled-coil
Protein Ontology	PR:000016008	transforming acidic coiled-coil-containing protein 3

References

(Earliest) J:55618 Still IH, et al., The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics. 1999 Jun 1;58(2):165-70
(Latest) J:190063 Yang YT, et al., DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nat Neurosci. 2012 Sep;15(9):1201-10
All references(45)

Other accession IDs

MGI:2141334