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Fcnb
Gene Detail
 Symbol
Name
ID
Fcnb
ficolin B
MGI:1341158
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.38 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:28076378-28084885 bp, - strand
From VEGA annotation of GRCm38

  8508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Fcnb

Human
homologs
Human Homolog FCN1, ficolin (collagen/fibrinogen domain containing) 1
NCBI Gene ID 2219
neXtProt AC  NX_O00602
Human Synonyms  FCNM
Human Chr (Location)  9q34; chr9:134905865-134918003 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased susceptibility to Streptococcus pneumoniae infection.
 
Interactions
Fcnb interacts with 18 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process complement activation, lectin pathway, immune system process, ...
Component collagen trimer, extracellular region
Function carbohydrate derivative binding, sialic acid binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (51)    Tissues (20)    Images (20)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 22
Northern blot 6
RT-PCR 23
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000011624 (Evidence)
Ensembl Gene ModelENSMUSG00000026835 (Evidence)
Entrez Gene14134 (Evidence)
UniGene182935
DFCITC1587046
DoTSDT.101303651, DT.40169753, DT.91329407
NIA Mouse Gene IndexU022445
Consensus CDS ProjectCCDS15832.1
International Mouse Knockout Project StatusFcnb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011624 VEGA Gene Model | MGI Sequence Detail 8508 C57BL/6J ±  kb
transcript OTTMUST00000027191 VEGA | MGI Sequence Detail 1170 Not Applicable 
polypeptide OTTMUSP00000012370 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007438 ficolin-2
References (Earliest) J:48250 Iwama A, et al., Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res. 1998 Jun 15;26(12):3034-43
(Latest) J:202096 Weber-Steffens D, et al., Immature mouse granulocytic myeloid cells are characterized by production of ficolin-B. Mol Immunol. 2013 Dec;56(4):488-96
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory